Results 21 to 30 of about 14,981,197 (293)

Identifying sources of D-serine in Caenorhabditis elegans and their impact on behavior [PDF]

, 2021
Free D-serine (D-Ser) is a potent co-agonist of the N-methyl-D-aspartate receptor (NMDAR) in glutamate neurotransmission and regulates NMDAR functions in the nervous system.
Jonathan V., Sweedler, Nathan E., Schroeder, Nissa J., Larson, Tian A., Qiu, Harvey M., Andersen   +4 more
core   +2 more sources

Impairment of Executive Functions Associated With Lower D-Serine Serum Levels in Patients With Schizophrenia

Frontiers in Psychiatry, 2021
A core symptom that is frequently linked with dysregulation of glutamatergic neurotransmission in regard to schizophrenia is impairment or damage of executive functioning as a component of cognitive deficiency.
Jaromir Hons, Jaromir Hons, Rastislav Zirko, Martina Vasatova, Pavel Doubek, Blanka Klimova, Jiri Masopust, Jiri Masopust, Martin Valis, Kamil Kuca, Kamil Kuca   +10 more
doaj   +1 more source

Separation and detection of D-/L-serine by conventional HPLC

MethodsX, 2022
D-serine has a role as an endogenous allosteric agonist of N-methyl-D-aspartate (NMDA) receptor in the mammalian brain. In this study, we present a detailed description of our method that measures D-/L-serine by using conventional high performance liquid
Hiroki Shikanai, Kazuko Ikimura, Momoko Miura, Tsugumi Shindo, Akane Watarai, Takeshi Izumi   +5 more
doaj   +1 more source

Corrigendum: D-serine contributes to seizure development via ERK signaling [PDF]

Frontiers in Neuroscience
Tie Ma, Tie Ma, Yin Wu, Beibei Chen, Wenjuan Zhang, Lang Jin, Chenxi Shen, Yazhou Wang, Yonghong Liu   +8 more
doaj   +2 more sources

d-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens

Molecular Medicine, 2021
Objective d-Serine is a crucial endogenous co-agonist of N-methyl-d-aspartate receptors (NMDARs) in the central nervous system and can affect the function of the brain derived neurotrophic factor (BDNF) system, which plays an essential role in modulating
Zhenzhen Chen, Zhenyu Tang, Ke Zou, Zhihong Huang, Liuer Liu, Yuanjian Yang, Wei Wang   +6 more
doaj   +1 more source

D-Serine Metabolism and Its Importance in Development of Dictyostelium discoideum

Frontiers in Microbiology, 2018
In mammals, D-Ser is synthesized by serine racemase (SR) and degraded by D-amino acid oxidase (DAO). D-Ser acts as an endogenous ligand for N-methyl-D-aspartate (NMDA)- and δ2 glutamate receptors, and is involved in brain functions such as learning and ...
Tomokazu Ito, Natsuki Hamauchi, Taisuke Hagi, Naoya Morohashi, Hisashi Hemmi, Yukie G. Sato, Tamao Saito, Tohru Yoshimura   +7 more
doaj   +1 more source

Acute D-Serine Co-Agonism of β-Cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-Cell Membrane Activity

Cells, 2021
Insulin-secreting pancreatic β-cells express proteins characteristic of D-serine regulated synapses, but the acute effect of D-serine co-agonism on its presumptive β-cell target, N-methyl D-aspartate receptors (NMDARs), is unclear.
Amber Lockridge, Eric Gustafson, Alicia Wong, Robert F. Miller, Emilyn U. Alejandro   +4 more
doaj   +1 more source

Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: early detection of renal dysfunction using the ratio of serine enantiomers. [PDF]

PLoS ONE, 2014
The imbalance of blood and urine amino acids in renal failure has been studied mostly without chiral separation. Although a few reports have shown the presence of D-serine, an enantiomer of L-serine, in the serum of patients with severe renal failure, it
Jumpei Sasabe, Masataka Suzuki, Yurika Miyoshi, Yosuke Tojo, Chieko Okamura, Sonomi Ito, Ryuichi Konno, Masashi Mita, Kenji Hamase, Sadakazu Aiso   +9 more
doaj   +1 more source

The role of D-serine in peripheral tissues [PDF]

European Journal of Pharmacology, 2016
A considerable level of D-serine (a free D-amino acid) was discovered, surprisingly, in the mammalian brain in the early 1990s. Since then, D-serine has been considered to be a co-agonist of glutamate at the glycine site of NMDA receptors. D-serine is synthetized by racemization of L-serine in most neural and non-neural cells, and modulates a variety ...
Camila, Montesinos Guevara, Ali R, Mani
openaire   +2 more sources

D-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology

Neurology Research International, 2012
In mammalian systems, D-serine is perhaps the most biologically active D-amino acid described to date. D-serine is a coagonist at the NMDA-receptor, and receptor activation is dependent on D-serine binding. Because D-serine binding dramatically increases
John P. Crow, John C. Marecki, Misty Thompson   +2 more
doaj   +1 more source