Results 111 to 120 of about 43,908 (154)
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The telling tail of L-selectin
Biochemical Society Transactions, 2004L-selectin is constitutively expressed on the surface of most leucocytes and is important for tethering and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs (e.g. naive T cells) and sites of inflammation (e.g. neutrophils).
A, Ivetic, A J, Ridley
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Effect of uremia and hemodialysis on soluble L-selectin and leukocyte surface CD11b and L-selectin
American Journal of Kidney Diseases, 1998Leukocyte Mac-1 (CD11b/CD18) and L-selectin (CD62L) are implicated in leukocyte adhesion to endothelial cells. In this study, L-selectin and CD11b expression on leukocytes and soluble L-selectin (sL-selectin) serum levels were investigated in 17 nondialyzed patients with chronic renal failure (CRF), in 28 chronic hemodialysis patients before ...
Dou, Laetitia +4 more
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The association of L-selectin polymorphisms with L-selectin serum levels and risk of ischemic stroke
Journal of Thrombosis and Thrombolysis, 2011L-selectin is a member of the selectin family of cell adhesion molecules which are important in the transient attachment of leukocytes to endothelial cells, which plays a role in inflammation processes and is one of the earliest events in the pathogenesis of atherosclerosis.
Ye-Sheng, Wei +3 more
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The Journal of Trauma: Injury, Infection, and Critical Care, 1998
To examine (1) the effects of trauma on changes in neutrophil L-selectin and CD11b expression and on the levels of soluble L-selectin and (2) whether these alterations are different on leukocyte subpopulations in those patients who develop multiple organ dysfunction syndrome.Twenty patients with Injury Severity Score (ISS) > or = 16 and 15 patients ...
K, Maekawa +6 more
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To examine (1) the effects of trauma on changes in neutrophil L-selectin and CD11b expression and on the levels of soluble L-selectin and (2) whether these alterations are different on leukocyte subpopulations in those patients who develop multiple organ dysfunction syndrome.Twenty patients with Injury Severity Score (ISS) > or = 16 and 15 patients ...
K, Maekawa +6 more
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L-selectin in health and disease
Resuscitation, 2002This article reviews recent advances in the knowledge of the role of L-selectin, an adhesion molecule that is expressed on the surface of circulating leucocytes, in animal and human physiology and pathophysiology. After a brief discussion on nomenclature and structure, it progresses through the evidence for expression and regulation of L-selectin, cell
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L‐Selectin: An Emerging Player in Chemokine Function
Microcirculation, 2003ABSTRACTThe emigration of leukocytes across the blood‐endothelium barrier and their subsequent transmigration through the interstitium is a complex process that is vital for maintaining the efficiency of the body's innate and adaptive immunity. The chemokines, a family of low‐molecular‐weight chemoattractant cytokines, are well recognized to be key ...
Adil I, Khan, Paul, Kubes
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The L-selectin adhesion system
Current Opinion in Hematology, 1995L-selectin is a cell surface glycoprotein expressed on most leukocyte subsets that mediates leukocyte interaction with ligands on lymphoid tissue high endothelial venule cells as well as with ligands on activated endothelium at sites of inflammation in nonlymphoid organs.
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Structure and function of L‐selectin
APMIS, 1992The selectins are a newly described family of carbohydrate‐binding adhesion molecules involved in the regulation of leukocyte traffic. Selectins are composed of an N‐terminal C‐type lectin domain, a single EGF domain, a variable number of short concensus repeat (SCR) domains, a transmembrane region and a cytoplasmic tail.
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Nephron, 2008
L-selectin and Mac-1 expressed on leukocytes are critical for leukocyte adhesion to inflamed endothelium. L-selectin is known to be rapidly shed from the cell surface of granulocytes after activation. In the present study the change of expressions of these adhesion molecules on granulocytes were analyzed by flow cytometry, and the serum concentration ...
K, Kawabata +4 more
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L-selectin and Mac-1 expressed on leukocytes are critical for leukocyte adhesion to inflamed endothelium. L-selectin is known to be rapidly shed from the cell surface of granulocytes after activation. In the present study the change of expressions of these adhesion molecules on granulocytes were analyzed by flow cytometry, and the serum concentration ...
K, Kawabata +4 more
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Adrenaline upregulates monocyte L-selectin in vitro
Resuscitation, 1999Although surface adhesion molecules mediate leucocyte-endothelial interactions at sites of inflammation, relatively little is known of the factors which increase the expression of L-selectin in circulating leucocytes. The expression of leucocyte L-selectin increases during acute stress events such as injury and is temporally related to an early ...
T H, Rainer, N, Lam, R A, Cocks
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