Results 141 to 150 of about 118,022 (186)

A Novel PLP-Dependent Alanine/Serine Racemase From the Hyperthermophilic Archaeon Pyrococcus horikoshii OT-3. [PDF]

Front Microbiol, 2018
Kawakami R, Ohshida T, Sakuraba H, Ohshima T.   +3 more
europepmc   +1 more source

Crystal structure of maize serine racemase with pyridoxal 5'-phosphate. [PDF]

Acta Crystallogr F Struct Biol Commun, 2016
Zou L, Song Y, Wang C, Sun J, Wang L, Cheng B, Fan J.   +6 more
europepmc   +1 more source

Serine racemase is expressed in islets and contributes to the regulation of glucose homeostasis. [PDF]

Islets, 2016
Lockridge AD, Baumann DC, Akhaphong B, Abrenica A, Miller RF, Alejandro EU.   +5 more
europepmc   +1 more source

Altered CREB Binding to Activity-Dependent Genes in Serine Racemase Deficient Mice, a Mouse Model of Schizophrenia. [PDF]

ACS Chem Neurosci, 2018
Balu DT, Coyle JT.
europepmc   +1 more source

Structure and function of serine racemase

Structure and function of serine racemase
openaire   +1 more source

Expanding the chemical space of human serine racemase inhibitors

Bioorganic and Medicinal Chemistry Letters, 2015
Serine racemase, the enzyme responsible for D-serine synthesis in the central nervous system, has been identified as a potential therapeutic target to treat N-methyl-D-aspartate receptors-related pathologies.
Luca Dellafiora, Francesca Spyrakis, Gabriele Cruciani   +2 more
exaly   +5 more sources

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Mechanism of eukaryotic serine racemase-catalyzed serine dehydration

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2020
Eukaryotic serine racemase (SR) is a pyridoxal 5'-phosphate enzyme belonging to the Fold-type II group, which catalyzes serine racemization and is responsible for the synthesis of D-Ser, a co-agonist of the N-methyl-d-aspartate receptor. In addition to racemization, SR catalyzes the dehydration of D- and L-Ser to pyruvate and ammonia.
Soichiro Watanabe, Tomokazu Ito, Masaru Goto   +2 more
exaly   +3 more sources

The Structure of Mammalian Serine Racemase [PDF]

Journal of Biological Chemistry, 2010
Isabel Moraes, John Barker
exaly   +2 more sources

Serine racemase and the serine shuttle between neurons and astrocytes

Biochimica Et Biophysica Acta - Proteins and Proteomics, 2011
d-Serine is a brain-enriched d-amino acid that works as a transmitter-like molecule by physiologically activating NMDA receptors. Synthesis of d-serine is carried out by serine racemase (SR), a pyridoxal 5'-phosphate-dependent enzyme. In addition to carry out racemization, SR α,β-eliminates water from l- or d-serine, generating pyruvate and NH(4 ...
Herman Wolosker
exaly   +3 more sources

Characterization and localization of a human serine racemase

Molecular Brain Research, 2004
D-serine is present in the mammalian central nervous system, where it acts as one of the co-activators of N-methyl-D aspartate receptors. Synthesis of D-serine is catalyzed by the serine racemase enzyme. The current studies report on the isolation of a cDNA encoding a human serine racemase (SRR) from the human neuronal like cell line, NT2N.
Menghang, Xia, Yuan, Liu, David J, Figueroa, Chi-Sung, Chiu, Nan, Wei, Ann-Marie, Lawlor, Ping, Lu, Cyrille, Sur, Ken S, Koblan, Thomas M, Connolly   +9 more
openaire   +2 more sources