Results 191 to 200 of about 51,633,057 (277)

L-Type Ca_v1.3 and HCN Channels Mediate Heart Rate Acceleration by Catecholamines. [PDF]

Circ Res
Torre E, Faure M, Bidaud I, Baudot M, Gaillardon M, Pereira de Vasconcelos W, Laarioui S, Talssi L, Engeland B, Reiken S, Saponaro A, Chen BX, Moroni A, D'Souza A, Isbrandt D, Marks AR, Marx SO, Mesirca P, Mangoni ME.   +18 more
europepmc   +1 more source

Neuronal CaV1.3α1 L-Type Channels Activate at Relatively Hyperpolarized Membrane Potentials and Are Incompletely Inhibited by Dihydropyridines

Journal of Neuroscience, 2001
Weifeng Xu, D. Lipscombe
semanticscholar   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

C-Terminus of Ca_v1.3 L-Type Ca²⁺ Channel Upregulates Its Own Gene Expression. [PDF]

Cells
Sleiman Y, Srivastava U, Reisqs JB, Wadgaonkar R, Qu YS, Pouliot V, Chahine M, Boutjdir M.   +7 more
europepmc   +1 more source

Early Afterdepolarizations: Mechanism of Induction and Block A Role for L‐Type Ca2+ Current

Circulation Research, 1989
C. January, J. Riddle
semanticscholar   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Downregulation of L-type Ca²⁺ current in patients with atrial fibrillation results from altered channel gating and disruption of membrane microdomains. [PDF]

Heart Rhythm
Balycheva M, Reilly-O'Donnell B, Alvarez-Laviada A, Zhang K, Mazzola M, Sanchez-Alonso JL, Lucarelli C, Medvedev RY, Molina CE, Schobesberger S, Diakonov I, Wright PT, Poulet CE, Bork NI, Trayanova NA, Faggian G, Punjabi P, Nikolaev VO, Glukhov AV, Gorelik J.   +19 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A novel computational model of human iPSC-derived ventricular myocytes with improved L-type calcium current for application to Timothy syndrome. [PDF]

Sci Rep
Simone F, Trancuccio A, Sochacki JK, Prieto CM, Priori SG, Pavarino LF, Santiago DJ.   +6 more
europepmc   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source