, 2018 d-Serine is the co-agonist of NMDA receptors and binds to the so-called glycine site. d-Serine is synthesized by human serine racemase (SR). Over activation of NMDA receptors is involved in many neurodegenerative diseases and, therefore, the inhibition ...
Chiara Cocconcelli (2627434) +7 more
core +1 more source
Information-Rich, Dual-Function 13C/2H-Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme "Partitioning Fingerprint" and Reveals Disparate Chemotypes for hSR Inhibition. [PDF]
J Am Chem Soc, 2023 Ramos de Dios SM +6 more
europepmc +1 more source
Urinary l-erythro-β-hydroxyasparagine-a novel serine racemase inhibitor and substrate of the Zn2+-dependent d-serine dehydratase. [PDF]
Biosci Rep, 2021 Ito T +4 more
europepmc +1 more source
, 2016 An alcohol dehydrogenase from Clostridium acetobutylicum (CaADH) recently reported by our lab and deployed in the stereoselective reduction of β-ketoesters to medicinally relevant chiral synthons, has now been applied to the reduction of α,α- difluoro-β ...
Applegate, Gregory A
core
Serine Racemase Deletion Affects the Excitatory/Inhibitory Balance of the Hippocampal CA1 Network. [PDF]
Int J Mol Sci, 2020 Ploux E +5 more
europepmc +1 more source
Microglial serine racemase knockout alleviates Alzheimer-like neuropathology and behavioral deficit via lactylation-mediated anti-inflammation. [PDF]
Commun BiolZhou J +14 more
europepmc +1 more source
Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson's disease?
Neural Regen Res, 2021 Nickels SL, Schwamborn JC.
europepmc +1 more source
Nuclear Compartmentalization of Serine Racemase Regulates d-Serine Production [PDF]
Journal of Biological Chemistry, 2015 Goren Kolodney +6 more
openaire +1 more source
Accelerated identification of serine racemase inhibitor from Centella asiatica. [PDF]
Sci Rep, 2020 Rani K +9 more
europepmc +1 more source