Results 31 to 40 of about 4,545 (182)

Serine racemase: a key player in neuron activity and in neuropathologies

Frontiers in Bioscience, 2013
Serine racemase is the pyridoxal 5’-phosphatedependent enzyme that catalyzes L-serine racemisation to D-serine, and L- and D-serine beta-elimination in mammalian brain.
CAMPANINI, Barbara, SPYRAKIS, Francesca, MOZZARELLI, Andrea, PERACCHI, Alessio   +3 more
core   +5 more sources

Serine Racemase Expression by Striatal Neurons. [PDF]

Cell Mol Neurobiol, 2022
D-serine is synthesized by serine racemase (SR) and is a co-agonist at forebrain N-methyl-D-aspartate receptors (NMDARs). D-serine and SR are expressed primarily in neurons, but not in quiescent astrocytes. In this study, we examined the localization of D-serine and SR in the mouse striatum and the effects of genetically silencing SR expression in ...
Takagi S, Puhl MD, Anderson T, Balu DT, Coyle JT.   +4 more
europepmc   +3 more sources

Serine racemase binds to PICK1: potential relevance to schizophrenia [PDF]

Molecular Psychiatry, 2006
Accumulating evidence from both genetic and clinico-pharmacological studies suggests that D-serine, an endogenous coagonist to the NMDA subtype glutamate receptor, may be implicated in schizophrenia (SZ).
Sawa, A., T Hikida, Mustafa, A. K., Fujii, K., Okawa, M., Huganir, R. L., Balkissoon, R., T Yamada, Ujike, H., Snyder, S. H., R Kawahara, Kawahara, R., R Balkissoon, S H Snyder, Hikida, T., K Maeda, A Sawa, Yamada, T., Y Ozeki, R L Huganir, Maeda, K., H Ujike, Xia, J., Ozeki, Y., J Xia, K Fujii, M Okawa, A K Mustafa   +27 more
core   +4 more sources

Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase

Frontiers in Molecular Biosciences, 2021
In the central nervous system, the flavoprotein D-amino acid oxidase is responsible for catabolizing D-serine, the main endogenous coagonist of N-methyl-D-aspartate receptor.
Silvia Sacchi, Valentina Rabattoni, Matteo Miceli, Loredano Pollegioni   +3 more
doaj   +1 more source

An Overview of the Involvement of D-Serine in Cognitive Impairment in Normal Aging and Dementia

Frontiers in Psychiatry, 2021
Dementia, of which Alzheimer's disease (AD) is the most common form, is characterized by progressive cognitive deterioration, including profound memory loss, which affects functioning in many aspects of life.
Magdalena Orzylowski, Magdalena Orzylowski, Esther Fujiwara, Esther Fujiwara, Darrell D. Mousseau, Glen B. Baker, Glen B. Baker   +6 more
doaj   +1 more source

Forebrain expression of serine racemase during postnatal development. [PDF]

Neurochem Int, 2021
N-methyl-D-aspartate receptors (NMDARs) are important for synaptogenesis, synaptic maturation and refinement during the early postnatal weeks after birth. Defective synapse formation or refinement underlie cognitive and emotional abnormalities in various neurodevelopmental disorders (NDDs), including schizophrenia (Sz) and autism spectrum disorder (ASD)
Folorunso OO, Harvey TL, Brown SE, Cruz C, Shahbo E, Ajjawi I, Balu DT.   +6 more
europepmc   +3 more sources

Impact of Serine Racemase Deletion on Nicotine Discrimination. [PDF]

Nicotine Tob Res
Abstract Introduction The high comorbidity between schizophrenia and cigarette smoking points to a possible shared heritable factor predisposing individuals with schizophrenia to nicotine addiction. The N-methyl-d-aspartate (NMDA) receptor has been highly implicated in both schizophrenia and nicotine ...
Yu IL, Coyle JT, Desai RI.
europepmc   +3 more sources

Evolution and Functional Diversification of Serine Racemase Homologs in Bacteria. [PDF]

J Mol Evol
Amino acid racemases catalyze the interconversion of L- and D-amino acids, maintaining intracellular levels of both D- and L-amino acids. While alanine and glutamate racemases are widespread in bacteria, serine racemase (SerR) is predominantly found in animals.
Uda K, Nishimura R, Li Y, Shimoda E, Miyamoto T, Moe LA.   +5 more
europepmc   +3 more sources

Purification of serine racemase: Biosynthesis of the neuromodulator d -serine [PDF]

Proceedings of the National Academy of Sciences, 1999
High levels of d -serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N -methyl- d -aspartate receptors. In glial cultures of rat cerebral cortex, d -serine is enriched in type II astrocytes and is
H, Wolosker, K N, Sheth, M, Takahashi, J P, Mothet, R O, Brady, C D, Ferris, S H, Snyder   +6 more
openaire   +2 more sources

The Role of Serine Racemase in the Pathophysiology of Brain Disorders. [PDF]

Adv Pharmacol, 2018
The N-methyl-d-aspartate receptor (NMDAR) is unique in requiring two agonists to bind simultaneously to open its cation channel: the neurotransmitter, glutamate, and the coagonists, glycine, or d-serine. The Snyder laboratory was the first to clone serine racemase (SR), the enzyme that synthesizes d-serine, and to localize it immunocytochemically.
Coyle JT, Balu DT.
europepmc   +4 more sources