Results 171 to 180 of about 51,633,057 (277)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Modulation of L-Type Calcium Currents by Resveratrol-Induced Myogenesis in C2C12 Cells. [PDF]

Cells
Biagini A, Sallicandro L, Covarelli J, Gentile R, Mirarchi A, Farinelli A, Reali G, Del Bianco D, Quellari PT, Gliozheni E, Malvasi A, Baldini GM, Trojano G, Tubaro C, Bearzi C, Rizzi R, Arcuri C, Prontera P, Tinelli A, Fioretti B.   +19 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The role of L-type amino acid transporter 1 in the pathogenicity of <i>Candida albicans</i>. [PDF]

Microbiol Spectr
Lan Y, Wu C, Du P, Jiao J, Li C, Chu K, Zhang T, Chen P, Li A, Xu W, Ying X, Zhou J, Lin W, Ma L, Huang Y.   +14 more
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

L-type calcium channel-mediated lipid metabolic reprogramming in gastric adenocarcinoma progression. [PDF]

Transl Oncol
Cui M, Cheng S, Wen X, Yang H, Huang Y, Pan L, Wei S, Huang H.   +7 more
europepmc   +1 more source

Transport of 3-Fluoro-l-α-Methyl-Tyrosine by Tumor-Upregulated L-Type Amino Acid Transporter 1: A Cause of the Tumor Uptake in PET

Journal of Nuclear Medicine, 2012
Pattama Wiriyasermkul, S. Nagamori, Hideyuki Tominaga, N. Oriuchi, K. Kaira, Hidekazu Nakao, Takeru Kitashoji, Ryuichi Ohgaki, Hidekazu Tanaka, H. Endou, K. Endo, H. Sakurai, Y. Kanai   +12 more
semanticscholar   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Anti-Tumor Potential of Selective L-Type Amino Acid Transporter (LAT1) Inhibitor, JPH203, in Patient-Derived Canine Bladder Cancer Organoids. [PDF]

Int J Mol Sci
Yu TW, Kawahashi M, Goda F, Kanaya A, Elbadawy M, Endou H, Ide S, Yamawaki H, Kaneda M, Abugomaa A, Uchide T, Usui T, Sasaki K.   +12 more
europepmc   +1 more source

CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease

Nature Communications, 2012
Soosung Kang, Garry Cooper, S. F. Dunne, Brendon E. Dusel, Chi-Hao Luan, D. J. Surmeier, Richard B. Silverman   +6 more
semanticscholar   +1 more source