Amperometric Self-Referencing Ceramic Based Microelectrode Arrays for D-Serine Detection [PDF]
Biosensors, 2018 D-serine is the major D-amino acid in the mammalian central nervous system. As the dominant co-agonist of the endogenous synaptic NMDA receptor, D-serine plays a role in synaptic plasticity, learning, and memory.
Diana Campos-Beltrán +3 more
doaj +2 more sources
D-serine and serine racemase are associated with PSD-95 and glutamatergic synapse stability [PDF]
Frontiers in Cellular Neuroscience, 2016 D-serine is an endogenous coagonist at the glycine site of synaptic NMDA receptors (NMDARs), synthesized by serine racemase (SR) through conversion of L-serine. It is crucial for synaptic plasticity and is implicated in schizophrenia.
Hong eLin +6 more
doaj +2 more sources
Metabolism of the neuromodulator D-serine
Cellular and Molecular Life Sciences, 2010 Over the past years, accumulating evidence has indicated that d-serine is the endogenous ligand for the glycine-modulatory binding site on the NR1 subunit of N-methyl-d-aspartate receptors in various brain areas.
POLLEGIONI, LOREDANO, SACCHI, SILVIA
core +4 more sources
Chronic d-serine supplementation impairs insulin secretion [PDF]
Molecular Metabolism, 2018 Objective: The metabolic role of d-serine, a non-proteinogenic NMDA receptor co-agonist, is poorly understood. Conversely, inhibition of pancreatic NMDA receptors as well as loss of the d-serine producing enzyme serine racemase have been shown to ...
Lisa Suwandhi +21 more
doaj +2 more sources
Clinical and biochemical study of D-serine metabolism among schizophrenia patients
Neuropsychiatric Disease and Treatment, 2017 Hamdy N El-Tallawy,1 Tahia H Saleem,2 Abdallah MAA El-Ebidi,3 Mohammed H Hassan,4 Romany H Gabra,1 Wafaa MA Farghaly,1 Nagwa Abo El-Maali,5 Hoda S Sherkawy3 1Department of Neuropsychiatry, 2Department of Medical Biochemistry and Molecular Biology ...
El-Tallawy HN +7 more
doaj +1 more source
Induction of serine racemase expression and
Journal of Neuroinflammation, 2004 Background Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid β-peptide (Aβ), elicit a release of glutamate from microglia. We tested the possibility that a coagonist at the
Griffin W Sue T +5 more
doaj +2 more sources
When and where? Pathogenic Escherichia coli differentially sense host D-serine using a universal transporter system to monitor their environment [PDF]
Microbial Cell, 2016 Sensing environmental stimuli is critically important for bacteria when faced with the multitude of adversities presented within the host. Responding appropriately to these signals and in turn integrating these responses into the regulatory network of ...
James P. R. Connolly, Andrew J. Roe
doaj +2 more sources
Fabrication and use of D-serine biosensors for characterising D-serine signalling in rat brain [PDF]
D-serine is a co-agonist at NMDA receptors in the brain but the study of this amino acid is restricted by current techniques. I have designed highly sensitive D-serine biosensors that permit accurate real-time recordings of D-serine in the brain in a ...
Bibi, Shakila
core +2 more sources
D-Serine as a sensor and effector of the kidney. [PDF]
Clin Exp Nephrol, 2023 Abstractd-Serine, a rare enantiomer of serine, is a biomarker of kidney disease and function. The level of d-serine in the human body is precisely regulated through the urinary clearance of the kidney, and its clearance serves as a new measure of glomerular filtration rate with a lower bias than creatinine clearance.
Kimura T, Sakai S, Isaka Y.
europepmc +3 more sources
d-Serine Increases Release of Acetylcholine in Rat Submandibular Glands. [PDF]
Biology (Basel), 2023 d-serine has been observed in submandibular gland tissue in rats, but its functions remain to be clarified. Oral administration of d-serine, but not l-serine, increased its concentrations in the submandibular gland and pilocarpine-induced salivary ...
Yoshikawa M +4 more
europepmc +2 more sources