The Energy Landscape of Human Serine Racemase [PDF]
Frontiers in Molecular Biosciences, 2019 Human serine racemase is a pyridoxal 5′-phosphate (PLP)-dependent dimeric enzyme that catalyzes the reversible racemization of L-serine and D-serine and their dehydration to pyruvate and ammonia.
Samanta Raboni +2 more
exaly +10 more sources
Serine Racemase mediates subventricular zone neurogenesis via fatty acid metabolism [PDF]
Stem Cell Reports, 2023 The adult subventricular zone is a neurogenic niche that continuously produce newborn neurons. Here we show that serine racemase (SR), an enzyme that catalyzes the racemization of L-serine to D-serine and vice versa, affects neurogenesis in the adult SVZ
Robin Roychaudhuri, Solomon H Snyder
exaly +3 more sources
Sociality deficits in serine racemase knockout mice [PDF]
Brain and Behavior, 2019 Background Studies of schizophrenia have pointed to the role of glutamate in its pathophysiology. Mice lacking D‐serine show impairments in neurotransmission through NMDA receptors and display behaviors consistent with features of schizophrenia.
Tatyana M. Matveeva +4 more
doaj +5 more sources
Postsynaptic Serine Racemase Regulates NMDA Receptor Function. [PDF]
J Neurosci, 2020 d-serine is the primary NMDAR coagonist at mature forebrain synapses and is synthesized by the enzyme serine racemase (SR). However, our understanding of the mechanisms regulating the availability of synaptic d-serine remains limited.
Wong JM +7 more
europepmc +6 more sources
In Silico and In Vitro Screening of Serine Racemase Agonist and In Vivo Efficacy on Alzheimer’s Disease Drosophila melanogaster [PDF]
Pharmaceuticals, 2023 The NMDA receptor hypofunction has been implicated in schizophrenia, memory impairment, and Alzheimer’s disease. Modulating the abundance of D-serine, a co-agonist of the NMDA receptor, is a strategy to treat symptoms of the NMDA receptor hypofunction ...
Chih-Hao Lu +6 more
doaj +2 more sources
Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase [PDF]
Communications Biology, 2022 The catalytic mechanisms of human serine racemase reveal a ligandable pocket near Tyr121 that could be targeted for the development of novel inhibitors.
Chloe R. Koulouris +10 more
doaj +2 more sources
Induction of serine racemase expression and
Journal of Neuroinflammation, 2004 Background Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid β-peptide (Aβ), elicit a release of glutamate from microglia. We tested the possibility that a coagonist at the
Griffin W Sue T +5 more
doaj +2 more sources
Serine deamination by human serine racemase synergizes with antibiotics to curtail the replication of Chlamydia trachomatis. [PDF]
J Biol ChemThe obligate intracellular bacterium, Chlamydia trachomatis, has evolved to depend on its human host for many metabolites, including most amino acids and three of the four nucleotides.
Mott PD +4 more
europepmc +2 more sources
Serine racemase interaction with N-methyl-D-aspartate receptors antagonist reveals potential alternative target of chronic pain treatment: Molecular docking study [PDF]
Journal of Advanced Pharmaceutical Technology & Research, 2022 Serine racemase (SR) catalyzes L-serine racemization to activate the N-methyl-D-aspartate receptor (NMDAR). NMDAR activation is associated with the progression of acute-to-chronic neuropathic pain.
Ristiawan Muji Laksono +4 more
doaj +2 more sources
Journal of Pharmacological Sciences, 2008 Recent studies indicate that an endogenous co-agonist for an N-methyl-D-aspartate (NMDA) receptor–related glycine site, D-serine, is synthesized by serine racemase and is metabolized by D-amino acid oxidase (DAO) and that acute treatment with morphine ...
Masanobu Yoshikawa +7 more
doaj +2 more sources