Serine racemase: a key player in apoptosis and necrosis [PDF]
Frontiers in Synaptic Neuroscience, 2014 A fine balance between cell survival and cell death is required to sculpt the nervous system during development. However, an excess of cell death can occur following trauma, exposure to neurotoxins or alcohol, and some developmental and neurodegenerative
Nadia eCanu +2 more
doaj +7 more sources
D-serine and serine racemase are associated with PSD-95 and glutamatergic synapse stability [PDF]
Frontiers in Cellular Neuroscience, 2016 D-serine is an endogenous coagonist at the glycine site of synaptic NMDA receptors (NMDARs), synthesized by serine racemase (SR) through conversion of L-serine. It is crucial for synaptic plasticity and is implicated in schizophrenia.
Hong eLin +6 more
doaj +4 more sources
Expanding the chemical space of human serine racemase inhibitors
Bioorganic and Medicinal Chemistry Letters, 2015 Serine racemase, the enzyme responsible for D-serine synthesis in the central nervous system, has been identified as a potential therapeutic target to treat N-methyl-D-aspartate receptors-related pathologies.
Luca Dellafiora +2 more
exaly +5 more sources
Localization of serine racemase and its role in the skin. [PDF]
J Invest Dermatol, 2014 D-Serine is an endogenous coagonist of the N-methyl-D-aspartate (NMDA)–type glutamate receptor in the central nervous system and its synthesis is catalyzed by serine racemase (SR).
Inoue R +13 more
europepmc +5 more sources
Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning [PDF]
Biological Psychiatry, 2018 The amygdala is a central component of the neural circuitry that underlies fear learning. N-methyl-D-aspartate receptor-dependent plasticity in the amygdala is required for pavlovian fear conditioning and extinction. N-methyl-D-aspartate receptor activation requires the binding of a coagonist, D-serine, which is synthesized from L-serine by the ...
Darrick T Balu +2 more
exaly +5 more sources
Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease [PDF]
Neurobiology of Disease, 2019 Although β-amyloid plaques are a well-recognized hallmark of Alzheimer's disease (AD) neuropathology, no drugs reducing amyloid burden have shown efficacy in clinical trials, suggesting that once AD symptoms emerge, disease progression becomes ...
Darrick T. Balu +11 more
doaj +2 more sources
D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep [PDF]
Nature Communications, 2019 The physiological function of endogenous D-serine remains a mystery. Here the authors show that endogenous D-serine plays an important role in regulating sleep and that, while the D-serine synthesizing enzyme serine racemase (SR) is expressed both in the
Xihuimin Dai +5 more
doaj +2 more sources
Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function [PDF]
Frontiers in Molecular Biosciences, 2019 Serine racemase (SR) is the first racemase enzyme to be identified in human biology and converts L-serine to D-serine, an important neuronal signaling molecule that serves as a co-agonist of the NMDA (N-methyl-D-aspartate) receptor.
Danielle L. Graham +3 more
doaj +2 more sources
Contribution of serine racemase/d-serine pathway to neuronal apoptosis. [PDF]
Aging Cell, 2012 Recent data indicate that age-related N-methyl-d-aspartate receptor (NMDAR) transmission impairment is correlated with the reduction in serine racemase (SR) expression and d-serine content.
F. Florenzano +23 more
core +9 more sources
Phosphorylation of mouse serine racemase regulates d-serine synthesis
FEBS Letters, 2010 Serine racemase (SR) catalyses the synthesis of the transmitter/neuromodulator d-serine, which plays a major role in synaptic plasticity and N-methyl d-aspartate receptor neurotoxicity.
Foltyn, Veronika N. +6 more
core +4 more sources