Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase
Frontiers in Molecular Biosciences, 2021 In the central nervous system, the flavoprotein D-amino acid oxidase is responsible for catabolizing D-serine, the main endogenous coagonist of N-methyl-D-aspartate receptor.
Silvia Sacchi +3 more
doaj +1 more source
An Overview of the Involvement of D-Serine in Cognitive Impairment in Normal Aging and Dementia
Frontiers in Psychiatry, 2021 Dementia, of which Alzheimer's disease (AD) is the most common form, is characterized by progressive cognitive deterioration, including profound memory loss, which affects functioning in many aspects of life.
Magdalena Orzylowski +6 more
doaj +1 more source
Impact of Serine Racemase Deletion on Nicotine Discrimination. [PDF]
Nicotine Tob ResAbstract Introduction The high comorbidity between schizophrenia and cigarette smoking points to a possible shared heritable factor predisposing individuals with schizophrenia to nicotine addiction. The N-methyl-d-aspartate (NMDA) receptor has been highly implicated in both schizophrenia and nicotine ...
Yu IL, Coyle JT, Desai RI.
europepmc +3 more sources
Neurobiology of Disease, 2022 Schizophrenia is a psychiatric disorder that affects over 20 million people globally. Notably, schizophrenia is associated with decreased density of dendritic spines and decreased levels of d-serine, a co-agonist required for opening of the N-methyl-d ...
Deborah K. Park +6 more
doaj +1 more source
Identifying sources of D-serine in Caenorhabditis elegans and their impact on behavior [PDF]
, 2021 Free D-serine (D-Ser) is a potent co-agonist of the N-methyl-D-aspartate receptor (NMDAR) in glutamate neurotransmission and regulates NMDAR functions in the nervous system.
Jonathan V., Sweedler +4 more
core +2 more sources
Purification of serine racemase: Biosynthesis of the neuromodulator
Proceedings of the National Academy of Sciences, 1999 High levels of d -serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N -methyl- d -aspartate receptors. In glial cultures of rat cerebral cortex,
H, Wolosker +6 more
openaire +2 more sources
Evolution and Functional Diversification of Serine Racemase Homologs in Bacteria. [PDF]
J Mol EvolAmino acid racemases catalyze the interconversion of L- and D-amino acids, maintaining intracellular levels of both D- and L-amino acids. While alanine and glutamate racemases are widespread in bacteria, serine racemase (SerR) is predominantly found in animals.
Uda K +5 more
europepmc +3 more sources
Conformational flexibility within the small domain of human serine racemase. [PDF]
Acta Crystallogr F Struct Biol Commun, 2020 Serine racemase (SR) is a pyridoxal 5′-phosphate (PLP)-containing enzyme that converts L-serine to D-serine, an endogenous co-agonist for the N-methyl-D-aspartate receptor (NMDAR) subtype of glutamate ion channels.
Koulouris CR, Bax BD, Atack JR, Roe SM.
europepmc +2 more sources
Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior.
PLoS ONE, 2013 NMDA receptors are activated after binding of the agonist glutamate to the NR2 subunit along with a co-agonist, either L-glycine or D-serine, to the NR1 subunit.
David-Marian Otte +7 more
doaj +1 more source
The Role of Serine Racemase in the Pathophysiology of Brain Disorders. [PDF]
Adv Pharmacol, 2018 The N-methyl-d-aspartate receptor (NMDAR) is unique in requiring two agonists to bind simultaneously to open its cation channel: the neurotransmitter, glutamate, and the coagonists, glycine, or d-serine. The Snyder laboratory was the first to clone serine racemase (SR), the enzyme that synthesizes d-serine, and to localize it immunocytochemically.
Coyle JT, Balu DT.
europepmc +4 more sources