Results 201 to 210 of about 475,176 (250)

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

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The role of L-serine dehydratase in the metabolism of L-serine in the perfused rat liver

Biochimica et Biophysica Acta (BBA) - General Subjects, 1971
Abstract 1. 1. To determine the role of L -serine dehydratase ( L -serine hydrolyase, deaminating, EC 4.2.1.13) in L -serine metabolism in the rat liver, experiments involving in situ liver perfusion, metabolite measurement in freeze-clamped tissues and enzyme activity determinations were conducted. 2. 2.
T M, Chan, R A, Freedland
openaire   +2 more sources

Effects of l-serine on neurons in vitro

Journal of Neuroscience Methods, 1995
We have examined the influence of amino acids on chicken embryonic dorsal root ganglion (DRG) neurons in vitro and have found that serine has a marked impact on the morphology of the developing neurites. In cultures supplemented with L-serine (but not D-serine) at micromolar concentrations (10-200 microM), the length of the neurites was increased by up
Savoca, R, Ziegler, U, Sonderegger, P
openaire   +4 more sources

l-serine picrates

Journal of Molecular Structure, 2015
Abstract Two crystalline salts have been obtained from the system l -serine - picric acid - H2O: l -serinium picrate monohydrate (I) and tris( l -serine) bis( l -serinium) dipicrate trihydrate (II). The salt (I) crystallizes in monoclinic system (space group P21, Z = 4). Asymmetric unit of (I) contains two formula units. Carboxyl groups of both l -
B.A. Zakharov, V.V. Ghazaryan, E.V. Boldyreva, A.M. Petrosyan   +3 more
openaire   +1 more source

l-serine dehydratase and l-serine-pyruvate aminotransferase activities in different animal species

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1979
1. A rough inverse correlation between liver serine dehydratase activity and species body size was observed with mammals. This was not found for glutamate, malate or lactate dehydrogenase, fumarase or aspartate-2-oxoglutarate aminotransferase. Serine dehydratase (and certain liver aminotransferases showing a similar species-size dependence) may have a ...
Gregory, Kathleen, Rowsell, E. V., Carnie, J. A., Wahbi, S. D., Al-Tai, A. H., Rowsell, Kathleen V.   +5 more
openaire   +3 more sources

Spectroscopic, theoretical and structural characterization of hydrogensquarates of l-threonyl-l-serine and l-serine

Amino Acids, 2007
Hydrogensquarates of dipeptide L-threonyl-L-serine (H-Thr-Ser-OH) and L: -serine (HSq x Ser) have been synthesized, isolated and spectroscopic characterized by solid-state linear-polarized IR-spectroscopy, 1H- and 13C-NMR, ESI-MS and HPLC with tandem masspectrometry (MS-MS) methods.
T, Kolev, B B, Koleva, M, Spiteller
openaire   +2 more sources

Adsorption of O-Phospho-L-Serine and L-Serine onto Poorly Crystalline Apatite

Journal of Colloid and Interface Science, 2001
The adsorption of phosphoserine and serine was studied to determine the effect of amino acid functional groups on the surface reactivity of synthetic poorly crystalline apatite similar to bone mineral. The experimental results for phosphoserine and serine uptake agree respectively with the Langmuir and Freundlich models. Phosphoserine exhibits stronger
Lhaj, Benaziz, Allal, Barroug, Ahmed, Legrouri, Christian, Rey, Albert, Lebugle   +4 more
openaire   +2 more sources