Results 111 to 120 of about 4,545 (182)

The D-serine biosynthetic enzyme serine racemase is expressed by reactive astrocytes in the amygdala of human and a mouse model of Alzheimer's disease. [PDF]

Neurosci Lett, 2023
Folorunso OO, Harvey TL, Brown SE, Chelini G, Berretta S, Balu DT.   +5 more
europepmc   +1 more source

Human Serine Racemase Weakly Binds the Third PDZ Domain of PSD-95. [PDF]

Int J Mol Sci, 2022
Giaccari R, Marchesani F, Compari C, Fisicaro E, Mozzarelli A, Campanini B, Bettati S, Bruno S, Faggiano S.   +8 more
europepmc   +1 more source

Viral vector-mediated upregulation of serine racemase expression in medial prefrontal cortex improves learning and synaptic function in middle age rats. [PDF]

Aging (Albany NY), 2023
Yegla B, Rani A, Kumar A.
europepmc   +1 more source

The role of DAAO in cognitive impairment of offspring mice induced by arsenic exposure during early developmental stage.

PLoS ONE
Arsenic exposure model of offspring mice was established and intervened with 6-chlorobenzo[d]isoxazol-3-ol (CBIO), a D-amino acid oxidase (DAAO) inhibitor, to explore the role of DAAO in cognitive impairment of offspring mice induced by arsenic during ...
Zehua Niu, Xiao Xie, Xiaoxia Jin, Haiyang Yu, Ge Jin, Yan Wang   +5 more
doaj   +1 more source

Characterization of recombinant human serine racemase

, 2010
6 Brief Abstract The pyridoxal-5'-phosphate-dependent enzyme serine racemase (SR) is responsible for the biosynthesis of D-serine in the mammalian central nervous system.
Hoffman, Hillary Elizabeth
core   +1 more source

A New Three-Hit Mouse Model of Neurodevelopmental Disorder with Cognitive Impairments and Persistent Sociability Deficits

Brain Sciences
Background/Objectives: Cognitive deficits and negative symptoms associated with schizophrenia are poorly managed by current antipsychotics. In order to develop effective treatments, refining animal models of neurodevelopmental disorders is essential ...
Imane Mouffok, Caroline Lahogue, Thomas Cailly, Thomas Freret, Valentine Bouet, Michel Boulouard   +5 more
doaj   +1 more source

Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum. [PDF]

Brain Res, 2021
Takagi S, Balu DT, Coyle JT.
europepmc   +1 more source

Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target

, 2016
d-Serine is the co-agonist of NMDA receptors and binds to the so-called glycine site. d-Serine is synthesized by human serine racemase (SR). Over activation of NMDA receptors is involved in many neurodegenerative diseases and, therefore, the inhibition ...
COSTANTINO, Gabriele, PIERONI, Marco, BEATO, Claudia, CAMPANINI, Barbara, MARCHETTI, Marialaura, MOZZARELLI, Andrea, PECCHINI, Chiara, Cocconcelli, Chiara   +7 more
core   +1 more source

Commentary on Urinary l-erythro-β-hydroxyasparagine: a novel serine racemase inhibitor and substrate of the Zn2+-dependent d-serine dehydratase. [PDF]

Biosci Rep, 2021
Tamaki FK.
europepmc   +1 more source

Switching the function of PLP-dependent human serine racemase to serine dehydratase and vice versa by point mutation

, 2013
絲胺酸消旋酶主要功能是產生D-絲胺酸，D-絲胺酸是在腦部中的N-甲基,D-天門冬胺受體 (NMDARs)之共促效劑 (co-agonist)，哺乳類動物的絲胺酸消旋酶可將L 及D-絲胺酸互相轉換，也可將L 及D-絲胺酸脫水轉變成丙酮酸。我們觀察到絲胺酸消旋酶和人體中另一個酵素絲胺酸脫水酶在蛋白質序列上只有23 %的相似性但結構上相似度很高，但絲胺酸脫水酶卻只有一種將L-絲胺酸轉變成丙酮酸的功能。它們之間的關係引發了我們高度興趣。在蛋白質序列比對分析中,指出在絲胺酸消旋酶催化活性中心的第84 ...
王瓊儀, Wang, Cyong-Yi
core