Physiopathological Relevance of D-Serine in the Mammalian Cochlea [PDF]
Frontiers in Cellular Neuroscience, 2021 NMDA receptors (NMDARs) populate the complex between inner hair cell (IHC) and spiral ganglion neurons (SGNs) in the developing and mature cochlea.
Jing Wang +9 more
doaj +6 more sources
Predictive value of serum d-serine level for hearing impairment in uremic patients [PDF]
Renal Failure, 2023 Objective To investigate the predictive value of serum d-serine level for hearing impairment (HI) in uremic patients.Methods In this study, 30 uremic patients with HI and 30 with normal hearing were selected. The basic conditions, biochemical indicators,
Jiaqing Li +6 more
doaj +2 more sources
D-Serine as a sensor and effector of the kidney. [PDF]
Clin Exp Nephrol, 2023 Abstractd-Serine, a rare enantiomer of serine, is a biomarker of kidney disease and function. The level of d-serine in the human body is precisely regulated through the urinary clearance of the kidney, and its clearance serves as a new measure of glomerular filtration rate with a lower bias than creatinine clearance.
Kimura T, Sakai S, Isaka Y.
europepmc +3 more sources
D-Serine: A Cross Species Review of Safety [PDF]
Frontiers in Psychiatry, 2021 Background:D-Serine, a direct, full agonist at the D-serine/glycine modulatory site of the N-methyl-D-aspartate-type glutamate receptors (NMDAR), has been assessed as a treatment for multiple psychiatric and neurological conditions.
Amir Meftah +5 more
doaj +2 more sources
ASC Transporters Mediate D-Serine Transport into Astrocytes Adjacent to Synapses in the Mouse Brain [PDF]
Biomolecules, 2023 D-serine is an important signalling molecule, which activates N-methyl D-aspartate receptors (NMDARs) in conjunction with its fellow co-agonist, the neurotransmitter glutamate.
Karthik Subramanian Krishnan +1 more
doaj +2 more sources
Astrocytes control hippocampal synaptic plasticity through the vesicular-dependent release of D-serine [PDF]
Frontiers in Cellular Neuroscience, 2023 Astrocytes, the most abundant glial cells in the central nervous system (CNS), sense synaptic activity and respond through the release of gliotransmitters, a process mediated by intracellular Ca2+ level changes and SNARE-dependent mechanisms.
Daniela Sofia Abreu +11 more
doaj +2 more sources
Glial D-serine modulates oligodendrocyte lineage progression under inflammatory conditions [PDF]
Frontiers in Cellular NeuroscienceInflammatory environments may shape oligodendrocyte lineage dynamics beyond classical cytokine signaling, in part through the release of glial neuromodulators.
Juan Pablo Espinoza +5 more
doaj +2 more sources
The effects of the NMDAR co-agonist d-serine on the structure and function of optic tectal neurons in the developing visual system [PDF]
Scientific Reports, 2023 The N-methyl-d-aspartate type glutamate receptor (NMDAR) is a molecular coincidence detector which converts correlated patterns of neuronal activity into cues for the structural and functional refinement of developing circuits in the brain.
Zahraa Chorghay +4 more
doaj +2 more sources
Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL–G–F/NL–G–F mice [PDF]
Frontiers in Aging Neuroscience, 2023 BackgroundNeurodegenerative processes in Alzheimer’s disease (AD) are associated with excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR). D-Serine is an endogenous co-agonist necessary for NMDAR-mediated excitotoxicity. In the mammalian
Xiance Ni +19 more
doaj +2 more sources
Excitatory and inhibitory D-serine binding to the NMDA receptor [PDF]
eLife, 2022 N-methyl-D-aspartate receptors (NMDARs) uniquely require binding of two different neurotransmitter agonists for synaptic transmission. D-serine and glycine bind to one subunit, GluN1, while glutamate binds to the other, GluN2.
Remy A Yovanno +4 more
doaj +2 more sources