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Distribution and evolution of the serine/aspartate racemase family in invertebrates
Amino Acids, 2015Free D-amino acids have been found in various invertebrate phyla, while amino acid racemase genes have been identified in few species. The purpose of this study is to elucidate the distribution, function, and evolution of amino acid racemases in invertebrate animals.
Kouji, Uda +8 more
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Inhibition of serine and proline racemases by substrate-product analogues
Bioorganic & Medicinal Chemistry Letters, 2014d-Amino acids can play important roles as specific biosynthetic building blocks required by organisms or act as regulatory molecules. Consequently, amino acid racemases that catalyze the formation of d-amino acids are potential therapeutic targets. Serine racemase catalyzes the reversible formation of d-serine (a modulator of neurotransmission) from l ...
Matthew Harty +5 more
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Novel role of serine racemase in anti-apoptosis and metabolism
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017Serine racemase (SR) catalyzes the production of d-serine, a co-agonist of the N-methyl-d-aspartate receptor (NMDAR). A previous report shows the contribution of SR in the NMDAR-mediated neuronal cell death process.To analyze the intrinsic role of SR in the cell death process, we established the epithelial human embryonic kidney 293T (HEK293T) cell ...
Gourango, Talukdar +6 more
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Distribution and evolution of the serine/aspartate racemase family in plants
Phytochemistry, 2020Atanas Radkov +2 more
exaly
D-serine and serine racemase in the retina.
2011S. B. Smith, Y. Ha, V. Ganapathy
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Human serine racemase: moleular cloning, genomic organization and functional analysis
Gene, 2000Herman Wolosker +2 more
exaly