Results 81 to 90 of about 118,022 (186)

Serine and alanine racemase activities of VanT: A protein necessary for vancomycin resistance in Enterococcus gallinarum BM4174

, 2000
Vancomycin resistance in Enterococcus gallinarum results from the production of UDP-MurNAc-pentapeptide[D-Ser]. VanT, a membrane-bound serine racemase, is one of three proteins essential for this resistance. To investigate the selectivity of racemization
Weisner, Jan, Cesar A. Arias, Arias, Cesar A., Reynolds, Peter E., Peter E. Reynolds, Blackburn, Jonathan M., Jonathan M. Blackburn, Jan Weisner   +7 more
core   +1 more source

Comparative Genomic and Transcriptomic Analysis Reveals Why Paenarthrobacter Strains Are Specialists in the Degradation of the Fungicide Iprodione

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
Paenarthrobacter are specialists in degrading the fungicide iprodione. We showed that this trait has evolved through gene duplication of ipaH and ddaH genes, being in the core genome of paenarthrobacters, and further genetic optimisation, with different strains being at different evolution stages depending on their prior exposure to iprodione ...
V. Michelioudakis, A. Zafranas, C. Myrisiotis, S. Makri, A. Katsoula, M. Campos, S. Vasileiadis, D. G. Karpouzas   +7 more
wiley   +1 more source

Analysis of serine racemase expression in the CNS of epileptic patients [PDF]

, 2010
Serine racemase is a pyridoxal-5'-phosphate dependent enzyme that converts L-serine to D-serine. D-serine is a recognized physiological co-agonist of N-methyl-D-aspartate type of glutamate receptors - key receptors that participate in the ...
Vorlová, Barbora
core  

Human serine racemase is allosterically modulated by NADH and reduced nicotinamide derivatives

, 2016
Serine racemase catalyzes both the synthesis and the degradation of d-serine, an obligatory co-agonist of the glutamatergic NMDA receptors. It is allosterically controlled by adenosine triphosphate (ATP), which increases its activity around 7-fold ...
DELLAFIORA, Luca, CAMPANINI, Barbara, MARCHESANI, FRANCESCO, MOZZARELLI, Andrea, MARGIOTTA, MARILENA, FAGGIANO, Serena, BRUNO, Stefano   +6 more
core   +1 more source

Junctional conductance of retinal AII amacrine cell electrical synapses is decreased by NMDA receptors

The Journal of Physiology, Volume 604, Issue 3, Page 1373-1390, 1 February 2026.
Abstract figure legend AII amacrine cells are an important class of interneuron in the vertebrate retina. In addition to traditional chemical synapses these cells communicate with other neurons and with each other via electrical synapses. (A) Electrical synapse strength between AII amacrine cells was measured using dual whole‐cell patch‐clamp ...
Chloe Cable, Sidney P. Kuo, Eric A. Newman   +2 more
wiley   +1 more source

ATP binding to human serine racemase is cooperative and modulated by glycine

, 2013
The N-methyl D-aspartate (NMDA) receptors play a key role in excitatory neurotransmission, and control learning, memory and synaptic plasticity. Their activity is modulated by the agonist glutamate and by the co-agonists D-serine and glycine.
Nicole Mai, CAMPANINI, Barbara, MARCHETTI, Marialaura, Andrea Mozzarelli, Marialaura Marchetti, Barbara Campanini, MOZZARELLI, Andrea, Mai N, Stefano Bruno, Alessio Peracchi, PERACCHI, Alessio, BRUNO, Stefano   +11 more
core   +1 more source

A Nonketotic Hyperglycinemia Mouse Shows Wide‐Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One‐Carbon Charging, and Serine Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Nonketotic hyperglycinemia is a severe neonatal epileptic encephalopathy caused by deficient glycine cleavage enzyme activity, for which currently no effective treatment exists. Incomplete understanding of brain biochemistry represents a major knowledge gap to develop new treatments.
Michael A. Swanson, Hua Jiang, Lakshmi Divya Kolora, Rachel Molino, Richard Reisdorph, Cole R. Michel, Katrina A. Doenges, Kit‐Yi Leung, Xiangping Lin, Frank Wong, Samual Lancaster, Basil Michael, Michael Snyder, Daniella H. Hock, David A. Stroud, Tim Wood, Robert Binard, Laura Anderson‐Lehman, Uwe Christians, Erland Arning, Marisa W. Friederich, Roxanne A. Van Hove, Kenneth N. MacLean, Nicholas D. E. Greene, Johan L. K. Van Hove   +24 more
wiley   +1 more source

Dysregulation of Plasma Nonessential Amino Acids in Early‐Stage Type 2 Diabetes Mellitus

Journal of Nutrition and Metabolism, Volume 2026, Issue 1, 2026.
Background Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia due to insufficient insulin production or the body’s poor response to insulin (insulin resistance). Amino acids are closely associated with glucose dysregulation, and disturbances of amino acid metabolism may break the balance of muscle breakdown ...
Abdullah Abbas Hamzah Al-Rubaye, Walaa Esmail Jasim, Ahmed A. Mohsin, Nidhi Chaudhary   +3 more
wiley   +1 more source

Divergent Fates of Hardjo Leptospires: Early Transcriptomic Response of Leptospira interrogans in an Ovine Dialysis Membrane Chamber Model

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Leptospira interrogans serovar Hardjo and Leptospira borgpetersenii serovar Hardjo are major bovine‐ and ovine‐adapted pathogens that differ markedly in genome content. To investigate early events during host exposure, we compared the survival of both species using an ovine peritoneal dialysis membrane chamber (DMC) model, which exposes leptospires to ...
Klaudia Dubniewicz, Laura Pardyak, Patrycja Walczak, Agnieszka Pietsch-Fulbiszewska, Artur Gurgul, Igor Jasielczuk, Tomasz Szmatoła, Zbigniew J. Arent, Yong-guo Cao   +8 more
wiley   +1 more source

Glial D-serine modulates oligodendrocyte lineage progression under inflammatory conditions

Frontiers in Cellular Neuroscience
Inflammatory environments may shape oligodendrocyte lineage dynamics beyond classical cytokine signaling, in part through the release of glial neuromodulators.
Juan Pablo Espinoza, Juan Pablo Espinoza, Ignacio Cisterna, Juan Jose Triviño, Verónica Arancibia, Sebastián Beltrán-Castillo   +5 more
doaj   +1 more source