Results 31 to 40 of about 7,513 (165)

Perturbations in nitric oxide homeostasis promote Arabidopsis disease susceptibility towards Phytophthora parasitica

open access: yesMolecular Plant Pathology, Volume 22, Issue 9, Page 1134-1148, September 2021., 2021
Perturbations in Arabidopsis nitric oxide homeostasis promote disease susceptibility towards the oomycete pathogen Phytophthora parasitica. Abstract Phytophthora species can infect hundreds of different plants, including many important crops, causing a number of agriculturally relevant diseases.
Beimi Cui   +12 more
wiley   +1 more source

Compromised Cortical-Hippocampal Network Function From Transient Hypertension: Linking Mid-Life Hypertension to Late Life Dementia Risk

open access: yesFrontiers in Neuroscience, 2022
Mid-life hypertension is a major risk factor for developing dementia later in life. While anti-hypertensive drugs restore normotension, dementia risk remains above baseline suggesting that brain damage sustained during transient hypertension is ...
Aaron Y. Lai   +7 more
doaj   +1 more source

7-Nitro indazole, an inhibitor of neuronal nitric oxide synthase, attenuates pilocarpine-induced seizures [PDF]

open access: yes, 1995
7-Nitro indazole (25–100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system
Dzoljic, E. (Eleonora)   +2 more
core   +1 more source

Quercetin relaxes human gastric smooth muscles directly through ATP‐sensitive potassium channels and not depending on the nitric oxide pathway

open access: yesNeurogastroenterology &Motility, Volume 33, Issue 7, July 2021., 2021
Certain gastric smooth muscle relaxation pathways and their selective inhibitors. Abstract Background Quercetin has recently become a remarkably popular subject of research due to its broad beneficial pharmacological properties. The goal of our study was to observe its effects on contractility of human gastric smooth muscles in reference to the NO ...
Beata Modzelewska   +7 more
wiley   +1 more source

Gallic Acid Attenuates Angiotensin II-Induced Hypertension and Vascular Dysfunction by Inhibiting the Degradation of Endothelial Nitric Oxide Synthase

open access: yesFrontiers in Pharmacology, 2020
Hypertension is a major cause of heart attack and stroke. Our recent study revealed that gallic acid (GA) exerts protective effects on pressure overload-induced cardiac hypertrophy and dysfunction.
Xiao Yan   +6 more
doaj   +1 more source

Alamandine and Its Receptor MrgD Pair Up to Join the Protective Arm of the Renin-Angiotensin System [PDF]

open access: yes, 2019
Only a few years ago, alamandine was found to be a member of the protective arm of the renin-angiotensin system. It turned out to be an endogenous ligand of the G protein-coupled receptor MrgD.
Schleifenbaum, Johanna
core   +1 more source

The role of myeloid‐derived suppressor cells in gastrointestinal cancer

open access: yesCancer Communications, Volume 41, Issue 6, Page 442-471, June 2021., 2021
Gastrointestinal (GI) cancer encompasses a range of malignancies that originate in the digestive system, which together represent the most common form of cancer diagnosed worldwide. Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that increase in number under certain pathological conditions such as ...
Cheng Cui, Penglin Lan, Li Fu
wiley   +1 more source

Revisiting the expression and function of follicle-stimulation hormone receptor in human umbilical vein endothelial cells [PDF]

open access: yes, 2016
Expression of follicle-stimulation hormone receptor (FSHR) is confined to gonads and at low levels to some extragonadal tissues like human umbilical vein endothelial cells (HUVEC). FSH-FSHR signaling was shown to promote HUVEC angiogenesis and thereafter
Akerfelt, Malin   +11 more
core   +1 more source

Correlational Study of Aminopeptidase Activities between Left or Right Frontal Cortex versus the Hypothalamus, Pituitary, Adrenal Axis of Spontaneously Hypertensive Rats Treated with Hypotensive or Hypertensive Agents [PDF]

open access: yes, 2023
Supplementary Materials: The supporting information can be downloaded at: https://www.mdpi. com/article/10.3390/ijms242116007/s1It has been suggested that the neuro-visceral integration works asymmetrically and that this asymmetry is dynamic and ...
Domínguez Vías, German   +3 more
core   +4 more sources

Proteolytic activity of Triatoma infestans saliva associated with PAR-2 activation and vasodilation [PDF]

open access: yesJournal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background Triatoma infestans (Hemiptera: Reduviidae) is a hematophagous insect and the main vector of Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae). In the present study, the authors investigated whether a serine protease activity from the saliva
Karla A. Oliveira   +11 more
doaj   +1 more source

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