In-Vitro evaluation of hydroalcoholic extract of Allium ampeloprasum on rat ileum contractions [PDF]
, 2014 Background: Ampeloprasum is traditionally used for gastrointestinal disorders. In this experimental study, the effect of ethanolic extract of Allium ampeloprasum was investigated on the rat ileum contractions. The mechanisms were also evaluated. Methods:
Hadi, Molouk. +4 more
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Rat duodenal motility in vitro: Prokinetic effects of DL-homocysteine thiolactone and modulation of nitric oxide mediated inhibition [PDF]
, 2013 Homocysteine is a significant but modifiable risk factor for vascular diseases. As gastrointestinal smooth musculature is similar to blood vessel muscles, we investigated how elevated homocysteine levels affect nitric oxide-mediated ...
Ilić S. +7 more
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Physiological Reports, Volume 12, Issue 18, September 2024.The vasoactive response to the nonsteroidal mineralocorticoid receptor antagonist (MRA) finerenone was tested ex vivo in arteries of human visceral adipose tissue (VAT). Finerenone elicited endothelium‐independent vasorelaxation in arteries precontracted with different vasoconstrictors; the steroidal MRA potassium canrenoate, by contrast, did not relax
Francesca Schinzari +5 more
wiley +1 more source
Role of an indole-thiazolidine molecule PPAR pan-agonist and COX inhibitor on inflammation and microcirculatory damage in acute gastric lesions. [PDF]
PLoS ONE, 2013 The present study aimed to show the in vivo mechanisms of action of an indole-thiazolidine molecule peroxisome-proliferator activated receptor pan-agonist (PPAR pan) and cyclooxygenase (COX) inhibitor, LYSO-7, in an ethanol/HCl-induced (Et/HCl) gastric ...
José Roberto Santin +7 more
doaj +1 more source
Oliveria decumbens, a Long‐Neglected Plant with Promising Phytochemical and Biological Properties
Chemistry &Biodiversity, Volume 21, Issue 7, July 2024.Abstract Oliveria decumbens is a folkloric medicinal plant belonging to the Apiaceae family, traditionally utilized to treat various diseases like gastrointestinal disorders, fever, and wounds. This review aims to provide a comprehensive overview of the plant‘s phytochemical composition and biological properties, with potential implications for various
Anahita Boveiri Dehsheikh +4 more
wiley +1 more source
Bixa orellana leaf extract suppresses histamine-induced endothelial hyperpermeability via the PLC-NO-cGMP signaling cascade [PDF]
, 2015 BACKGROUND: Histamine is established as a potent inflammatory mediator and it is known to increased endothelial permeability by promoting gap formation between endothelial cells.
Hoe Siong Chiong +3 more
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Advanced Science, Volume 11, Issue 21, June 5, 2024.The down‐regulation of THBS1 can destabilize TAK1 via NEDD4‐mediated, K48‐linked TAK1 ubiquitination, resulting in the activation of the necroptosis and DAMPs release in trophoblast cells, thus participating in the pathogenesis of PE. Abstract Preeclampsia (PE) is considered as a disease of placental origin. However, the specific mechanism of placental
Haoyue Hu +15 more
wiley +1 more source
Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS. [PDF]
PLoS ONE, 2012 The hormone, relaxin, inhibits aberrant myofibroblast differentiation and collagen deposition by disrupting the TGF-β1/Smad2 axis, via its cognate receptor, Relaxin Family Peptide Receptor 1 (RXFP1), extracellular signal-regulated kinase (ERK)1/2 ...
Bryna Suet Man Chow +5 more
doaj +1 more source
Protective effect of picroside II on myocardial ischemia reperfusion injury in rats
Drug Design, Development and Therapy, 2014 Nan Wu, Wenna Li, Wenqi Shu, Dalin Jia Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China Abstract: The aim of this study was to determine the effect of picroside II on ...
Wu N, Li W, Shu W, Jia D
doaj
Reduction–oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics [PDF]
, 2018 Every year, millions of cancer patients undergo radiation therapy for treating and destroying abnormal cell growths within normal cell environmental conditions.
Abdollahi, H. +10 more
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