Serine Racemase mediates subventricular zone neurogenesis via fatty acid metabolism [PDF]
Stem Cell Reports, 2023 The adult subventricular zone is a neurogenic niche that continuously produce newborn neurons. Here we show that serine racemase (SR), an enzyme that catalyzes the racemization of L-serine to D-serine and vice versa, affects neurogenesis in the adult SVZ
Solomon H. Snyder, Robin Roychaudhuri
exaly +3 more sources
Serine racemase deletion attenuates neurodegeneration and microvascular damage in diabetic retinopathy. [PDF]
PLoS ONE, 2018 Diabetic retinopathy (DR) is a leading cause of blindness. DR is recognized as a microvascular disease and inner retinal neurodegeneration. In the course of retinal neurodegeneration, N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity is ...
Hironori Ozaki +5 more
doaj +3 more sources
D-serine and serine racemase are associated with PSD-95 and glutamatergic synapse stability [PDF]
Frontiers in Cellular Neuroscience, 2016 D-serine is an endogenous coagonist at the glycine site of synaptic NMDA receptors (NMDARs), synthesized by serine racemase (SR) through conversion of L-serine. It is crucial for synaptic plasticity and is implicated in schizophrenia.
Hong eLin +6 more
doaj +5 more sources
Induction of serine racemase expression and
Journal of Neuroinflammation, 2004 Background Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid β-peptide (Aβ), elicit a release of glutamate from microglia. We tested the possibility that a coagonist at the
Griffin W Sue T +5 more
doaj +2 more sources
Contribution of serine racemase/d-serine pathway to neuronal apoptosis. [PDF]
Aging Cell, 2012 Recent data indicate that age-related N-methyl-d-aspartate receptor (NMDAR) transmission impairment is correlated with the reduction in serine racemase (SR) expression and d-serine content.
Borsello T +10 more
core +10 more sources
Phosphorylation of mouse serine racemase regulates d-serine synthesis
FEBS Letters, 2010 Serine racemase (SR) catalyses the synthesis of the transmitter/neuromodulator d-serine, which plays a major role in synaptic plasticity and N-methyl d-aspartate receptor neurotoxicity.
Foltyn, Veronika N. +6 more
core +4 more sources
Journal of Pharmacological Sciences, 2008 Recent studies indicate that an endogenous co-agonist for an N-methyl-D-aspartate (NMDA) receptor–related glycine site, D-serine, is synthesized by serine racemase and is metabolized by D-amino acid oxidase (DAO) and that acute treatment with morphine ...
Masanobu Yoshikawa +7 more
doaj +2 more sources
Serine racemase: a key player in apoptosis and necrosis [PDF]
Frontiers in Synaptic Neuroscience, 2014 A fine balance between cell survival and cell death is required to sculpt the nervous system during development. However, an excess of cell death can occur following trauma, exposure to neurotoxins or alcohol, and some developmental and neurodegenerative
Nadia eCanu +2 more
doaj +5 more sources
Serine racemase binds to PICK1: potential relevance to schizophrenia [PDF]
Molecular Psychiatry, 2006 Accumulating evidence from both genetic and clinico-pharmacological studies suggests that D-serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ).
Sawa, A. +27 more
core +4 more sources
Translational neurophysiological biomarkers of N-methyl-d-aspartate receptor dysfunction in serine racemase knockout mice [PDF]
Biomarkers in Neuropsychiatry, 2020 Alterations in glutamatergic function are well established in schizophrenia (Sz), but new treatment development is hampered by the lack of translational pathophysiological and target engagement biomarkers as well as by the lack of animal models that ...
Andrea Balla +4 more
doaj +2 more sources