Results 91 to 100 of about 4,545 (182)
Journal of Neurochemistry, Volume 169, Issue 9, September 2025.Duchenne muscular dystrophy (DMD) is frequently associated with neurobehavioral and cognitive impairments, including psychiatric symptoms, resulting from the absence of full‐length dystrophin, alone or in combination with its shorter isoforms. This study provides new insights into how dystrophin deficiency may interfere with neurophysiological ...
Francesca Mastrostefano +6 more
wiley +1 more source
ATP binding to human serine racemase is cooperative and modulated by glycine
, 2013 The N-methyl D-aspartate (NMDA) receptors play a key role in excitatory neurotransmission, and control learning, memory and synaptic plasticity. Their activity is modulated by the agonist glutamate and by the co-agonists D-serine and glycine.
Nicole Mai +11 more
core +1 more source
The Landscape of Cancer Metabolism as a Therapeutic Target
Pathology International, Volume 75, Issue 8, Page 387-402, August 2025.ABSTRACT Cancer cells reprogram their metabolism during progression to adapt to the tumor microenvironment, which is characterized by distinct differences in nutrient availability, oxygen concentrations, and acidity. This metabolic reprogramming can simultaneously create metabolic vulnerabilities unique to cancer cells, making cancer metabolism a ...
Kenji Ohshima
wiley +1 more source
Glial D-serine modulates oligodendrocyte lineage progression under inflammatory conditions
Frontiers in Cellular NeuroscienceInflammatory environments may shape oligodendrocyte lineage dynamics beyond classical cytokine signaling, in part through the release of glial neuromodulators.
Juan Pablo Espinoza +5 more
doaj +1 more source
Inhibitors of mouse serine racemase
, 2013 Serine racemase (SR) is a pyridoxal-5'-phosphate-dependent enzyme responsible for biosynthesis of D-serine, a recognized neurotransmitter acting as a co-activator of N-methyl- D-aspartate (NMDA) type of glutamate receptors in the mammalian central ...
Vorlová, Barbora
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Mammalian Tolerance to Amino Acid Heterochirality
ChemBioChem, Volume 26, Issue 13, July 11, 2025.Organisms preferentially use l‐amino acids (l‐AAs). However, de novo synthesized l‐AAs are in part converted to d‐AAs. The ribosome has a robust system to use l‐AAs for protein synthesis, whereas non‐ribosomal synthesis can also use d‐AAs. Furthermore, some AA residues can be post‐translationally isomerized through enzymatic or spontaneous processes ...
Sakiko Taniguchi +4 more
wiley +1 more source
Inhibitors of mouse serine racemase
, 2019 Serine racemase (SR) is a pyridoxal-5'-phosphate-dependent enzyme responsible for biosynthesis of D-serine, a recognized neurotransmitter acting as a co-activator of N-methyl- D-aspartate (NMDA) type of glutamate receptors in the mammalian central ...
Vorlová, Barbora
core
Clinical and biochemical study of D-serine metabolism among schizophrenia patients
Neuropsychiatric Disease and Treatment, 2017 Hamdy N El-Tallawy,1 Tahia H Saleem,2 Abdallah MAA El-Ebidi,3 Mohammed H Hassan,4 Romany H Gabra,1 Wafaa MA Farghaly,1 Nagwa Abo El-Maali,5 Hoda S Sherkawy3 1Department of Neuropsychiatry, 2Department of Medical Biochemistry and Molecular Biology ...
El-Tallawy HN +7 more
doaj
, 2017 The results of a qualitative and quantitative analysis of serine racemase expression in the hippocampus of rats in chronic cerebral blood-flow disorders modeled by hypergravity in the caudo-cranial vector are presented in this article.
M. V. Schmidt +6 more
core +1 more source
Mammalian Serine Racemase as a Pharmaceutical Terget
, 2010 PH.D. DISSERTATION Mammalian Serine Racemase as a Pharmaceutical Target Jana Jirásková Supervisor: Jan Konvalinka Department of Biochemistry Faculty of Science Charles University Institute of Organic Chemistry and Biochemistry Gilead Sciences & IOCB ...
Vaníčková, Jana
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