Results 41 to 50 of about 4,545 (182)

Reduced d-serine levels drive enhanced non-ionotropic NMDA receptor signaling and destabilization of dendritic spines in a mouse model for studying schizophrenia

Neurobiology of Disease, 2022
Schizophrenia is a psychiatric disorder that affects over 20 million people globally. Notably, schizophrenia is associated with decreased density of dendritic spines and decreased levels of d-serine, a co-agonist required for opening of the N-methyl-d ...
Deborah K. Park, Samuel Petshow, Margarita Anisimova, Eden V. Barragan, John A. Gray, Ivar S. Stein, Karen Zito   +6 more
doaj   +1 more source

Serine racemase is involved in d-aspartate biosynthesis [PDF]

Journal of Biochemistry, 2016
d-Aspartate is found in the nervous and reproductive system and participates in various physiological roles. While several lines of evidence suggest that this amino acid has an endogenous origin, the enzyme responsible for mammalian d-Asp biosynthesis has not yet been identified.
Tomokazu, Ito, Mika, Hayashida, Saki, Kobayashi, Natsumi, Muto, Ayumi, Hayashi, Tohru, Yoshimura, Hisashi, Mori   +6 more
openaire   +2 more sources

Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior.

PLoS ONE, 2013
NMDA receptors are activated after binding of the agonist glutamate to the NR2 subunit along with a co-agonist, either L-glycine or D-serine, to the NR1 subunit.
David-Marian Otte, Maria Luisa Barcena de Arellano, Andras Bilkei-Gorzo, Onder Albayram, Sophie Imbeault, Haang Jeung, Judith Alferink, Andreas Zimmer   +7 more
doaj   +1 more source

Blockade of the N-Methyl-D-Aspartate Glutamate Receptor Ameliorates Lipopolysaccharide-Induced Renal Insufficiency.

PLoS ONE, 2015
N-methyl-D-aspartate (NMDA) receptor activation in rat kidney reduces renal perfusion and ultrafiltration. Hypoperfusion-induced ischemia is the most frequent cause of functional insufficiency in the endotoxemic kidney.
Chian-Shiung Lin, Shun-Fa Hung, Ho-Shiang Huang, Ming-Chieh Ma   +3 more
doaj   +1 more source

Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: Implications for neuropsychiatric diseases

Neurobiology of Disease, 2014
Microdeletion of the human CHRNA7 gene (α7 nicotinic acetylcholine receptor, nAChR) as well as dysfunction in N-methyl-d-aspartate receptors (NMDARs) have been associated with cortical dysfunction in a broad spectrum of neurodevelopmental and ...
Hong Lin, Fu-Chun Hsu, Bailey H. Baumann, Douglas A. Coulter, David R. Lynch   +4 more
doaj   +1 more source

Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL–G–F/NL–G–F mice

Frontiers in Aging Neuroscience, 2023
BackgroundNeurodegenerative processes in Alzheimer’s disease (AD) are associated with excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR). D-Serine is an endogenous co-agonist necessary for NMDAR-mediated excitotoxicity. In the mammalian
Xiance Ni, Xiance Ni, Ran Inoue, Ran Inoue, Yi Wu, Yi Wu, Tomoyuki Yoshida, Tomoyuki Yoshida, Keisuke Yaku, Takashi Nakagawa, Takashi Nakagawa, Takashi Saito, Takashi Saito, Takaomi C. Saido, Keizo Takao, Keizo Takao, Keizo Takao, Hisashi Mori, Hisashi Mori, Hisashi Mori   +19 more
doaj   +1 more source

D-Serine Contributes to Seizure Development via ERK Signaling

Frontiers in Neuroscience, 2019
A seizure is one of the leading neurological disorders. NMDA receptor-mediated neuronal excitation has been thought to be essential for epileptogenesis.
Tie Ma, Tie Ma, Yin Wu, Beibei Chen, Wenjuan Zhang, Lang Jin, Chenxi Shen, Yazhou Wang, Yonghong Liu   +8 more
doaj   +1 more source

d-serine availability modulates prefrontal cortex inhibitory interneuron development and circuit maturation

Scientific Reports, 2023
The proper development and function of telencephalic GABAergic interneurons is critical for maintaining the excitation and inhibition (E/I) balance in cortical circuits.
Oluwarotimi O. Folorunso, Stephanie E. Brown, Jugajyoti Baruah, Theresa L. Harvey, Shekib A. Jami, Inna Radzishevsky, Herman Wolosker, James M. McNally, John A. Gray, Anju Vasudevan, Darrick T. Balu   +10 more
doaj   +1 more source

D-serine in the midbrain periaqueductal gray contributes to morphine tolerance in rats

Molecular Pain, 2016
Background The N-methyl- D -aspartate subtype of glutamate receptor plays a critical role in morphine tolerance. D-serine, a co-agonist of N-methyl- D -aspartate receptor, participates in many physiological and pathophysiological processes via regulating
Song Cao MD, PhD, Zhi Xiao MD, PhD, Mengjie Sun MS, Youyan Li MS   +3 more
doaj   +1 more source

Specific serine racemase immunofluorescence in Srr12 mice.

, 2013
(A) Immunoreactivity for serine racemase is higher in transgenic animals than in Wt controls. Arrows - indicate serine racemase positive cell soma. * - indicates immunoreactivity of the neuropil which is much higher in Srr12 transgenic mice than Wt ...
Haang Jeung (425208), Andras Bilkei-Gorzo (425205), David-Marian Otte (425203), Maria Luisa Barcena de Arellano (425204), Judith Alferink (425209), Önder Albayram (425206), Sophie Imbeault (425207), Andreas Zimmer (78836)   +7 more
core   +1 more source