Results 81 to 90 of about 1,078,448 (173)

Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS. [PDF]

PLoS ONE, 2012
The hormone, relaxin, inhibits aberrant myofibroblast differentiation and collagen deposition by disrupting the TGF-β1/Smad2 axis, via its cognate receptor, Relaxin Family Peptide Receptor 1 (RXFP1), extracellular signal-regulated kinase (ERK)1/2 ...
Bryna Suet Man Chow, Elaine Guo Yan Chew, Chongxin Zhao, Ross A D Bathgate, Tim D Hewitson, Chrishan S Samuel   +5 more
doaj   +1 more source

Ginsenoside Re inhibits pacemaker potentials via adenosine triphosphate-sensitive potassium channels and the cyclic guanosine monophosphate/nitric oxide-dependent pathway in cultured interstitial cells of Cajal from mouse small intestine

Journal of Ginseng Research, 2015
Background: Ginseng belongs to the genus Panax. Its main active ingredients are the ginsenosides. Interstitial cells of Cajal (ICCs) are the pacemaker cells of the gastrointestinal (GI) tract.
Noo Ri Hong, Hyun Soo Park, Tae Seok Ahn, Hyun Jung Kim, Ki-Tae Ha, Byung Joo Kim   +5 more
doaj   +1 more source

Selective Inhibition of Neuronal Nitric Oxide Synthase by N^ω-Nitroarginine- and Phenylalanine-Containing Dipeptides and Dipeptide Esters

, 2016
A series of Nω-nitroarginine (ArgNO2)- and phenylalanine-containing dipeptides and dipeptide esters were synthesized as potential selective inhibitors of neuronal nitric oxide synthase (nNOS).
Pavel Martasek (631903), Michael A. Marletta (1858000), Richard B. Silverman (685069), Hui Huang (4122)   +3 more
core   +1 more source

Divergent cardiac and renal effects of miR-181c-5p inhibition in a rodent heart failure model

Frontiers in Cardiovascular Medicine
AimsMiR-181c-5p overexpression associates with heart failure (HF) and cardiac damage, but the underlying pathophysiology remains unclear. This study investigated the effect of miR-181c-5p inhibition on cardiac function and fibrosis in a rodent model of ...
Jente R. A. Boen, Jente R. A. Boen, Andreas B. Gevaert, Andreas B. Gevaert, Amélie Dendooven, Amélie Dendooven, Dustin Krüger, Michiel Tubeeckx, Jens Van Fraeyenhove, Tine Bruyns, Vincent F. M. Segers, Vincent F. M. Segers, Emeline M. Van Craenenbroeck, Emeline M. Van Craenenbroeck   +13 more
doaj   +1 more source

An investigation into the conversion of specific carbon atoms in oleic acid and methyl oleate to particulate matter in a diesel engine and tube reactor [PDF]

, 2015
The paper is concerned with particulate formation from the fuels oleic acid and methyl oleate. In particular the paper reports, quantitatively, the propensity of individual carbon atoms in these two molecules in being converted to particulate.
Ladommatos, N, Hellier, Paul, Jourdan, Anne-Lise, Eveleigh, A, Hellier, P, Jourdan, A-L, Eveleigh, Aaron, Ladommatos, Nicos   +7 more
core   +1 more source

Effect of L-Arginine and L-NAME treatments on polymorphonuclear leukocytes and mononuclear cells influx during tumor growth Efeito dos tratamentos com L-Arginina e L-NAME sobre o influxo de leucócitos polimorfonucleares e células mononucleares durante o desenvolvimento tumoral

Acta Cirúrgica Brasileira, 2009
PURPOSE: Evaluate polymorphonuclear leukocytes (PMN's) and mononuclear cells (MN's) involvement in the Ehrlich´s solid tumor (ET) growth. METHODS: 90 Swiss mice were inoculated with 10(7) tumor cells (sc), distributed in three groups and treated once a ...
Olívia Teixeira Gomes Reis, Juliana Crepaldi Raini, Silvana Torossian Coradi, Dulce Helena Jardim Constantino   +3 more
doaj   +1 more source

Optimization of the epoxidation of methyl ester of palm fatty acid distillate [PDF]

, 2009
Methyl ester of palm fatty acid distillate (PFAD-ME) can be used for producing epoxide compounds. PFADME consists of 39.3% of oleic acid (C18:1) and has an iodine value of 49.2 g I2/100 g. It can be converted to a low oxirane content epoxide which can be
Yeong, Shoot Kian, Abdullah, Dzulkefly Kuang, Lim, Wen Huei, Lee, P. L., Wan Yunus, Wan Md. Zin   +4 more
core   +1 more source

Identification of ageing-associated gene signatures in heart failure with preserved ejection fraction by integrated bioinformatics analysis and machine learning

Genes and Diseases
The incidence of heart failure with preserved ejection fraction (HFpEF) increases with the ageing of populations. This study aimed to explore ageing-associated gene signatures in HFpEF to develop new diagnostic biomarkers and provide new insights into ...
Guoxing Li, Qingju Zhou, Ming Xie, Boying Zhao, Keyu Zhang, Yuan Luo, Lingwen Kong, Diansa Gao, Yongzheng Guo   +8 more
doaj   +1 more source

The Effects of L-Arginine (the Precursor of Nitric Oxide) and L-NAME (Nitric Oxide Synthase Inhibitor) on Coronary Angiogenesis in Normal Rats

مجله دانشکده پزشکی اصفهان, 2012
Background: Nitric oxide (NO) has beneficial effects on cardiovascular system including improvement of angiogenesis. The aim of this study was to evaluate the effects of L-arginine (the precursor of NO) and L-NG-nitroarginine methyl ester (L-NAME) (NO ...
Majid Khazaei, Mohammad Amin Moshayedi, Massoud Teimouri, Shahrzad Aghili, Saeed Montazeri, Roshanak Mehdipour, Fazolah Hashemzehi, Hourossadat Hashemi Jazi   +7 more
doaj  

Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model

Kaohsiung Journal of Medical Sciences, 2014
This study investigates whether endothelin-1 (ET-1) mediates monocrotaline (MCT)-induced pulmonary artery hypertension (PAH) and right ventricular hypertrophy (RVH), and if so, whether the G-protein coupled receptor antagonist KMUP-1 (7-{2-[4-(2 ...
Chung-Pin Liu, Zen-Kong Dai, Chein-Heng Huang, Jwu-Lai Yeh, Bin-Nan Wu, Jiunn-Ren Wu, Ing-Jun Chen   +6 more
doaj   +1 more source