Serine racemase deletion alters adolescent social behavior and whole-brain cFos activation [PDF]
Frontiers in PsychiatryBackgroundNeurodevelopmental disorders (NDDs) can cause debilitating impairments in social cognition and aberrant functional connectivity in large-scale brain networks, leading to social isolation and diminished everyday functioning.
Stephanie E. Brown +12 more
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The Development of a Regulator of Human Serine Racemase for N-Methyl-D-aspartate Function [PDF]
BiomedicinesIt is crucial to regulate N-methyl-D-aspartate (NMDA) function bivalently depending on the central nervous system (CNS) conditions. CNS disorders with NMDA hyperfunction are involved in the pathogenesis of neurotoxic and/or neurodegenerative disorders ...
Lu-Ping Lu +9 more
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Mouse brain serine racemase catalyzes specific elimination ofL-serine to pyruvate
FEBS Letters, 2003 D-Serine was previously identified in mammalian brain and was shown to be a co-agonist at the ‘glycine’ site of the N-methyl-D-aspartate (NMDA)-type receptors.
Cyril Barinka +2 more
exaly +2 more sources
Conformational flexibility within the small domain of human serine racemase. [PDF]
Acta Crystallogr F Struct Biol Commun, 2020 Serine racemase (SR) is a pyridoxal 5′-phosphate (PLP)-containing enzyme that converts L-serine to D-serine, an endogenous co-agonist for the N-methyl-D-aspartate receptor (NMDAR) subtype of glutamate ion channels.
Koulouris CR, Bax BD, Atack JR, Roe SM.
europepmc +2 more sources
Increased excitation-inhibition balance and loss of GABAergic synapses in the serine racemase knockout model of NMDA receptor hypofunction. [PDF]
J Neurophysiol, 2021 There is substantial evidence that both N-methyl-D-aspartate receptor (NMDAR) hypofunction and dysfunction of GABAergic neurotransmission contribute to schizophrenia, though the relationship between these pathophysiological processes remains largely ...
Jami SA +5 more
europepmc +2 more sources
Translational neurophysiological biomarkers of N-methyl-d-aspartate receptor dysfunction in serine racemase knockout mice [PDF]
Biomarkers in Neuropsychiatry, 2020 Alterations in glutamatergic function are well established in schizophrenia (Sz), but new treatment development is hampered by the lack of translational pathophysiological and target engagement biomarkers as well as by the lack of animal models that ...
Andrea Balla +4 more
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Regulation of serine racemase activity by d-serine and nitric oxide in human glioblastoma cells
Neuroscience Letters, 2006 In the human glioblastoma cell line U87, the activity of serine racemase (SR), catalyzing the isomerisation of serine, was inversely regulated by D-serine and nitric oxide (NO), a neuromodulator and a neurotransmitter, respectively.
Sofia Mariotto, Hisanori Suzuki
exaly +2 more sources
Serine racemase deletion attenuates neurodegeneration and microvascular damage in diabetic retinopathy. [PDF]
PLoS ONE, 2018 Diabetic retinopathy (DR) is a leading cause of blindness. DR is recognized as a microvascular disease and inner retinal neurodegeneration. In the course of retinal neurodegeneration, N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity is ...
Hironori Ozaki +5 more
doaj +2 more sources
Changes in Serine Racemase-Dependent Modulation of NMDA Receptor: Impact on Physiological and Pathological Brain Aging [PDF]
Frontiers in Molecular Biosciences, 2018 The N-methyl-D-Aspartate glutamate receptors (NMDARs) are pivotal for the functional and morphological plasticity that are required in neuronal networks for efficient brain activities and notably for cognitive-related abilities.
Jean-Marie Billard
doaj +2 more sources
Human serine racemase is nitrosylated at multiple sites
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2018 Serine racemase is a pyridoxal 5'‐phosphate dependent enzyme responsible for the synthesis of d‐serine, a neuromodulator of the NMDA receptors. Its activity is modulated by several ligands, including ATP, divalent cations and protein interactors.
Mozzarelli, Andrea +11 more
core +6 more sources