Results 71 to 80 of about 7,513 (165)

GLP‐2 and GIP acutely increase superior mesenteric artery blood flow in male rats, and the effect is independent of nitric oxide and vasoactive intestinal peptide

Physiological Reports, Volume 13, Issue 23, December 2025.
GLP‐2 and GIP acutely increase superior mesenteric artery blood flow in male rats, and the effect is independent of nitric oxide and vasoactive intestinal peptide. Abstract Following a meal, splanchnic blood flow increases. This is important for nutrient absorption and is regulated by the enteric nervous system and gastrointestinal (GI) hormones ...
Katrine D. Galsgaard, Bolette Hartmann, Mette M. Rosenkilde, Jens J. Holst, Lærke S. Gasbjerg, Charlotte M. Sørensen   +5 more
wiley   +1 more source

Exercise protects against chronic β-adrenergic remodeling of the heart by activation of endothelial nitric oxide synthase. [PDF]

PLoS ONE, 2014
Extensive data have shown that exercise training can provide cardio-protection against pathological cardiac hypertrophy. However, how long the heart can retain cardio-protective phenotype after the cessation of exercise is currently unknown.
Liang Yang, Zhe Jia, Lei Yang, Mengmeng Zhu, Jincai Zhang, Jie Liu, Ping Wu, Wencong Tian, Jing Li, Zhi Qi, Xiangdong Tang   +10 more
doaj   +1 more source

Is Glyceryl Trinitrate, a Nitric Oxide Donor Responsible for Ameliorating the Chemical-Induced Tissue Injury In Vivo?

Molecules, 2022
Oxidative stress induced by well-known toxins including ferric nitrilotriacetate (Fe-NTA), carbon tetrachloride (CCl4) and thioacetamide (TAA) has been attributed to causing tissue injury in the liver and kidney.
Ayesha Rahman Ahmed, Mahiba Ahmed, Senty Vun-Sang, Mohammad Iqbal   +3 more
doaj   +1 more source

Alterations of myocardial ketone metabolism in heart failure with preserved ejection fraction (HFpEF)

ESC Heart Failure, Volume 12, Issue 4, Page 3179-3182, August 2025.
Abstract Introduction Cardiac energy metabolism is disrupted in heart failure with preserved ejection fraction (HFpEF), as characterized by a switch from glucose oxidation towards fatty acid oxidation. However, although oxidation of ketones is an important source of ATP it remains unclear how the heart oxidizes ketones in HFpEF.
Qiuyu Sun, Cory S. Wagg, Nathan Wong, Kaleigh Wei, Ezra B. Ketema, Liyan Zhang, Liye Fang, John M. Seubert, Gary D. Lopaschuk   +8 more
wiley   +1 more source

Naringenin inhibits pacemaking activity in interstitial cells of Cajal from murine small intestine

Integrative Medicine Research, 2017
Background: Naringenin (NRG) is a common dietary polyphenolic constituent of fruits. NRG has diverse pharmacological activities, and is used in traditional medicine to treat various diseases including gastrointestinal (GI) disorders.
Hyun Jung Kim, Byung Joo Kim
doaj   +1 more source

Aging‐Associated Liver Sinusoidal Endothelial Cells Dysfunction Aggravates the Progression of Metabolic Dysfunction‐Associated Steatotic Liver Disease

Aging Cell, Volume 24, Issue 5, May 2025.
Aged rats and human are more susceptible to MASLD‐related liver injury, steatosis, and fibrosis, accompanied by worsening of endothelial dysfunction. The SIRT1/p‐eNOS/NO pathway is involved in aggravated MASLD caused by aging‐related LSECs dysfunction.
Qingqing Dai, Quratul Ain, Navodita Seth, Hongchuan Zhao, Michael Rooney, Alexander Zipprich   +5 more
wiley   +1 more source

NR2B phosphorylation at tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia. [PDF]

, 2014
Background and purposeThe NR2B subunit of the N-methyl-d-aspartate (NMDA) receptor is phosphorylated by the Src family kinase Fyn in brain, with tyrosine (Y) 1472 as the major phosphorylation site. Although Y1472 phosphorylation is important for synaptic
Brennan-Minnella, Angela M, Ferriero, Donna M, Jiang, Xiangning, Knox, Renatta, Lu, Fuxin, Nakazawa, Takanobu, Swanson, Raymond A, Yamamoto, Tadashi, Yang, Diana   +8 more
core   +1 more source

Evaluation of the potential role of glutamatergic, cholinergic, and nitrergic systems in the dopamine release induced by the pesticide glyphosate in rat striatum

Journal of Applied Toxicology, Volume 44, Issue 10, Page 1489-1503, October 2024.
Abstract Glyphosate (GLY) is a pesticide that severely alters nigrostriatal dopaminergic neurotransmission, inducing great increases in dopamine release from rat dorsal striatum. This GLY‐induced striatal dopamine overflow occurs through mechanisms not yet fully understood, hence the interest in evaluating the role of other neurotransmitter systems in ...
Carmen Costas‐Ferreira, Rafael Durán, Lilian R. F. Faro   +2 more
wiley   +1 more source

Testosterone Antagonizes Doxorubicin‐Induced Senescence of Cardiomyocytes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundChronic cardiotoxicity is less common in male than in female patients receiving doxorubicin and other anthracyclines at puberty and adolescence.
Paola Altieri, Chiara Barisione, Edoardo Lazzarini, Anna Garuti, Gian Paolo Bezante, Marco Canepa, Paolo Spallarossa, Carlo Gabriele Tocchetti, Sveva Bollini, Claudio Brunelli, Pietro Ameri   +10 more
doaj   +1 more source

Pre-weaning growth hormone treatment reverses hypertension and endothelial dysfunction in adult male offspring of mothers undernourished during pregnancy. [PDF]

PLoS ONE, 2013
Maternal undernutrition results in elevated blood pressure (BP) and endothelial dysfunction in adult offspring. However, few studies have investigated interventions during early life to ameliorate the programming of hypertension and vascular disorders ...
Clint Gray, Minglan Li, Clare M Reynolds, Mark H Vickers   +3 more
doaj   +1 more source