Results 101 to 110 of about 14,287,062 (240)

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

The Synthesis of L-tryptophan Degrading Bioreactors

, 1990
To design a bioreactor for removing the potential cancer nutrient L-tryptophan from blood, the L-tryptophan degrading enzyme tryptophan side chain oxydase (TSO) was chemically bound to glutaraldehyde activated gamma amino silane silica and to ...
M.B. Dennis, G. Schmer, S. Hsueh, K.C. Hou   +3 more
core   +1 more source

ALE reveals a surprising link between [Fe-S] cluster formation, tryptophan biosynthesis and the potential regulatory protein TrpP in Corynebacterium glutamicum

BMC Microbiology
Background The establishment of synthetic microbial communities comprising complementary auxotrophic strains requires efficient transport processes for common goods. With external supplementation of the required metabolite, most auxotrophic strains reach
Rico Zuchowski, Simone Schito, Christina Mack, Astrid Wirtz, Michael Bott, Tino Polen, Stephan Noack, Meike Baumgart   +7 more
doaj   +1 more source

Scientific Opinion on the safety and efficacy of L‐tryptophan, technically pure, produced by Escherichia coli strains DSM 25084, KCCM 11132P or SARI12091203 for all animal species based on a dossier submitted by AMAC EEIG

EFSA Journal, 2015
The product L‐tryptophan is a nutritional feed additive produced by fermentation using one of three strains of Escherichia coli. L‐Tryptophan produced by E.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source

The transport of L-tryptophan into slices of rat cerebral cortex.

, 1974
Rat cerebral cortex slices incubated aerobically at 37ºC in Krebs-Rinqer phosphate medium containing 10 mM glucose and 1.0 mM L-tryptophan-(carboxyl-14C) accumulated L-tryptophan. Uptake of L-tryptophan was linear for the first 15-20 min.
Kiely, Maureen E.
core  

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Synthesis and Characterization of Poly(ethylene glycol)-block-Poly(N(alpha)-Boc-L-tryptophan) copolymers

, 2010
Synthesis and Characterization of Poly(ethylene glycol)-block-Poly(N(alpha)-Boc-L-tryptophan ...
AS Voda (14541038), Q Guo (3556889)
core  

Diverging Liquid–Liquid Phase Separation Behavior of Different Recombinant Major Ampullate Spidroins

Advanced Science, EarlyView.
Fibers spun from the MaSp1‐derivative as well as MaSp1‐MaSp2‐mixtures provide a deeper insight into the assembly process of the spidroins and how hierarchical architectures of spider silk fibers could be achieved. ABSTRACT Spider silk fibers show exceptional mechanical properties, based on their underlying spider silk proteins (spidroins) as well as a ...
Tim Schiller, Cheryl Hayashi, Thomas R. Scheibel   +2 more
wiley   +1 more source

Dietary tryptophan intervention on growth and stress of Asian seabass, Lates calcarifer reared in recirculating aquaculture system

Journal of Fisheries
The rapid expansion of recirculating aquaculture system (RAS) aquaculture demands precise dietary strategies. Determining optimal tryptophan levels and understanding their combined effects on growth, blood responses, and stress regulation in Asian ...
Manikandan Kalidoss, Nathan Felix, Elangovan Prabu   +2 more
doaj   +1 more source