Predictive value of serum d-serine level for hearing impairment in uremic patients [PDF]
Renal Failure, 2023 Objective To investigate the predictive value of serum d-serine level for hearing impairment (HI) in uremic patients.Methods In this study, 30 uremic patients with HI and 30 with normal hearing were selected. The basic conditions, biochemical indicators,
Jiaqing Li +6 more
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Endothelial SLC38A2 controls brain D-serine homeostasis and synapse development [PDF]
iScienceSummary: L-serine is a precursor for the synthesis of the neuromodulator D-serine, glycine, and lipids. Contrary to the prevailing view that brain L-serine is exclusively derived from de novo synthesis, we demonstrate that dietary L-serine is required to
Akshay K. Tiwari +12 more
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ASC Transporters Mediate D-Serine Transport into Astrocytes Adjacent to Synapses in the Mouse Brain [PDF]
Biomolecules, 2023 D-serine is an important signalling molecule, which activates N-methyl D-aspartate receptors (NMDARs) in conjunction with its fellow co-agonist, the neurotransmitter glutamate.
Karthik Subramanian Krishnan +1 more
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Glial D-serine modulates oligodendrocyte lineage progression under inflammatory conditions [PDF]
Frontiers in Cellular NeuroscienceInflammatory environments may shape oligodendrocyte lineage dynamics beyond classical cytokine signaling, in part through the release of glial neuromodulators.
Juan Pablo Espinoza +5 more
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Astrocytes control hippocampal synaptic plasticity through the vesicular-dependent release of D-serine [PDF]
Frontiers in Cellular Neuroscience, 2023 Astrocytes, the most abundant glial cells in the central nervous system (CNS), sense synaptic activity and respond through the release of gliotransmitters, a process mediated by intracellular Ca2+ level changes and SNARE-dependent mechanisms.
Daniela Sofia Abreu +11 more
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Excitatory and inhibitory D-serine binding to the NMDA receptor [PDF]
eLife, 2022 N-methyl-D-aspartate receptors (NMDARs) uniquely require binding of two different neurotransmitter agonists for synaptic transmission. D-serine and glycine bind to one subunit, GluN1, while glutamate binds to the other, GluN2.
Remy A Yovanno +4 more
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The effects of the NMDAR co-agonist d-serine on the structure and function of optic tectal neurons in the developing visual system [PDF]
Scientific Reports, 2023 The N-methyl-d-aspartate type glutamate receptor (NMDAR) is a molecular coincidence detector which converts correlated patterns of neuronal activity into cues for the structural and functional refinement of developing circuits in the brain.
Zahraa Chorghay +4 more
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Physiopathological Relevance of D-Serine in the Mammalian Cochlea [PDF]
Frontiers in Cellular Neuroscience, 2021 NMDA receptors (NMDARs) populate the complex between inner hair cell (IHC) and spiral ganglion neurons (SGNs) in the developing and mature cochlea.
Jing Wang +9 more
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Serum d-serine and d-amino acid oxidase (DAO) levels in schizophrenia and related psychotic disorders: a 6-month follow-up study [PDF]
European PsychiatryIntroduction D-serine and the DAO enzyme may impact the NMDA receptor and contribute to schizophrenia, but the exact role and outcomes are not fully understood due to the complexity of the disorder. Objectives We analyzed serum levels of d-serine and
E. Uzun Uysal +3 more
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D-Serine: A Cross Species Review of Safety
Frontiers in Psychiatry, 2021 Background:D-Serine, a direct, full agonist at the D-serine/glycine modulatory site of the N-methyl-D-aspartate-type glutamate receptors (NMDAR), has been assessed as a treatment for multiple psychiatric and neurological conditions.
Amir Meftah +5 more
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