Human Vascular Microphysiological System for in vitro Drug Screening
Scientific Reports, 2016 In vitro human tissue engineered human blood vessels (TEBV) that exhibit vasoactivity can be used to test human toxicity of pharmaceutical drug candidates prior to pre-clinical animal studies.
Cristina E Fernandez +6 more
semanticscholar +1 more source
Cortical spreading depression as a target for anti-migraine agents [PDF]
, 2014 Spreading depression (SD) is a slowly propagating wave of neuronal and glial depolarization lasting a few minutes, that can develop within the cerebral cortex or other brain areas after electrical, mechanical or chemical depolarizing stimulations ...
Ayata, Cenk +6 more
core +1 more source
Exercise-induced pulmonary hemorrhage: where are we now? [PDF]
, 2016 Citation: Poole, D. C., & Erickson, H. H. (2016). Exercise-induced pulmonary hemorrhage: where are we now? Veterinary Medicine-Research and Reports, 7, 133-148.
Erickson, Howard H., Poole, David C.
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Biochemical Assay Optimization and Computational Screening Efforts to Identify Potential LuxS Inhibitors [PDF]
, 2013 Quorum sensing (QS) is a process of coordination of bacterial gene expression in response to cell population. System two QS is regulated by the small signaling molecule autoinducer-2 (AI-2) and is implicated in the infectious behaviors of various ...
Wang, Keeshia Q
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Regulatory Mechanisms in Biosystems, 2018 The processes of effect of L-arginine-L-glutamate on peroxidation and slime-forming function of the stomach cells, the system of antioxidant defense in the blood, liver and brain tissues of rats with experimental pathology of the gastroduodenal zone have
Y. M. Stepanov +5 more
doaj +1 more source
Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. [PDF]
, 2015 Endothelial dysfunction is a critical factor in many cardiovascular diseases, including hypertension. Although lipid signaling has been implicated in endothelial dysfunction and cardiovascular disease, specific molecular mechanisms are poorly understood.
Bucci M +9 more
core +1 more source
Gut microbiota-derived trimethylamine N-Oxide: a novel target for the treatment of preeclampsia
Gut MicrobesPre-eclampsia (PE) is the most common complication of pregnancy and seriously threatens the health and safety of the mother and child. Studies have shown that an imbalance in gut microbiota can affect the progression of PE.
Jiayi Wang +8 more
doaj +1 more source
Effects of the Nitric Oxide Synthease Inhibitor NG-nitro-L-arginine on the Erectile Response to Cavernous Nerve Stimulation in the Rabbit [PDF]
, 1991 Anderson, J. M. +3 more
core +1 more source
Improvement of tissue survival of skin flaps by 5α-reductase inhibitors: Possible involvement of nitric oxide and inducible nitric oxide synthase [PDF]
, 2015 Background: Skin flap grafting is a popular approach for reconstruction of critical skin and underlying soft tissue injuries. In a previous study, we demonstrated the beneficial effects of two 5α-reductase inhibitors, azelaic acid and finasteride, on ...
Aboutaleb, N. +6 more
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Structure-function study of ubiquitin c-terminal hydrolase L1 (UCH-L1) by NMR spectroscopy - insights into UCH-L1 mutation's association with the risk of Parkinson's disease [PDF]
, 2012 Poster Presentation: P72Protein ubiquitination and deubiquitination, play important roles in many aspects of cellular mechanisms. Its defective regulation results in diseases that range from developmental abnormalities to neurodegenerative diseases and ...
Hu, HY, Sze, KH, Tse, HS
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