Results 31 to 40 of about 10,883,538 (292)

Overdose of D-serine Induces Movement Disorder and Neuromuscular Changes of Zebrafish Larvae [PDF]

, 2014
D-serine is a well-known activator of N-methyl-D-aspartate receptors; however, little is known about the teratogenic effects of D-serine overdose during early embryonic development.
Chen, Xing-Guang; Wang, Yun-Hsin; Wen, Chi-Chung; Chen, Yau-Hung, Chi-Chung Wen, Yun-Hsin Wang, Xing-Guang Chen, Yau-Hung Chen   +4 more
core   +1 more source

D-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology

Neurology Research International, 2012
In mammalian systems, D-serine is perhaps the most biologically active D-amino acid described to date. D-serine is a coagonist at the NMDA-receptor, and receptor activation is dependent on D-serine binding. Because D-serine binding dramatically increases
John P. Crow, John C. Marecki, Misty Thompson   +2 more
doaj   +1 more source

D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. [PDF]

PLoS ONE, 2016
N-methyl-D-aspartate (NMDA) receptors play critical roles in synaptic transmission and plasticity. Activation of NMDA receptors by synaptically released L-glutamate also requires occupancy of co-agonist binding sites in the tetrameric receptor by either ...
Alan C Foster, Jill Farnsworth, Genevieve E Lind, Yong-Xin Li, Jia-Ying Yang, Van Dang, Mahmud Penjwini, Veena Viswanath, Ursula Staubli, Michael P Kavanaugh   +9 more
doaj   +1 more source

Crystalline d-Serine Dehydrase

Journal of Biological Chemistry, 1966
Abstract A procedure is described for the preparation of crystalline d-serine dehydrase from mutant C6 of Escherichia coli K-12, a constitutive mutant for this enzyme. The molecular weight is 37,300, and 1 mole of pyridoxal 5-phosphate is bound per mole of enzyme.
R, Labow, W G, Robinson
openaire   +2 more sources

d-serine in physiological and pathological brain aging

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2021
Among aging-induced impairments, those affecting cognitive functions certainly represent one the most major challenge to face to improve elderly quality of life. In last decades, our knowledge on changes in the morphology and function of neuronal networks associated with normal and pathological brain aging has rapidly progressed, initiating the ...
Ploux, E., Freret, T, Billard, Jean-Marie   +2 more
openaire   +5 more sources

Heterogeneity of D-Serine Distribution in the Human Central Nervous System

ASN Neuro, 2017
D-serine is an endogenous ligand for N -methyl-D-aspartate glutamate receptors. Accumulating evidence including genetic associations of D-serine metabolism with neurological or psychiatric diseases suggest that D-serine is crucial in human ...
Masataka Suzuki, Nobuaki Imanishi, Masashi Mita, Kenji Hamase, Sadakazu Aiso, Jumpei Sasabe   +5 more
doaj   +1 more source

Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila.

Curr Biol, 2022
Thirst emerges from a range of cellular changes that ultimately motivate an animal to consume water. Although thirst-responsive neuronal signals have been reported, the full complement of brain responses is unclear.
Park A, Croset V, Otto N, Agarwal D, Treiber CD, Meschi E, Sims D, Waddell S.   +7 more
europepmc   +2 more sources

Capitao_supplementary_information – Supplemental material for A single administration of ‘microbial’ D-alanine to healthy volunteers augments reaction to negative emotions: A comparison with D-serine

, 2020
Supplemental material, Capitao_supplementary_information for A single administration of ‘microbial’ D-alanine to healthy volunteers augments reaction to negative emotions: A comparison with D-serine by Liliana P Capitão, Jessica Forsyth, Mia A Thomaidou,
Mark D Condon (8577036), Philip WJ Burnet (8577039), Mia A Thomaidou (8577033), Liliana P Capitão (8577027), Jessica Forsyth (8577030), Catherine J Harmer (6053075)   +5 more
core   +1 more source

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]

, 2003
Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Eggen, BJL, Vellenga, E, Vellenga, Edo,, Vogelzang, Irma, Eggen, BJL; id_orcid, Vogelzang, Irma,, Wierenga, Albertus T.J., Wierenga, Albertus T.J.,, Eggen, Bart J.L.,   +8 more
core   +1 more source

d-Serine: A key to synaptic plasticity? [PDF]

The International Journal of Biochemistry & Cell Biology, 2012
Two discoveries have put D-serine in the spotlight of neuroscience. First, D-serine was detected in brain tissue at high levels. Second, it was found to act on the N-methyl-D-aspartate receptor (NMDAR). This receptor is central to use-dependent synaptic plasticity, the cellular process which is widely believed to underlie learning.
Christian, Henneberger, Lucie, Bard, Dmitri A, Rusakov   +2 more
openaire   +2 more sources