Results 161 to 170 of about 51,633,057 (277)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Impact of Ca_V1.3 L-Type Calcium Channels on Arrhythmogenesis in Cancer. [PDF]

Int J Mol Sci
Distor LJG, Sleiman Y, Reisqs JB, Ginjupalli VKM, Cupelli M, Boutjdir M.   +5 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Aging Disrupts L-type Ca²⁺ Channel Organization and Function in Pacemaker Cells. [PDF]

Circ Res
Vivas O, Baudot M, Madden R, Piñon-Teal WL, Hunt MS, Choi S, Pournejati R, Flores-Tamez VA, Santana LF, Moreno CM.   +9 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Neuropeptide Y deficiency perturbs L-type calcium and outward potassium currents leading to ventricular arrhythmogenesis in mice. [PDF]

J Clin Invest
Elasoru SE, Miccile C, Pan J, Zhang Z, Shivkumar K, Herzog H, Harvey RD, Qu Z, Ajijola OA.   +8 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Manuscript: Lincoln's Type in Business

, 2013
Manuscript: Lincoln's Type in ...
Tarbell, Ida M.
core  

On the role of L-type Ca2+ and BK channels in a biophysical model of cartwheel interneurons. [PDF]

PLoS Comput Biol
Martin M, Rubin JE, Pedersen MG.
europepmc   +1 more source

Regulation of Cardiac L-Type Calcium Channels by Protein Kinase A and Protein Kinase C

Circulation Research, 2000
T. Kamp, J. Hell
semanticscholar   +1 more source