Results 71 to 80 of about 1,078,448 (173)

Testosterone Antagonizes Doxorubicin‐Induced Senescence of Cardiomyocytes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundChronic cardiotoxicity is less common in male than in female patients receiving doxorubicin and other anthracyclines at puberty and adolescence.
Paola Altieri, Chiara Barisione, Edoardo Lazzarini, Anna Garuti, Gian Paolo Bezante, Marco Canepa, Paolo Spallarossa, Carlo Gabriele Tocchetti, Sveva Bollini, Claudio Brunelli, Pietro Ameri   +10 more
doaj   +1 more source

Role of L‐type Ca2+‐channels in the vasorelaxing response to finerenone in arteries of human visceral adipose tissue

Physiological Reports, Volume 12, Issue 18, September 2024.
The vasoactive response to the nonsteroidal mineralocorticoid receptor antagonist (MRA) finerenone was tested ex vivo in arteries of human visceral adipose tissue (VAT). Finerenone elicited endothelium‐independent vasorelaxation in arteries precontracted with different vasoconstrictors; the steroidal MRA potassium canrenoate, by contrast, did not relax
Francesca Schinzari, Alessandro De Stefano, Giuseppe Sica, Marco Mettimano, Carmine Cardillo, Manfredi Tesauro   +5 more
wiley   +1 more source

Pre-weaning growth hormone treatment reverses hypertension and endothelial dysfunction in adult male offspring of mothers undernourished during pregnancy. [PDF]

PLoS ONE, 2013
Maternal undernutrition results in elevated blood pressure (BP) and endothelial dysfunction in adult offspring. However, few studies have investigated interventions during early life to ameliorate the programming of hypertension and vascular disorders ...
Clint Gray, Minglan Li, Clare M Reynolds, Mark H Vickers   +3 more
doaj   +1 more source

Oliveria decumbens, a Long‐Neglected Plant with Promising Phytochemical and Biological Properties

Chemistry &Biodiversity, Volume 21, Issue 7, July 2024.
Abstract Oliveria decumbens is a folkloric medicinal plant belonging to the Apiaceae family, traditionally utilized to treat various diseases like gastrointestinal disorders, fever, and wounds. This review aims to provide a comprehensive overview of the plant‘s phytochemical composition and biological properties, with potential implications for various
Anahita Boveiri Dehsheikh, Mohammad Mahmoodi Sourestani, Naeimeh Enayatizamir, Mehdi Safdarian, Javad Mottaghipisheh   +4 more
wiley   +1 more source

N^ω-Nitroarginine-Containing Dipeptide Amides. Potent and Highly Selective Inhibitors of Neuronal Nitric Oxide Synthase

, 2016
Selective inhibition of the isoforms of nitric oxide synthase (NOS) could be therapeutically useful in the treatment of certain disease states arising from the overproduction of nitric oxide (NO). Recently, we reported the dipeptide methyl ester, d-Phe-d-
Pavel Martasek (631903), Linda J. Roman (462928), Richard B. Silverman (685069), Bettie Sue Siler Masters (3008688), Hui Huang (4122)   +4 more
core   +1 more source

Role of an indole-thiazolidine molecule PPAR pan-agonist and COX inhibitor on inflammation and microcirculatory damage in acute gastric lesions. [PDF]

PLoS ONE, 2013
The present study aimed to show the in vivo mechanisms of action of an indole-thiazolidine molecule peroxisome-proliferator activated receptor pan-agonist (PPAR pan) and cyclooxygenase (COX) inhibitor, LYSO-7, in an ethanol/HCl-induced (Et/HCl) gastric ...
José Roberto Santin, Isabel Daufenback Machado, Stephen F P Rodrigues, Simone Teixeira, Marcelo N Muscará, Suely Lins Galdino, Ivan da Rocha Pitta, Sandra H P Farsky   +7 more
doaj   +1 more source

Thrombospondin‐1 Regulates Trophoblast Necroptosis via NEDD4‐Mediated Ubiquitination of TAK1 in Preeclampsia

Advanced Science, Volume 11, Issue 21, June 5, 2024.
The down‐regulation of THBS1 can destabilize TAK1 via NEDD4‐mediated, K48‐linked TAK1 ubiquitination, resulting in the activation of the necroptosis and DAMPs release in trophoblast cells, thus participating in the pathogenesis of PE. Abstract Preeclampsia (PE) is considered as a disease of placental origin. However, the specific mechanism of placental
Haoyue Hu, Jing Ma, You Peng, Rixuan Feng, Chenling Luo, Minyi Zhang, Zixin Tao, Lu Chen, Tao Zhang, Wenqian Chen, Qian Yin, Jinguo Zhai, Jun Chen, Ailan Yin, Chi Chiu Wang, Mei Zhong   +15 more
wiley   +1 more source

Protective effect of picroside II on myocardial ischemia reperfusion injury in rats

Drug Design, Development and Therapy, 2014
Nan Wu, Wenna Li, Wenqi Shu, Dalin Jia Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China Abstract: The aim of this study was to determine the effect of picroside II on ...
Wu N, Li W, Shu W, Jia D
doaj  

Incorporating Thiobarbituric Acid with 1,2,4-Triazin-6-one Containing Nitroarginine Moiety [PDF]

, 2014
: Nitrilimines (2a,b), react with nitroarginine methyl ester (3) at room temperature, through cyclocondensation reaction, to give 1-aryl-3-substituted-1,2,4-triazin-6-ones (4a,b).
Abdel-Rahman, Reda M., El-Abadla, Naser S., EL- Nwairy, Khaled A., Abu Thaher, Bassam A.   +3 more
core  

NG-monomethyl-L-arginine and nitroarginine potentiate pressor responsiveness of vasoconstrictors in conscious rats

, 1992
NG-monomethyl-L-arginine (NMA) and nitroarginine have been reported to be competitive inhibitors of the production of endothelium-derived relaxing factor (EDRF).
S. L. Whittemore, K. P. Conrad
core   +1 more source