Results 101 to 110 of about 4,545 (182)

Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain

Frontiers in Pharmacology, 2019
Research indicates that neurosteroids are locally synthesized in the central nervous system and play an important modulatory role in nociception. While the neurosteroidogenic enzyme, cytochrome P450 side-chain cleavage enzyme (P450scc), is the initiating
Sheu-Ran Choi, Alvin J. Beitz, Jang-Hern Lee   +2 more
doaj   +1 more source

Peripheral Biomarker for Vascular Disorders

Biomarker Insights, 2018
Atherosclerosis is the underlying cause of most myocardial infarction (MI) and ischaemic stroke episodes. An early sign of atherosclerosis is hypertrophy of the arterial wall.
Kaneez Fatima Shad, Nazar Luqman, Ann M Simpson, Sara Lal   +3 more
doaj   +1 more source

Identification of genes involved in osteoblast differentiation with an shRNA-based approach

, 2009
Mesenchymal stem cells (MSCs) derived from bone marrow and they can differentiate in a variety of cell types, including osteoblasts, adipocytes, chondrocytes, myoblasts, hepatocytes, and neural cells.
Cozzolino, Carmine
core  

Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy

Journal of Neuroinflammation, 2011
Background Recent data indicate that inflammatory mechanisms contribute to diabetic retinopathy (DR). We have determined that serine racemase (SR) expression is increased by inflammatory stimuli including liposaccharide (LPS), amyloid β-peptide (A-beta),
Yin Guibin, Wu Bo, Fang Junxu, Jiang Haiyan, Sun Lin, Qu Jia, Barger Steven W, Wu Shengzhou   +7 more
doaj   +1 more source

Structural and Functional Adaptation of Vancomycin Resistance VanT Serine Racemases

mBio, 2015
Vancomycin resistance in Gram-positive bacteria results from the replacement of the d-alanyl–d-alanine target of peptidoglycan precursors with d-alanyl–d-lactate or d-alanyl–d-serine (d-Ala-d-Ser), to which vancomycin has low binding affinity.
Djalal Meziane-Cherif, Peter J. Stogios, Elena Evdokimova, Olga Egorova, Alexei Savchenko, Patrice Courvalin   +5 more
doaj   +1 more source

Regulation and dynamics of human serine racemase

, 2014
Human serine racemase (hSR), predominantly localized in neu-rons and astrocytes, is a dimeric pyridoxal 5’-phosphate (PLP) enzyme that catalyzes the reversible racemization of L-serine toD-serine, the physiologically relevant co-agonist of N-methyl-D ...
Marchetti, M, Bruno, S, Mozzarelli, A, Peracchi, A, Campanini, B, Bettati, S   +5 more
core   +1 more source

D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).

, 2010
D-serine is an endogenous N-methyl-D-aspartate (NMDA) receptor coagonist. It is synthesized from L-serine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active D-amino acid oxidase ...
Cockayne, R, Harrison, PJ, Burnet, PW, Burnet, Philip, Sikka, P, Walker, R, Wood, MJ, Wood, Matthew, Harrison, Paul   +8 more
core   +2 more sources

Involvement of trimethylamine N-oxide in major depressive disorder via astrocytic d-Serine dysregulation

Neurotherapeutics
Trimethylamine N-oxide (TMAO), a co-metabolite of the gut microbiota and host, has been implicated in the pathogenesis of various neuropsychiatric disorders. However, its role in major depressive disorder (MDD) remains poorly understood.
Liwang Lin, Longyu Li, Shiao Ren, Liping Liu, Ying Liu, Wenlei Zhang, Zengliang Gao, Xiaoting Ni, Haoxuan Li, Xinsheng Duan, Sijing Tao, Tianyu Zhao, Xin Hai   +12 more
doaj   +1 more source

Astrocyte D-serine modulates the activation of neuronal NOS leading to the development of mechanical allodynia in peripheral neuropathy

Molecular Pain, 2019
Spinal D-serine plays an important role in nociception via an increase in phosphorylation of the N -Methyl-D-aspartate (NMDA) receptor GluN1 subunit (pGluN1). However, the cellular mechanisms underlying this process have not been elucidated.
Sheu-Ran Choi, Dae-Hyun Roh, Seo-Yeon Yoon, Hoon-Seong Choi, Suk-Yun Kang, Ho-Jae Han, Alvin James Beitz, Jang-Hern Lee   +7 more
doaj   +1 more source

Integrated Bioinformatics Analysis of Serine Racemase as an Independent Prognostic Biomarker in Endometrial Cancer. [PDF]

Front Genet, 2022
Cui Z, Mo J, Wang L, Wang R, Cheng F, Wang L, Yang X, Wang W.   +7 more
europepmc   +1 more source