D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. [PDF]
PLoS ONE, 2016 N-methyl-D-aspartate (NMDA) receptors play critical roles in synaptic transmission and plasticity. Activation of NMDA receptors by synaptically released L-glutamate also requires occupancy of co-agonist binding sites in the tetrameric receptor by either ...
Alan C Foster +9 more
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Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo [PDF]
, 2013 N-methyl-d-aspartate receptor (NMDAR) activation can initiate changes in synaptic strength, evident as long-term potentiation (LTP), and is a key molecular correlate of memory formation.
Kerry L. Spear +15 more
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D-Serine as a putative glial neurotransmitter [PDF]
Neuron Glia Biology, 2004 Abundant recent evidence favors a neurotransmitter/neuromodulator role for D-serine. D-serine is synthesized from L-serine by serine racemase in astrocytic glia that ensheath synapses, especially in regions of the brain that are enriched in NMDA-glutamate receptors.
Asif K, Mustafa +2 more
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Heterogeneity of D-Serine Distribution in the Human Central Nervous System
ASN Neuro, 2017 D-serine is an endogenous ligand for N -methyl-D-aspartate glutamate receptors. Accumulating evidence including genetic associations of D-serine metabolism with neurological or psychiatric diseases suggest that D-serine is crucial in human ...
Masataka Suzuki +5 more
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, 2020 Supplemental material, Capitao_supplementary_information for A single administration of ‘microbial’ D-alanine to healthy volunteers augments reaction to negative emotions: A comparison with D-serine by Liliana P Capitão, Jessica Forsyth, Mia A Thomaidou,
Mark D Condon (8577036) +5 more
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Significance of the D-Serine-Deaminase and D-Serine Metabolism of Staphylococcus saprophyticus for Virulence [PDF]
, 2013 Staphylococcus saprophyticus is the only species of Staphylococcus that is typically uropathogenic and possesses a gene coding for a D-serine-deaminase (DsdA).
Nielsen, Hailyn V +8 more
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Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL–G–F/NL–G–F mice
Frontiers in Aging Neuroscience, 2023 BackgroundNeurodegenerative processes in Alzheimer’s disease (AD) are associated with excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR). D-Serine is an endogenous co-agonist necessary for NMDAR-mediated excitotoxicity. In the mammalian
Xiance Ni +19 more
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Crystalline d-Serine Dehydrase
Journal of Biological Chemistry, 1966 Abstract A procedure is described for the preparation of crystalline d-serine dehydrase from mutant C6 of Escherichia coli K-12, a constitutive mutant for this enzyme. The molecular weight is 37,300, and 1 mole of pyridoxal 5-phosphate is bound per mole of enzyme.
R, Labow, W G, Robinson
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Contribution of serine racemase/d-serine pathway to neuronal apoptosis. [PDF]
, 2012 Recent data indicate that age-related N-methyl-d-aspartate receptor (NMDAR) transmission impairment is correlated with the reduction in serine racemase (SR) expression and d-serine content.
Borsello T +10 more
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d-serine in physiological and pathological brain aging
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2021 Among aging-induced impairments, those affecting cognitive functions certainly represent one the most major challenge to face to improve elderly quality of life. In last decades, our knowledge on changes in the morphology and function of neuronal networks associated with normal and pathological brain aging has rapidly progressed, initiating the ...
Ploux, E. +2 more
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