Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase [PDF]
Communications Biology, 2022 The catalytic mechanisms of human serine racemase reveal a ligandable pocket near Tyr121 that could be targeted for the development of novel inhibitors.
Chloe R. Koulouris +10 more
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In Silico and In Vitro Screening of Serine Racemase Agonist and In Vivo Efficacy on Alzheimer’s Disease Drosophila melanogaster [PDF]
Pharmaceuticals, 2023 The NMDA receptor hypofunction has been implicated in schizophrenia, memory impairment, and Alzheimer’s disease. Modulating the abundance of D-serine, a co-agonist of the NMDA receptor, is a strategy to treat symptoms of the NMDA receptor hypofunction ...
Chih-Hao Lu +6 more
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The Energy Landscape of Human Serine Racemase [PDF]
Frontiers in Molecular Biosciences, 2019 Human serine racemase is a pyridoxal 5′-phosphate (PLP)-dependent dimeric enzyme that catalyzes the reversible racemization of L-serine and D-serine and their dehydration to pyruvate and ammonia.
Samanta Raboni +10 more
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Sociality deficits in serine racemase knockout mice [PDF]
Brain and Behavior, 2019 Background Studies of schizophrenia have pointed to the role of glutamate in its pathophysiology. Mice lacking D‐serine show impairments in neurotransmission through NMDA receptors and display behaviors consistent with features of schizophrenia.
Tatyana M. Matveeva +4 more
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Serine racemase interaction with N-methyl-D-aspartate receptors antagonist reveals potential alternative target of chronic pain treatment: Molecular docking study [PDF]
Journal of Advanced Pharmaceutical Technology & Research, 2022 Serine racemase (SR) catalyzes L-serine racemization to activate the N-methyl-D-aspartate receptor (NMDAR). NMDAR activation is associated with the progression of acute-to-chronic neuropathic pain.
Ristiawan Muji Laksono +4 more
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Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function [PDF]
Frontiers in Molecular Biosciences, 2019 Serine racemase (SR) is the first racemase enzyme to be identified in human biology and converts L-serine to D-serine, an important neuronal signaling molecule that serves as a co-agonist of the NMDA (N-methyl-D-aspartate) receptor.
Danielle L. Graham +3 more
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Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease [PDF]
Neurobiology of Disease, 2019 Although β-amyloid plaques are a well-recognized hallmark of Alzheimer's disease (AD) neuropathology, no drugs reducing amyloid burden have shown efficacy in clinical trials, suggesting that once AD symptoms emerge, disease progression becomes ...
Darrick T. Balu +11 more
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D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep [PDF]
Nature Communications, 2019 The physiological function of endogenous D-serine remains a mystery. Here the authors show that endogenous D-serine plays an important role in regulating sleep and that, while the D-serine synthesizing enzyme serine racemase (SR) is expressed both in the
Xihuimin Dai +5 more
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Serine racemase deletion alters adolescent social behavior and whole-brain cFos activation [PDF]
Frontiers in PsychiatryBackgroundNeurodevelopmental disorders (NDDs) can cause debilitating impairments in social cognition and aberrant functional connectivity in large-scale brain networks, leading to social isolation and diminished everyday functioning.
Stephanie E. Brown +12 more
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The Development of a Regulator of Human Serine Racemase for N-Methyl-D-aspartate Function [PDF]
BiomedicinesIt is crucial to regulate N-methyl-D-aspartate (NMDA) function bivalently depending on the central nervous system (CNS) conditions. CNS disorders with NMDA hyperfunction are involved in the pathogenesis of neurotoxic and/or neurodegenerative disorders ...
Lu-Ping Lu +9 more
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