Results 101 to 110 of about 118,022 (186)
Identification of genes involved in osteoblast differentiation with an shRNA-based approach [PDF]
, 2009 Mesenchymal stem cells (MSCs) derived from bone marrow and they can differentiate in a variety of cell types, including osteoblasts, adipocytes, chondrocytes, myoblasts, hepatocytes, and neural cells.
Cozzolino, Carmine
core +1 more source
Metabolism of the neuromodulator D-serine
, 2010 Over the past years, accumulating evidence has indicated that d-serine is the endogenous ligand for the glycine-modulatory binding site on the NR1 subunit of N-methyl-d-aspartate receptors in various brain areas.
POLLEGIONI, LOREDANO, SACCHI, SILVIA
core +1 more source
, 2010 D-serine is an endogenous N-methyl-D-aspartate (NMDA) receptor coagonist. It is synthesized from L-serine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active D-amino acid oxidase ...
Wood, Matthew J. A., +5 more
core +2 more sources
Structural and Functional Adaptation of Vancomycin Resistance VanT Serine Racemases
mBio, 2015 Vancomycin resistance in Gram-positive bacteria results from the replacement of the d-alanyl–d-alanine target of peptidoglycan precursors with d-alanyl–d-lactate or d-alanyl–d-serine (d-Ala-d-Ser), to which vancomycin has low binding affinity.
Djalal Meziane-Cherif +5 more
doaj +1 more source
NeurotherapeuticsTrimethylamine N-oxide (TMAO), a co-metabolite of the gut microbiota and host, has been implicated in the pathogenesis of various neuropsychiatric disorders. However, its role in major depressive disorder (MDD) remains poorly understood.
Liwang Lin +12 more
doaj +1 more source
Molecular Pain, 2019 Spinal D-serine plays an important role in nociception via an increase in phosphorylation of the N -Methyl-D-aspartate (NMDA) receptor GluN1 subunit (pGluN1). However, the cellular mechanisms underlying this process have not been elucidated.
Sheu-Ran Choi +7 more
doaj +1 more source
Integrated Bioinformatics Analysis of Serine Racemase as an Independent Prognostic Biomarker in Endometrial Cancer. [PDF]
Front Genet, 2022 Cui Z +7 more
europepmc +1 more source
The D-serine biosynthetic enzyme serine racemase is expressed by reactive astrocytes in the amygdala of human and a mouse model of Alzheimer's disease. [PDF]
Neurosci Lett, 2023 Folorunso OO +5 more
europepmc +1 more source
Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for \u3ci\u3eβ\u3c/i\u3e-elimination function [PDF]
, 2017 There is currently great interest in human serine racemase, the enzyme responsible for producing the NMDA co-agonist D-serine. Reported correlation of D-serine levels with disorders including Alzheimer’s disease, ALS, and ischemic brain damage (elevated ...
Graham, Danielle L. +4 more
core
PLoS ONEArsenic exposure model of offspring mice was established and intervened with 6-chlorobenzo[d]isoxazol-3-ol (CBIO), a D-amino acid oxidase (DAAO) inhibitor, to explore the role of DAAO in cognitive impairment of offspring mice induced by arsenic during ...
Zehua Niu +5 more
doaj +1 more source