Results 71 to 80 of about 118,022 (186)

D-Amino Acids as a Biomarker in Schizophrenia

Diseases, 2022
D-amino acids may play key roles for specific physiological functions in different organs including the brain. Importantly, D-amino acids have been detected in several neurological disorders such as schizophrenia, amyotrophic lateral sclerosis, and age ...
Kurumi Taniguchi, Haruka Sawamura, Yuka Ikeda, Ai Tsuji, Yasuko Kitagishi, Satoru Matsuda   +5 more
doaj   +1 more source

Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Racemisation, once considered an undesirable synthetic side reaction, also occurs naturally in amino acids and influences biological processes. Evidence links stereochemical conversion to ageing, protein turnover, and cellular development. This review examines mechanisms, control strategies in synthesis, applications and implications in physiology ...
Othman Al Musaimi
wiley   +1 more source

Association Study of Serine Racemase Gene with Methamphetamine Psychosis [PDF]

Current Neuropharmacology, 2011
Experimental studies have demonstrated that not only dopaminergic signaling but also glutamatergic/NMDA receptor signaling play indispensable roles in the development of methamphetamine psychosis. Our recent genetic studies provided evidence that genetic variants of glutamate-related genes such as DTNBP1, GLYT1, and G72, which are involved in glutamate
Yokobayashi, E, Ujike, H, Kotaka, T, Okahisa, Y, Takaki, M, Kodama, M, Inada, T, Uchimura, N, Yamada, M, Iwata, N, Iyo, M, Sora, I, Ozaki, N, Kuroda, S   +13 more
openaire   +2 more sources

D-Serine Metabolism and Its Importance in Development of Dictyostelium discoideum

Frontiers in Microbiology, 2018
In mammals, D-Ser is synthesized by serine racemase (SR) and degraded by D-amino acid oxidase (DAO). D-Ser acts as an endogenous ligand for N-methyl-D-aspartate (NMDA)- and δ2 glutamate receptors, and is involved in brain functions such as learning and ...
Tomokazu Ito, Natsuki Hamauchi, Taisuke Hagi, Naoya Morohashi, Hisashi Hemmi, Yukie G. Sato, Tamao Saito, Tohru Yoshimura   +7 more
doaj   +1 more source

Clonal Stabilization Reveals a DAO/3MST‐Expressing MDCK Subpopulation With Robust d‐Cysteine‐Mediated H2S Production

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
A subpopulation of MDCK (NBL‐2) cells, an epithelial cell line derived from the normal kidney, expresses DAO and 3MST. The DAO/3MST‐expressing cells are progressively eliminated during passaging; however, clonal isolation enables the establishment of sublines that maintain stable H2S production. Clonal cells co‐expressing DAO and 3MST therefore provide
Akari Miyamoto, Haruna Ueno, Hideo Kimura, Tadashi Nakagawa, Norihiro Shibuya   +4 more
wiley   +1 more source

Chronic d-serine supplementation impairs insulin secretion

Molecular Metabolism, 2018
Objective: The metabolic role of d-serine, a non-proteinogenic NMDA receptor co-agonist, is poorly understood. Conversely, inhibition of pancreatic NMDA receptors as well as loss of the d-serine producing enzyme serine racemase have been shown to ...
Lisa Suwandhi, Simone Hausmann, Alexander Braun, Tim Gruber, Silke S. Heinzmann, Eric J.C. Gálvez, Achim Buck, Beata Legutko, Andreas Israel, Annette Feuchtinger, Elizabeth Haythorne, Harald Staiger, Martin Heni, Hans-Ulrich Häring, Philippe Schmitt-Kopplin, Axel Walch, Cristina García Cáceres, Matthias H. Tschöp, Guy A. Rutter, Till Strowig, Martin Elsner, Siegfried Ussar   +21 more
doaj   +1 more source

Artificial Intelligence and Prostate–Breast Cancer Biology: Recent Advances in Treatments and Perspectives — A Comprehensive Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims The therapeutic limitations of conventional cancer treatment currently deployed are driving the development and creation of new nano‐drugs. Prostate cancer (PCa) is a prevalent clinical problem in older men with a significant global incidence, with 1.5 million cases reported in 2022.
Russell B. O. Ouma, Silas M. Ngari, Joshua K. Kibet   +2 more
wiley   +1 more source

d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia.

, 2007
The N-methyl-D-aspartate receptor co-agonist d-serine is synthesized by serine racemase and degraded by D-amino acid oxidase. Both D-serine and its metabolizing enzymes are implicated in N-methyl-D-aspartate receptor hypofunction thought to occur in ...
James N. C. Kew, Louise Verrall, Mary Walker, Nancy Rawlings, Paul J. Harrison, Isabel Benzel, Philip W. J. Burnet   +6 more
core   +1 more source

D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?

Frontiers in Psychiatry, 2019
D-Serine is a potent co-agonist at the NMDA glutamate receptor and has been the object of many preclinical studies to ascertain the nature of its metabolism, its regional and cellular distribution in the brain, its physiological functions and its ...
Mary-Anne B. MacKay, Mary-Anne B. MacKay, Maryana Kravtsenyuk, Maryana Kravtsenyuk, Rejish Thomas, Nicholas D. Mitchell, Nicholas D. Mitchell, Serdar M. Dursun, Serdar M. Dursun, Glen B. Baker, Glen B. Baker   +10 more
doaj   +1 more source

Post‐translational regulation of human D‐3‐phosphoglycerate dehydrogenase in Alzheimer's disease

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Emerging evidence suggests that sex‐specific differences in L‐serine (L‐Ser) metabolism play a key role in Alzheimer's disease (AD). While disruptions in amino acid balance are well known, recent findings point to a dimorphic regulation of the serine biosynthetic pathway.
Elena Zerbini, Daniele Riva, Elisa Maffioli, Gabriella Tedeschi, Silvia Sacchi, Loredano Pollegioni   +5 more
wiley   +1 more source