Results 51 to 60 of about 118,022 (186)
Multienzyme Cascade Reactions: Compatibility, Cooperativity, and Control
Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.Multienzyme cascade reactions are sequences of telescoped biotransformations that avoid the isolation of intermediates and offer significant efficiency advantages over traditional multistep routes. This review article highlights recent examples of multienzyme cascades and explores how their success depends on the consideration of compatibility ...
Isabella E. E. Kroschel +2 more
wiley +1 more source
Hans Journal of Biomedicine, 2013 D-丝氨酸主要存在于哺乳动物的前脑，海马区和纹状体，作为胶质细胞释放的神经递质，作用于NMDA (N-methyl-D-aspartate receptor)受体，引起中枢神经系统中信号的传导。在突触可塑性，学习和记忆等方面起重要作用。丝氨酸消旋酶是一种磷酸吡多醛依赖酶，在ATP和Mg2+的辅助下，通过消旋作用将L型丝氨酸转变为D型丝氨酸。对于神经及精神性疾病，丝氨酸消旋酶可能是一个新的治疗靶点。本文从D-丝氨酸和丝氨酸消旋酶的结构性质，作用机理，功能，调控等方面进行了阐述。 D-serine mainly distributed in the mammalian forebrain, hippocampus and striatum, which as neurotransmit-ters ...
openaire +1 more source
Serine racemase modulation for improving brain insulin resistance
, 2022 This Editorial highlights an interesting study in the current issue of the Journal of Neurochemistry in which Zhou et al. report new data showing that the ablation of serine racemase increases local insulin production in neurons of the hippocampus.
Duarte, João M.N., +3 more
core +2 more sources
D-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology
Neurology Research International, 2012 In mammalian systems, D-serine is perhaps the most biologically active D-amino acid described to date. D-serine is a coagonist at the NMDA-receptor, and receptor activation is dependent on D-serine binding. Because D-serine binding dramatically increases
John P. Crow +2 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2018 Extinction-based exposure therapy is widely used for the treatment of anxiety disorders, such as post-traumatic stress disorder (PTSD). D-serine, an endogenous co-agonist at the glycine-binding site of the N-methyl-D-aspartate-type glutamate receptor ...
Ran Inoue +8 more
doaj +1 more source
Aging Cell, Volume 25, Issue 11, November 2026.This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang +7 more
wiley +1 more source
Cloning, expression and characterization of human serine racemase mutants [PDF]
, 2010 AAbbssttrraacctt Human serine racemase (hSR) is a cytosolic pyridoxal-5'-phosphate dependent enzyme localized in the central nervous system. It synthesizes D-serine, which is an endogenous coagonist for the N-methyl-D-aspartate (NMDA) receptors and plays
Nováková, Ilona
core
Contribution of the D-Serine-dependent pathway to the cellular mechanisms underlying cognitive aging
Frontiers in Aging Neuroscience, 2010 An association between age-related memory impairments and changes in functional plasticity in the aging brain has been under intense study within the last decade.
Emilie Rouaud, Jean-Pierre Mothet
doaj +1 more source
Genomic and Phenotypic Classification of Staphylococcus Species Isolated From Delhi Air
Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.Multiple Staphylococcus spp. were isolated from the outdoor polluted air of the Indian Capital, New Delhi. The bacterial samples were collected from 6 different locations, and the whole genome of four Staphylococcus isolates was sequenced in their entirety. This study presents the comparative genomic analysis of these four isolates.
Himanshu Sen +8 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.ACC astrocytes are morphologically and functionally activated in DCP‐induced chronic itch. Chemogenetic activation of these astrocytes positively modulates the calcium activity of local CaMKII+ excitatory neurons and the release of D‐serine and ATP, and exerts anti‐pruritic, anxiolytic, and anti‐depressant effects.
Ze Fan +12 more
wiley +1 more source