Results 61 to 70 of about 4,545 (182)

D-serine as a gliotransmitter and its roles in brain development and disease

Frontiers in Cellular Neuroscience, 2013
The development of new techniques to study glial cells has revealed that they are active participants in the development of functional neuronal circuits. Calcium imaging studies demonstrate that glial cells actively sense and respond to neuronal activity.
Marion R Van Horn, Mari eSild, Edward S Ruthazer   +2 more
doaj   +1 more source

Post‐translational regulation of human D‐3‐phosphoglycerate dehydrogenase in Alzheimer's disease

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Emerging evidence suggests that sex‐specific differences in L‐serine (L‐Ser) metabolism play a key role in Alzheimer's disease (AD). While disruptions in amino acid balance are well known, recent findings point to a dimorphic regulation of the serine biosynthetic pathway.
Elena Zerbini, Daniele Riva, Elisa Maffioli, Gabriella Tedeschi, Silvia Sacchi, Loredano Pollegioni   +5 more
wiley   +1 more source

Antinociceptive Effect of Rat D-Serine Racemase Inhibitors, L-Serine-O-Sulfate, and L-Erythro-3-Hydroxyaspartate in an Arthritic Pain Model

The Scientific World Journal, 2012
N-methyl-D-aspartic acid receptor (NMDAr) activation requires the presence of D-serine, synthesized from L-serine by a pyridoxal 5′-phosphate-dependent serine racemase (SR). D-serine levels can be lowered by inhibiting the racemization of L-serine.
Claudio Laurido, Alejandro Hernández, Teresa Pelissier, Luis Constandil   +3 more
doaj   +1 more source

Comparative Genomic and Transcriptomic Analysis Reveals Why Paenarthrobacter Strains Are Specialists in the Degradation of the Fungicide Iprodione

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
Paenarthrobacter are specialists in degrading the fungicide iprodione. We showed that this trait has evolved through gene duplication of ipaH and ddaH genes, being in the core genome of paenarthrobacters, and further genetic optimisation, with different strains being at different evolution stages depending on their prior exposure to iprodione ...
V. Michelioudakis, A. Zafranas, C. Myrisiotis, S. Makri, A. Katsoula, M. Campos, S. Vasileiadis, D. G. Karpouzas   +7 more
wiley   +1 more source

Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: early detection of renal dysfunction using the ratio of serine enantiomers. [PDF]

PLoS ONE, 2014
The imbalance of blood and urine amino acids in renal failure has been studied mostly without chiral separation. Although a few reports have shown the presence of D-serine, an enantiomer of L-serine, in the serum of patients with severe renal failure, it
Jumpei Sasabe, Masataka Suzuki, Yurika Miyoshi, Yosuke Tojo, Chieko Okamura, Sonomi Ito, Ryuichi Konno, Masashi Mita, Kenji Hamase, Sadakazu Aiso   +9 more
doaj   +1 more source

Junctional conductance of retinal AII amacrine cell electrical synapses is decreased by NMDA receptors

The Journal of Physiology, Volume 604, Issue 3, Page 1373-1390, 1 February 2026.
Abstract figure legend AII amacrine cells are an important class of interneuron in the vertebrate retina. In addition to traditional chemical synapses these cells communicate with other neurons and with each other via electrical synapses. (A) Electrical synapse strength between AII amacrine cells was measured using dual whole‐cell patch‐clamp ...
Chloe Cable, Sidney P. Kuo, Eric A. Newman   +2 more
wiley   +1 more source

The role of D-serine and glycine as co-agonists of NMDA receptors in motor neurone degeneration and amyotrophic lateral sclerosis (ALS)

Frontiers in Synaptic Neuroscience, 2014
The fundamental role of D-serine as a co-agonist at the N-methyl-D-aspartate receptor (NMDAR), mediating both physiological actions of glutamate in long term potentiation and nociception and also pathological effects mediated by excitotoxicty, are well ...
Praveen ePaul, Jackie ede Belleroche
doaj   +1 more source

A Nonketotic Hyperglycinemia Mouse Shows Wide‐Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One‐Carbon Charging, and Serine Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Nonketotic hyperglycinemia is a severe neonatal epileptic encephalopathy caused by deficient glycine cleavage enzyme activity, for which currently no effective treatment exists. Incomplete understanding of brain biochemistry represents a major knowledge gap to develop new treatments.
Michael A. Swanson, Hua Jiang, Lakshmi Divya Kolora, Rachel Molino, Richard Reisdorph, Cole R. Michel, Katrina A. Doenges, Kit‐Yi Leung, Xiangping Lin, Frank Wong, Samual Lancaster, Basil Michael, Michael Snyder, Daniella H. Hock, David A. Stroud, Tim Wood, Robert Binard, Laura Anderson‐Lehman, Uwe Christians, Erland Arning, Marisa W. Friederich, Roxanne A. Van Hove, Kenneth N. MacLean, Nicholas D. E. Greene, Johan L. K. Van Hove   +24 more
wiley   +1 more source

Divergent Fates of Hardjo Leptospires: Early Transcriptomic Response of Leptospira interrogans in an Ovine Dialysis Membrane Chamber Model

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Leptospira interrogans serovar Hardjo and Leptospira borgpetersenii serovar Hardjo are major bovine‐ and ovine‐adapted pathogens that differ markedly in genome content. To investigate early events during host exposure, we compared the survival of both species using an ovine peritoneal dialysis membrane chamber (DMC) model, which exposes leptospires to ...
Klaudia Dubniewicz, Laura Pardyak, Patrycja Walczak, Agnieszka Pietsch-Fulbiszewska, Artur Gurgul, Igor Jasielczuk, Tomasz Szmatoła, Zbigniew J. Arent, Yong-guo Cao   +8 more
wiley   +1 more source

Association Study of Serine Racemase Gene with Methamphetamine Psychosis [PDF]

Current Neuropharmacology, 2011
Experimental studies have demonstrated that not only dopaminergic signaling but also glutamatergic/NMDA receptor signaling play indispensable roles in the development of methamphetamine psychosis. Our recent genetic studies provided evidence that genetic variants of glutamate-related genes such as DTNBP1, GLYT1, and G72, which are involved in glutamate
Yokobayashi, E, Ujike, H, Kotaka, T, Okahisa, Y, Takaki, M, Kodama, M, Inada, T, Uchimura, N, Yamada, M, Iwata, N, Iyo, M, Sora, I, Ozaki, N, Kuroda, S   +13 more
openaire   +2 more sources