Results 121 to 130 of about 118,022 (186)

Serine racemase (SRR) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Catalytic Plasticity of the Aspartate/Glutamate Racemase Superfamily [PDF]

, 2009
The bacterial and archaeal Asp/Glu racemase enzyme superfamily contains a variety of catalytic functions that have great potential for use in industrial biocatalysis.
Fisch, Florian A
core  

Information-Rich, Dual-Function ¹³C/²H-Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme "Partitioning Fingerprint" and Reveals Disparate Chemotypes for hSR Inhibition. [PDF]

J Am Chem Soc, 2023
Ramos de Dios SM, Hass JL, Graham DL, Kumar N, Antony AE, Morton MD, Berkowitz DB.   +6 more
europepmc   +1 more source

Switching the function of PLP-dependent human serine racemase to serine dehydratase and vice versa by point mutation

, 2013
絲胺酸消旋酶主要功能是產生D-絲胺酸，D-絲胺酸是在腦部中的N-甲基,D-天門冬胺受體 (NMDARs)之共促效劑 (co-agonist)，哺乳類動物的絲胺酸消旋酶可將L 及D-絲胺酸互相轉換，也可將L 及D-絲胺酸脫水轉變成丙酮酸。我們觀察到絲胺酸消旋酶和人體中另一個酵素絲胺酸脫水酶在蛋白質序列上只有23 %的相似性但結構上相似度很高，但絲胺酸脫水酶卻只有一種將L-絲胺酸轉變成丙酮酸的功能。它們之間的關係引發了我們高度興趣。在蛋白質序列比對分析中,指出在絲胺酸消旋酶催化活性中心的第84 ...
王瓊儀, Wang, Cyong-Yi
core  

Urinary l-erythro-β-hydroxyasparagine-a novel serine racemase inhibitor and substrate of the Zn2+-dependent d-serine dehydratase. [PDF]

Biosci Rep, 2021
Ito T, Tono M, Kitaura Y, Hemmi H, Yoshimura T.   +4 more
europepmc   +1 more source

Blood levels of D-aspartate oxidase, D-amino acid oxidase, serine racemase, and pLG72 are influenced by diagnoses of schizophrenia and autism spectrum disorder. [PDF]

Schizophrenia (Heidelb)
Maffioli E, Errico F, Motta Z, di Vito R, Grana J, De Grandis E, Boeri S, Bruno C, Riccio MP, Iasevoli F, Di Maio M, Nuzzo T, Bravaccio C, Bagnasco S, Gelzo M, Castaldo G, de Bartolomeis A, Negri A, Pollegioni L, Tedeschi G, Usiello A.   +20 more
europepmc   +1 more source

Microglial serine racemase knockout alleviates Alzheimer-like neuropathology and behavioral deficit via lactylation-mediated anti-inflammation. [PDF]

Commun Biol
Zhou J, Yang Y, Liu S, Chen J, Liao H, Liang W, Zhang Z, Wang Y, Liu Y, Zhang H, Jiang H, Lin W, Qu J, Barger SW, Wu S.   +14 more
europepmc   +1 more source

Serine Racemase Deletion Affects the Excitatory/Inhibitory Balance of the Hippocampal CA1 Network. [PDF]

Int J Mol Sci, 2020
Ploux E, Bouet V, Radzishevsky I, Wolosker H, Freret T, Billard JM.   +5 more
europepmc   +1 more source

Accelerated identification of serine racemase inhibitor from Centella asiatica. [PDF]

Sci Rep, 2020
Rani K, Tyagi M, Mazumder M, Singh A, Shanmugam A, Dalal K, Pillai M, Samudrala G, Kumar S, Srinivasan A.   +9 more
europepmc   +1 more source

Corrigendum: D-serine contributes to seizure development via ERK signaling

Frontiers in Neuroscience
Tie Ma, Tie Ma, Yin Wu, Beibei Chen, Wenjuan Zhang, Lang Jin, Chenxi Shen, Yazhou Wang, Yonghong Liu   +8 more
doaj   +1 more source