Results 41 to 50 of about 10,883,538 (292)
Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase
Frontiers in Molecular Biosciences, 2021 In the central nervous system, the flavoprotein D-amino acid oxidase is responsible for catabolizing D-serine, the main endogenous coagonist of N-methyl-D-aspartate receptor.
Silvia Sacchi +3 more
doaj +1 more source
Seprase: An overview of an important matrix serine protease [PDF]
, 2008 Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
O\u27Brien, Pamela +3 more
core +1 more source
The FASEB Journal, 2010 ABSTRACT d ‐Serine is thought to be a glia‐derived transmitter that activates N ‐methyl d ‐aspartate receptors (NMDARs) in the brain.
Dina, Rosenberg +5 more
openaire +3 more sources
Journal of Pharmacological Sciences, 2008 Recent studies indicate that an endogenous co-agonist for an N-methyl-D-aspartate (NMDA) receptor–related glycine site, D-serine, is synthesized by serine racemase and is metabolized by D-amino acid oxidase (DAO) and that acute treatment with morphine ...
Masanobu Yoshikawa +7 more
doaj +1 more source
PLoS ONE, 2013 BackgroundD-Serine, an endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, is synthesized from L-serine by serine racemase (SRR). Given the role of D-serine in both neurodevelopment and the pathophysiology of schizophrenia, we examined ...
Hiroko Hagiwara +2 more
doaj +1 more source
D-Serine reflects kidney function and diseases [PDF]
Scientific Reports, 2019 AbstractD-Amino acids, long-term undetected enantiomers of L-amino acids, are now emerging as potential biomarkers, especially for kidney diseases. Management of chronic kidney disease (CKD), a global problem with its high prevalence and poor prognosis, is currently unsatisfactory due to the difficulty in estimating kidney function and in early ...
Atsushi Hesaka +8 more
openaire +2 more sources
T-SP1: a novel serine protease-like protein predominantly expressed in testis [PDF]
, 2008 Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue.
Nerlich, Andreas +6 more
core +1 more source
Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior.
PLoS ONE, 2013 NMDA receptors are activated after binding of the agonist glutamate to the NR2 subunit along with a co-agonist, either L-glycine or D-serine, to the NR1 subunit.
David-Marian Otte +7 more
doaj +1 more source
, 2016 We report here the enantioselective synthesis of Boc-α-methyl-d-cysteine(PMB)-OH and lanthionine building blocks through the regioselective ring opening of key intermediate Boc-α-methyl-d-serine-β ...
Murray Goodman (2652340) +1 more
core +1 more source
Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D [PDF]
, 2007 Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases.
Kelly, April P. +3 more
core +1 more source