Results 71 to 80 of about 4,545 (182)

D-Amino Acids as a Biomarker in Schizophrenia

Diseases, 2022
D-amino acids may play key roles for specific physiological functions in different organs including the brain. Importantly, D-amino acids have been detected in several neurological disorders such as schizophrenia, amyotrophic lateral sclerosis, and age ...
Kurumi Taniguchi, Haruka Sawamura, Yuka Ikeda, Ai Tsuji, Yasuko Kitagishi, Satoru Matsuda   +5 more
doaj   +1 more source

Cloning, expression and characterization of human serine racemase mutants [PDF]

, 2010
AAbbssttrraacctt Human serine racemase (hSR) is a cytosolic pyridoxal-5'-phosphate dependent enzyme localized in the central nervous system. It synthesizes D-serine, which is an endogenous coagonist for the N-methyl-D-aspartate (NMDA) receptors and plays
Nováková, Ilona
core  

Glycine Reverses Behavioral Deficits in a Mouse Model for Psychosis With 4 Copies of the Gldc Gene

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
Mice with 4 copies of the glycine decarboxylase (Gldc) gene display startle habituation deficits, which are reversed by treatment with glycine. In control‐treated wild type mice (A), the response to the last startle stimuli is lower than the response to the first startle stimuli. In control‐treated mice with 4 copies of the 9p24.1 genes including Gldc (
Muxiao Wang, Maltesh Kambali, Jinrui Lyu, Rajasekar Nagarajan, Uwe Rudolph   +4 more
wiley   +1 more source

D-Serine Metabolism and Its Importance in Development of Dictyostelium discoideum

Frontiers in Microbiology, 2018
In mammals, D-Ser is synthesized by serine racemase (SR) and degraded by D-amino acid oxidase (DAO). D-Ser acts as an endogenous ligand for N-methyl-D-aspartate (NMDA)- and δ2 glutamate receptors, and is involved in brain functions such as learning and ...
Tomokazu Ito, Natsuki Hamauchi, Taisuke Hagi, Naoya Morohashi, Hisashi Hemmi, Yukie G. Sato, Tamao Saito, Tohru Yoshimura   +7 more
doaj   +1 more source

Identifying sources of D-serine in Caenorhabditis elegans and their impact on behavior

, 2021
Free D-serine (D-Ser) is a potent co-agonist of the N-methyl-D-aspartate receptor (NMDAR) in glutamate neurotransmission and regulates NMDAR functions in the nervous system.
Jonathan V., Sweedler, Nathan E., Schroeder, Nissa J., Larson, Tian A., Qiu, Harvey M., Andersen   +4 more
core   +1 more source

Genomic Analysis for the Safety Assessment of a Potential Probiotic Strain Pediococcus pentosaceus BBS1 Isolated From Lao Fermented Bamboo Shoots (Nor Mai Som)

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Pediococcus pentosaceus BBS1 was analyzed by whole genome sequencing for its classification, annotated its main features for significant genes, and safety characteristics. The strain has the potential to be used as a beneficial probiotic starter culture, improving the quality of the fermented bamboo and related products. ABSTRACT Currently, there is an
Viengvilaiphone Botthoulath, Ida F. Dalmacio, Francisco B. Elegado, Lawrence Yves Uy, Hsiang‐Chun Lin   +4 more
wiley   +1 more source

Chronic d-serine supplementation impairs insulin secretion

Molecular Metabolism, 2018
Objective: The metabolic role of d-serine, a non-proteinogenic NMDA receptor co-agonist, is poorly understood. Conversely, inhibition of pancreatic NMDA receptors as well as loss of the d-serine producing enzyme serine racemase have been shown to ...
Lisa Suwandhi, Simone Hausmann, Alexander Braun, Tim Gruber, Silke S. Heinzmann, Eric J.C. Gálvez, Achim Buck, Beata Legutko, Andreas Israel, Annette Feuchtinger, Elizabeth Haythorne, Harald Staiger, Martin Heni, Hans-Ulrich Häring, Philippe Schmitt-Kopplin, Axel Walch, Cristina García Cáceres, Matthias H. Tschöp, Guy A. Rutter, Till Strowig, Martin Elsner, Siegfried Ussar   +21 more
doaj   +1 more source

Serine and alanine racemase activities of VanT: A protein necessary for vancomycin resistance in Enterococcus gallinarum BM4174

, 2000
Vancomycin resistance in Enterococcus gallinarum results from the production of UDP-MurNAc-pentapeptide[D-Ser]. VanT, a membrane-bound serine racemase, is one of three proteins essential for this resistance. To investigate the selectivity of racemization
Weisner, Jan, Cesar A. Arias, Arias, Cesar A., Reynolds, Peter E., Peter E. Reynolds, Blackburn, Jonathan M., Jonathan M. Blackburn, Jan Weisner   +7 more
core   +1 more source

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study

Epilepsia, Volume 66, Issue 10, Page 3769-3784, October 2025.
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen, Annelii Ny, Daniëlle Copmans, Jana Tits, Kenichi Kamata, Eva Gielis, Kevin Longin, Jo Sourbron, Peravina Thergarajan, Tracie Huey‐Lin Tan, Idrish Ali, Nigel C. Jones, Terence J. O'Brien, Mastura Monif, Bridgette D. Semple, Christine Germeys, Benedetta Frizzi, Virginia Minniti, Sebastian Perrone, Carole L. Linster, Ilaria Elia, Ludo Van Den Bosch, Bruno P. A. Cammue, Arnout Voet, Lieven Lagae, Peter de Witte   +25 more
wiley   +1 more source

D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?

Frontiers in Psychiatry, 2019
D-Serine is a potent co-agonist at the NMDA glutamate receptor and has been the object of many preclinical studies to ascertain the nature of its metabolism, its regional and cellular distribution in the brain, its physiological functions and its ...
Mary-Anne B. MacKay, Mary-Anne B. MacKay, Maryana Kravtsenyuk, Maryana Kravtsenyuk, Rejish Thomas, Nicholas D. Mitchell, Nicholas D. Mitchell, Serdar M. Dursun, Serdar M. Dursun, Glen B. Baker, Glen B. Baker   +10 more
doaj   +1 more source