Results 41 to 50 of about 14,981,197 (293)
Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase
Frontiers in Molecular Biosciences, 2021 In the central nervous system, the flavoprotein D-amino acid oxidase is responsible for catabolizing D-serine, the main endogenous coagonist of N-methyl-D-aspartate receptor.
Silvia Sacchi +3 more
doaj +1 more source
The FASEB Journal, 2010 ABSTRACT d ‐Serine is thought to be a glia‐derived transmitter that activates N ‐methyl d ‐aspartate receptors (NMDARs) in the brain.
Dina, Rosenberg +5 more
openaire +3 more sources
d-Serine: A key to synaptic plasticity? [PDF]
The International Journal of Biochemistry & Cell Biology, 2012 Two discoveries have put D-serine in the spotlight of neuroscience. First, D-serine was detected in brain tissue at high levels. Second, it was found to act on the N-methyl-D-aspartate receptor (NMDAR). This receptor is central to use-dependent synaptic plasticity, the cellular process which is widely believed to underlie learning.
Christian, Henneberger +2 more
openaire +2 more sources
Journal of Pharmacological Sciences, 2008 Recent studies indicate that an endogenous co-agonist for an N-methyl-D-aspartate (NMDA) receptor–related glycine site, D-serine, is synthesized by serine racemase and is metabolized by D-amino acid oxidase (DAO) and that acute treatment with morphine ...
Masanobu Yoshikawa +7 more
doaj +1 more source
, 2010 D-serine is an endogenous N-methyl-D-aspartate (NMDA) receptor coagonist. It is synthesized from L-serine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active D-amino acid oxidase ...
Wood, Matthew J. A., +5 more
core +2 more sources
PLoS ONE, 2013 BackgroundD-Serine, an endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, is synthesized from L-serine by serine racemase (SRR). Given the role of D-serine in both neurodevelopment and the pathophysiology of schizophrenia, we examined ...
Hiroko Hagiwara +2 more
doaj +1 more source
, 2016 We report here the enantioselective synthesis of Boc-α-methyl-d-cysteine(PMB)-OH and lanthionine building blocks through the regioselective ring opening of key intermediate Boc-α-methyl-d-serine-β ...
Murray Goodman (2652340) +1 more
core +1 more source
Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior.
PLoS ONE, 2013 NMDA receptors are activated after binding of the agonist glutamate to the NR2 subunit along with a co-agonist, either L-glycine or D-serine, to the NR1 subunit.
David-Marian Otte +7 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2017 The roles of D-serine in depression are raised concerned recently as an intrinsic co-agonist for the NMDA receptor. However, the mechanisms underlying its regulation are not fully elucidated. ASCT2 is a Na+-dependent D-serine transporter.
Jiesi Wang +13 more
doaj +1 more source
Translational Psychiatry, 2021 d-Serine acts as a co-agonist of N-methyl-d-aspartate receptors (NMDAR) which appear overactivated in AD, while d-aspartate is a modulatory molecule acting on NMDAR as a second agonist.
Luciano Piubelli +6 more
doaj +1 more source