Results 91 to 100 of about 118,022 (186)
Glycine Reverses Behavioral Deficits in a Mouse Model for Psychosis With 4 Copies of the Gldc Gene
Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.Mice with 4 copies of the glycine decarboxylase (Gldc) gene display startle habituation deficits, which are reversed by treatment with glycine. In control‐treated wild type mice (A), the response to the last startle stimuli is lower than the response to the first startle stimuli. In control‐treated mice with 4 copies of the 9p24.1 genes including Gldc (
Muxiao Wang +4 more
wiley +1 more source
Fabrication and use of D-serine biosensors for characterising D-serine signalling in rat brain [PDF]
D-serine is a co-agonist at NMDA receptors in the brain but the study of this amino acid is restricted by current techniques. I have designed highly sensitive D-serine biosensors that permit accurate real-time recordings of D-serine in the brain in a ...
Bibi, Shakila
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Clinical and biochemical study of D-serine metabolism among schizophrenia patients
Neuropsychiatric Disease and Treatment, 2017 Hamdy N El-Tallawy,1 Tahia H Saleem,2 Abdallah MAA El-Ebidi,3 Mohammed H Hassan,4 Romany H Gabra,1 Wafaa MA Farghaly,1 Nagwa Abo El-Maali,5 Hoda S Sherkawy3 1Department of Neuropsychiatry, 2Department of Medical Biochemistry and Molecular Biology ...
El-Tallawy HN +7 more
doaj
Mammalian Serine Racemase as a Pharmaceutical Terget
, 2010 PH.D. DISSERTATION Mammalian Serine Racemase as a Pharmaceutical Target Jana Jirásková Supervisor: Jan Konvalinka Department of Biochemistry Faculty of Science Charles University Institute of Organic Chemistry and Biochemistry Gilead Sciences & IOCB ...
Vaníčková, Jana
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Inhibitors of mouse serine racemase
, 2019 Serine racemase (SR) is a pyridoxal-5'-phosphate-dependent enzyme responsible for biosynthesis of D-serine, a recognized neurotransmitter acting as a co-activator of N-methyl- D-aspartate (NMDA) type of glutamate receptors in the mammalian central ...
Vorlová, Barbora
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Frontiers in Pharmacology, 2019 Research indicates that neurosteroids are locally synthesized in the central nervous system and play an important modulatory role in nociception. While the neurosteroidogenic enzyme, cytochrome P450 side-chain cleavage enzyme (P450scc), is the initiating
Sheu-Ran Choi +2 more
doaj +1 more source
Inhibitors of mouse serine racemase
, 2013 Serine racemase (SR) is a pyridoxal-5'-phosphate-dependent enzyme responsible for biosynthesis of D-serine, a recognized neurotransmitter acting as a co-activator of N-methyl- D-aspartate (NMDA) type of glutamate receptors in the mammalian central ...
Vorlová, Barbora
core
, 2017 The results of a qualitative and quantitative analysis of serine racemase expression in the hippocampus of rats in chronic cerebral blood-flow disorders modeled by hypergravity in the caudo-cranial vector are presented in this article.
M. V. Schmidt +6 more
core +1 more source
Peripheral Biomarker for Vascular Disorders
Biomarker Insights, 2018 Atherosclerosis is the underlying cause of most myocardial infarction (MI) and ischaemic stroke episodes. An early sign of atherosclerosis is hypertrophy of the arterial wall.
Kaneez Fatima Shad +3 more
doaj +1 more source
Journal of Neuroinflammation, 2011 Background Recent data indicate that inflammatory mechanisms contribute to diabetic retinopathy (DR). We have determined that serine racemase (SR) expression is increased by inflammatory stimuli including liposaccharide (LPS), amyloid β-peptide (A-beta),
Yin Guibin +7 more
doaj +1 more source