Results 91 to 100 of about 7,513 (165)

P38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity [PDF]

, 2014
Background Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease.
Ming, Xiu-Fen, Montani, Jean-Pierre, Rajapakse, Angana G., Yang, Zhihong, Yu, Yi   +4 more
core   +2 more sources

Ginsenoside Re inhibits pacemaker potentials via adenosine triphosphate-sensitive potassium channels and the cyclic guanosine monophosphate/nitric oxide-dependent pathway in cultured interstitial cells of Cajal from mouse small intestine

Journal of Ginseng Research, 2015
Background: Ginseng belongs to the genus Panax. Its main active ingredients are the ginsenosides. Interstitial cells of Cajal (ICCs) are the pacemaker cells of the gastrointestinal (GI) tract.
Noo Ri Hong, Hyun Soo Park, Tae Seok Ahn, Hyun Jung Kim, Ki-Tae Ha, Byung Joo Kim   +5 more
doaj   +1 more source

Suppressive effects of Mimosa pudica (L.) constituents on the production of LPS-induced pro-inflammatory mediators [PDF]

, 2014
The present study deals with the isolation of fourteen compounds from the active ethyl acetate (MPE) extract of M. pudica (L.) whole plant and their subsequent evaluation for the nitric oxide (NO), tumor necrosis factor alpha (TNF-α) and interleukin 1 ...
Bhutani, Kamlesh K., Patel, Neeraj K.
core  

Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion [PDF]

, 2013
Funding Information: Source of funding The study received partial support from FTC (Fundação para a Ciência e a Tecnologia - Portuguese Foundation for Science and Technology) under the project PTDC/DTP-EPI/0207/2012.
Baldi, S., Ferrannini, E., Macedo, M. P., Mari, A., Natali, A., Ribeiro, R., Rossi, M., Tulipani, A., Venturi, E.   +8 more
core   +1 more source

Effect of L-Arginine and L-NAME treatments on polymorphonuclear leukocytes and mononuclear cells influx during tumor growth Efeito dos tratamentos com L-Arginina e L-NAME sobre o influxo de leucócitos polimorfonucleares e células mononucleares durante o desenvolvimento tumoral

Acta Cirúrgica Brasileira, 2009
PURPOSE: Evaluate polymorphonuclear leukocytes (PMN's) and mononuclear cells (MN's) involvement in the Ehrlich´s solid tumor (ET) growth. METHODS: 90 Swiss mice were inoculated with 10(7) tumor cells (sc), distributed in three groups and treated once a ...
Olívia Teixeira Gomes Reis, Juliana Crepaldi Raini, Silvana Torossian Coradi, Dulce Helena Jardim Constantino   +3 more
doaj   +1 more source

GLIAL HEMICHANNELS: A NEW ROUTE FOR CHEMICAL COMMUNICATION IN BRAIN [PDF]

, 2008
The extracellular neurochemistry determines normal brain function and the faith of neurons after insults such as stroke. This thesis concerns the effect of extracellular events related to intense neuronal stimulation and stroke, i.e.
Stridh, Malin
core   +1 more source

Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model

Kaohsiung Journal of Medical Sciences, 2014
This study investigates whether endothelin-1 (ET-1) mediates monocrotaline (MCT)-induced pulmonary artery hypertension (PAH) and right ventricular hypertrophy (RVH), and if so, whether the G-protein coupled receptor antagonist KMUP-1 (7-{2-[4-(2 ...
Chung-Pin Liu, Zen-Kong Dai, Chein-Heng Huang, Jwu-Lai Yeh, Bin-Nan Wu, Jiunn-Ren Wu, Ing-Jun Chen   +6 more
doaj   +1 more source

The PD-1/PD-L1 inhibitory pathway is altered in pre-eclampsia and regulates T cell responses in pre-eclamptic rats

Scientific Reports, 2016
The programmed cell death-1(PD-1)/PD-ligand 1 (PD-L1) pathway is critical to immune homeostasis by promoting regulatory T (Treg) development and inhibiting effector T (such as Th17) cell responses.
Mei Tian, Yong‐Hong Zhang, Zhaozhao Liu, Guoqiang Sun, G. Mor, A. Liao   +5 more
semanticscholar   +1 more source

The Effects of L-Arginine (the Precursor of Nitric Oxide) and L-NAME (Nitric Oxide Synthase Inhibitor) on Coronary Angiogenesis in Normal Rats

مجله دانشکده پزشکی اصفهان, 2012
Background: Nitric oxide (NO) has beneficial effects on cardiovascular system including improvement of angiogenesis. The aim of this study was to evaluate the effects of L-arginine (the precursor of NO) and L-NG-nitroarginine methyl ester (L-NAME) (NO ...
Majid Khazaei, Mohammad Amin Moshayedi, Massoud Teimouri, Shahrzad Aghili, Saeed Montazeri, Roshanak Mehdipour, Fazolah Hashemzehi, Hourossadat Hashemi Jazi   +7 more
doaj  

Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications [PDF]

, 2015
SIGNIFICANCE Enhanced levels of reactive oxygen species (ROS) have been associated with different disease states. Most attempts to validate and exploit these associations by chronic antioxidant therapies have provided disappointing results. Hence, the
Ana I. Casas, Andreas Daiber, Antonio Cuadrado, Brunner HG, Fabio Di Lisa, Ghassan J. Maghzal, Hampton MB, Harald H.H.W. Schmidt, Hou YC, Karl H. Krause, Klebanoff SJ., Liu VW, Manuela G. López, Nina Kaludercic, Pietro Ghezzi, Roland Stocker, Sandler M, Savenkova ML, Sonia Leach, Tamara Seredenina, V. Thao-Vi Dao, Vincent Jaquet   +21 more
core   +3 more sources