Results 61 to 70 of about 118,022 (186)

Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: early detection of renal dysfunction using the ratio of serine enantiomers. [PDF]

PLoS ONE, 2014
The imbalance of blood and urine amino acids in renal failure has been studied mostly without chiral separation. Although a few reports have shown the presence of D-serine, an enantiomer of L-serine, in the serum of patients with severe renal failure, it
Jumpei Sasabe, Masataka Suzuki, Yurika Miyoshi, Yosuke Tojo, Chieko Okamura, Sonomi Ito, Ryuichi Konno, Masashi Mita, Kenji Hamase, Sadakazu Aiso   +9 more
doaj   +1 more source

D-serine as a gliotransmitter and its roles in brain development and disease

Frontiers in Cellular Neuroscience, 2013
The development of new techniques to study glial cells has revealed that they are active participants in the development of functional neuronal circuits. Calcium imaging studies demonstrate that glial cells actively sense and respond to neuronal activity.
Marion R Van Horn, Mari eSild, Edward S Ruthazer   +2 more
doaj   +1 more source

Stage‐Dependent Metabolic Reprogramming Drives a Self‐Organizing Microbial Network During Shanxi Aged Vinegar

Food Bioengineering, Volume 5, Issue 3, Page 342-358, September 2026.
Metabolic shifts from growth to stress adaptation in Shanxi aged vinegar fermentation link flavor maturation and microbial cooperation, and Lactobacillus and Acetobacter form a self‐organizing metabolic network through division of labor. ABSTRACT Acetic acid fermentation (AAF) is a vital stage in the production of Shanxi aged vinegar (SAV), during ...
Yanfang Wu, Jing Liu, Dantong Liu, Menglei Xia, Jia Song, Yu Zheng, Min Wang   +6 more
wiley   +1 more source

Regulation of serine racemase activity by d-serine and nitric oxide in human glioblastoma cells.

, 2006
In the human glioblastoma cell line U87, the activity of serine racemase (SR), catalyzing the isomerisation of serine, was inversely regulated by D-serine and nitric oxide (NO), a neuromodulator and a neurotransmitter, respectively.
CIAMPA, Anna Rosa, MARIOTTO, Sofia Giovanna, SHOJI, Kazuo, SUZUKI, Hisanori   +3 more
core   +1 more source

Investigating GERMs: how genotype, environment, and rhizosphere microbiome interactions underlie heat response in maize and sorghum

New Phytologist, Volume 251, Issue 4, Page 2152-2167, August 2026.
Three genotypes – a heat‐resistant maize (Zea mays), a heat‐susceptible maize, and a sorghum (Sorghum bicolor) variety – were grown to the V4 stage in growth chambers under optimal conditions or subjected to heat stress. Plants were grown in soil containing a complex microbial community, or in the same soil with a depleted microbiome.
Nate Korth, Isabella Borrero, Katelyn Rumley, Alex L. Woodley, Mallory J. Choudoir, Joseph L. Gage   +5 more
wiley   +1 more source

Cellular distribution of d-serine, serine racemase and d-amino acid oxidase in the rat vestibular sensory epithelia

, 2006
Glutamate is the main neurotransmitter at the synapses between sensory cells and primary afferents in the peripheral vestibular system. Evidence has recently been obtained demonstrating that the atypical amino acid d-serine is the main endogenous co ...
Mothet, Jean-Pierre, Dememes, D., Nicolas, M.T.   +2 more
core   +1 more source

The role of D-serine and glycine as co-agonists of NMDA receptors in motor neurone degeneration and amyotrophic lateral sclerosis (ALS)

Frontiers in Synaptic Neuroscience, 2014
The fundamental role of D-serine as a co-agonist at the N-methyl-D-aspartate receptor (NMDAR), mediating both physiological actions of glutamate in long term potentiation and nociception and also pathological effects mediated by excitotoxicty, are well ...
Praveen ePaul, Jackie ede Belleroche
doaj   +1 more source

From Prebiotic Catalysts to Modern Applications: How Early Catalysts Inspire Today's Innovations

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
Simple catalytic systems that may have operated under prebiotic conditions offer useful molecular principles for the design of modern functional materials. By examining how amino acids, peptide assemblies, and metal complexes achieve catalysis through simple chemical features, this review highlights how prebiotic chemistry can inspire new strategies ...
Omer Agazani, Meital Reches
wiley   +1 more source

Serine racemase expression and brain D-serine levels in transgenic mice.

, 2013
(A) Schematic representation of the construct for serine racemase overexpression in glial cells under a GFAP promoter. The GFAP promoter is represented as a black line, the serine racemase ORF as a black bar and the SV40 intron/polyA signal as a grey bar.
Haang Jeung (425208), Andras Bilkei-Gorzo (425205), David-Marian Otte (425203), Maria Luisa Barcena de Arellano (425204), Judith Alferink (425209), Önder Albayram (425206), Sophie Imbeault (425207), Andreas Zimmer (78836)   +7 more
core   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source