Serine racemase: a key player in neuron activity and in neuropathologies
Frontiers in Bioscience, 2013 Serine racemase is the pyridoxal 5’-phosphatedependent enzyme that catalyzes L-serine racemisation to D-serine, and L- and D-serine beta-elimination in mammalian brain.
CAMPANINI, Barbara +3 more
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Human serine racemase is nitrosylated at multiple sites
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2018 Serine racemase is a pyridoxal 5'‐phosphate dependent enzyme responsible for the synthesis of d‐serine, a neuromodulator of the NMDA receptors. Its activity is modulated by several ligands, including ATP, divalent cations and protein interactors.
Mozzarelli, Andrea +17 more
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Antinociceptive Effect of Rat D-Serine Racemase Inhibitors, L-Serine-O-Sulfate, and L-Erythro-3-Hydroxyaspartate in an Arthritic Pain Model [PDF]
The Scientific World Journal, 2012 N-methyl-D-aspartic acid receptor (NMDAr) activation requires the presence of D-serine, synthesized from L-serine by a pyridoxal 5′-phosphate-dependent serine racemase (SR). D-serine levels can be lowered by inhibiting the racemization of L-serine.
Claudio Laurido +3 more
doaj +2 more sources
Changes in Serine Racemase-Dependent Modulation of NMDA Receptor: Impact on Physiological and Pathological Brain Aging [PDF]
Frontiers in Molecular Biosciences, 2018 The N-methyl-D-Aspartate glutamate receptors (NMDARs) are pivotal for the functional and morphological plasticity that are required in neuronal networks for efficient brain activities and notably for cognitive-related abilities.
Jean-Marie Billard
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PLoS ONE, 2013 BackgroundD-Serine, an endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, is synthesized from L-serine by serine racemase (SRR). Given the role of D-serine in both neurodevelopment and the pathophysiology of schizophrenia, we examined ...
Hiroko Hagiwara +2 more
doaj +2 more sources
Adolescent Exposure to a THC-Rich Cannabis Extract Produces Genotype-Dependent Effects on Cognition and Glial Morphology in Serine Racemase Mutant Mice. [PDF]
J NeurochemAdolescent exposure to a THC‐rich cannabis extract produced genotype‐dependent, contrasting effects in mice. In wild‐type animals, it altered behavior and brain glial cell structure, whereas in mice with a genetic deficiency in serine racemase, a model of impaired NMDA receptor signaling relevant to schizophrenia, it prevented cognitive and ...
Rangel IF +11 more
europepmc +2 more sources
Serine Racemase Expression by Striatal Neurons. [PDF]
Cell Mol Neurobiol, 2022 D-serine is synthesized by serine racemase (SR) and is a co-agonist at forebrain N-methyl-D-aspartate receptors (NMDARs). D-serine and SR are expressed primarily in neurons, but not in quiescent astrocytes. In this study, we examined the localization of D-serine and SR in the mouse striatum and the effects of genetically silencing SR expression in ...
Takagi S +4 more
europepmc +3 more sources
Serine deamination by human serine racemase synergizes with antibiotics to curtail the replication of Chlamydia trachomatis. [PDF]
J Biol ChemThe obligate intracellular bacterium, Chlamydia trachomatis, has evolved to depend on its human host for many metabolites, including most amino acids and three of the four nucleotides.
Mott PD +4 more
europepmc +2 more sources
Postsynaptic Serine Racemase Regulates NMDA Receptor Function. [PDF]
J Neurosci, 2020 d-serine is the primary NMDAR coagonist at mature forebrain synapses and is synthesized by the enzyme serine racemase (SR). However, our understanding of the mechanisms regulating the availability of synaptic d-serine remains limited.
Wong JM +7 more
europepmc +2 more sources
Regulation and dynamics of human serine racemase
, 2014 Human serine racemase (hSR), predominantly localized in neu-rons and astrocytes, is a dimeric pyridoxal 5’-phosphate (PLP) enzyme that catalyzes the reversible racemization of L-serine toD-serine, the physiologically relevant co-agonist of N-methyl-D ...
Marchetti, M +5 more
core +2 more sources