Results 21 to 30 of about 10,883,538 (292)

Separation and detection of D-/L-serine by conventional HPLC

MethodsX, 2022
D-serine has a role as an endogenous allosteric agonist of N-methyl-D-aspartate (NMDA) receptor in the mammalian brain. In this study, we present a detailed description of our method that measures D-/L-serine by using conventional high performance liquid
Hiroki Shikanai, Kazuko Ikimura, Momoko Miura, Tsugumi Shindo, Akane Watarai, Takeshi Izumi   +5 more
doaj   +1 more source

d-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens

Molecular Medicine, 2021
Objective d-Serine is a crucial endogenous co-agonist of N-methyl-d-aspartate receptors (NMDARs) in the central nervous system and can affect the function of the brain derived neurotrophic factor (BDNF) system, which plays an essential role in modulating
Zhenzhen Chen, Zhenyu Tang, Ke Zou, Zhihong Huang, Liuer Liu, Yuanjian Yang, Wei Wang   +6 more
doaj   +1 more source

D-serine in health and disease

, 2010
Amino acids are among the most important molecules for living beings, since they are used to build peptides and proteins. Depending on their spatial positioning, amino acids can occur as D- or L-amino acids. This determines the function of peptides and proteins in the human body. It was long thought that only L-amino acids occurred in nature.
Fuchs, S.A., Child Health, Circulatory Health, Infection & Immunity, Metabole ziekten, Berger, R., Kimpen, JLL, de Koning,T.J., Klomp,L.W.J.   +8 more
openaire   +2 more sources

Acute D-Serine Co-Agonism of β-Cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-Cell Membrane Activity

Cells, 2021
Insulin-secreting pancreatic β-cells express proteins characteristic of D-serine regulated synapses, but the acute effect of D-serine co-agonism on its presumptive β-cell target, N-methyl D-aspartate receptors (NMDARs), is unclear.
Amber Lockridge, Eric Gustafson, Alicia Wong, Robert F. Miller, Emilyn U. Alejandro   +4 more
doaj   +1 more source

D-Serine Metabolism and Its Importance in Development of Dictyostelium discoideum

Frontiers in Microbiology, 2018
In mammals, D-Ser is synthesized by serine racemase (SR) and degraded by D-amino acid oxidase (DAO). D-Ser acts as an endogenous ligand for N-methyl-D-aspartate (NMDA)- and δ2 glutamate receptors, and is involved in brain functions such as learning and ...
Tomokazu Ito, Natsuki Hamauchi, Taisuke Hagi, Naoya Morohashi, Hisashi Hemmi, Yukie G. Sato, Tamao Saito, Tohru Yoshimura   +7 more
doaj   +1 more source

Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: early detection of renal dysfunction using the ratio of serine enantiomers. [PDF]

PLoS ONE, 2014
The imbalance of blood and urine amino acids in renal failure has been studied mostly without chiral separation. Although a few reports have shown the presence of D-serine, an enantiomer of L-serine, in the serum of patients with severe renal failure, it
Jumpei Sasabe, Masataka Suzuki, Yurika Miyoshi, Yosuke Tojo, Chieko Okamura, Sonomi Ito, Ryuichi Konno, Masashi Mita, Kenji Hamase, Sadakazu Aiso   +9 more
doaj   +1 more source

D-Serine as a putative glial neurotransmitter [PDF]

Neuron Glia Biology, 2004
Abundant recent evidence favors a neurotransmitter/neuromodulator role for D-serine. D-serine is synthesized from L-serine by serine racemase in astrocytic glia that ensheath synapses, especially in regions of the brain that are enriched in NMDA-glutamate receptors.
Asif K, Mustafa, Paul M, Kim, Solomon H, Snyder   +2 more
openaire   +2 more sources

Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo [PDF]

, 2013
N-methyl-d-aspartate receptor (NMDAR) activation can initiate changes in synaptic strength, evident as long-term potentiation (LTP), and is a key molecular correlate of memory formation.
Kerry L. Spear, Seth C. Hopkins, Hopkins, Seth C., David C. Spanswick, Heffernan, Michele L. R., Campbell, Una C., Ross D. Jeggo, Spear, Kerry L., Varney, Mark A., Michele L. R. Heffernan, Thomas H. Large, Spanswick, David C., Jeggo, Ross D., Mark A. Varney, Large, Thomas H., Una C. Campbell   +15 more
core   +1 more source

Identifying sources of D-serine in Caenorhabditis elegans and their impact on behavior

, 2021
Free D-serine (D-Ser) is a potent co-agonist of the N-methyl-D-aspartate receptor (NMDAR) in glutamate neurotransmission and regulates NMDAR functions in the nervous system.
Jonathan V., Sweedler, Nathan E., Schroeder, Nissa J., Larson, Tian A., Qiu, Harvey M., Andersen   +4 more
core   +1 more source

The role of D-serine in peripheral tissues [PDF]

European Journal of Pharmacology, 2016
A considerable level of D-serine (a free D-amino acid) was discovered, surprisingly, in the mammalian brain in the early 1990s. Since then, D-serine has been considered to be a co-agonist of glutamate at the glycine site of NMDA receptors. D-serine is synthetized by racemization of L-serine in most neural and non-neural cells, and modulates a variety ...
Camila, Montesinos Guevara, Ali R, Mani
openaire   +2 more sources