Results 181 to 190 of about 9,297 (211)
Application of CRISPR/Cas9-Based Reverse Genetics in Leishmania braziliensis: Conserved Roles for HSP100 and HSP23 [PDF]
Genes, 2020 : The protozoan parasite Leishmania (Viannia) braziliensis (L. braziliensis) is the main cause of human tegumentary leishmaniasis in the New World, a disease affecting the skin and/or mucosal tissues.
Vanessa Adauí +2 more
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International Journal of Pharmaceutics, 2022
The search for effective and less toxic drugs for the treatment of Cutaneous Leishmaniasis (CL) is desirable due to the emergence of resistant parasites. The present study shows the preparation, characterization and in vitro antileishmanial activity of green-based silver nanoparticles (AgNPs) with Cashew Nutshell Liquid (CNSL, main constituents ...
Teixeira Bezerra, Thayllan +9 more
openaire +3 more sources
The search for effective and less toxic drugs for the treatment of Cutaneous Leishmaniasis (CL) is desirable due to the emergence of resistant parasites. The present study shows the preparation, characterization and in vitro antileishmanial activity of green-based silver nanoparticles (AgNPs) with Cashew Nutshell Liquid (CNSL, main constituents ...
Teixeira Bezerra, Thayllan +9 more
openaire +3 more sources
The American Journal of Tropical Medicine and Hygiene, 1988
Pyrazolopyrimidines, particularly allopurinol, allopurinol riboside, and other purine analogues, show promise as experimental therapeutic compounds for the treatment of leishmaniasis. The combination of these agents with pentostam may produce an improved therapeutic effect.
S, Martinez +3 more
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Pyrazolopyrimidines, particularly allopurinol, allopurinol riboside, and other purine analogues, show promise as experimental therapeutic compounds for the treatment of leishmaniasis. The combination of these agents with pentostam may produce an improved therapeutic effect.
S, Martinez +3 more
openaire +2 more sources
Molecular and Biochemical Parasitology, 1993
Promastigotes of Leishmania mexicana and Leishmania braziliensis incorporate S-adenosyl-L-[3H-methyl]methionine (AdoMet) against a concentration gradient through a saturable system. This concentrative uptake requires metabolic energy and is sensitive to temperature and sulfhydryl reagents such as N-ethyl maleimide.
J L, Avila, M A, Polegre
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Promastigotes of Leishmania mexicana and Leishmania braziliensis incorporate S-adenosyl-L-[3H-methyl]methionine (AdoMet) against a concentration gradient through a saturable system. This concentrative uptake requires metabolic energy and is sensitive to temperature and sulfhydryl reagents such as N-ethyl maleimide.
J L, Avila, M A, Polegre
openaire +2 more sources
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1992
Between 1975 and 1987, epidemiological studies were carried out in several rural and urban communities in the central part of western Venezuela, especially in the state of Lara. 115 positive cultures were obtained from human cases and identified by their reactivity patterns to a cross-panel of specific monoclonal antibodies using a radioimmune binding ...
R, Bonfante-Garrido +7 more
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Between 1975 and 1987, epidemiological studies were carried out in several rural and urban communities in the central part of western Venezuela, especially in the state of Lara. 115 positive cultures were obtained from human cases and identified by their reactivity patterns to a cross-panel of specific monoclonal antibodies using a radioimmune binding ...
R, Bonfante-Garrido +7 more
openaire +2 more sources
Transboundary and emerging diseases, 2022
Leishmaniasis is caused by protozoans of the Leishmania genus, which includes more than 20 species capable of infecting humans worldwide. In the Americas, the most widespread specie is L. braziliensis, present in 18 countries including Bolivia. The taxonomic position of the L.
Mary Cruz, Torrico +13 more
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Leishmaniasis is caused by protozoans of the Leishmania genus, which includes more than 20 species capable of infecting humans worldwide. In the Americas, the most widespread specie is L. braziliensis, present in 18 countries including Bolivia. The taxonomic position of the L.
Mary Cruz, Torrico +13 more
openaire +1 more source
Diagnostic Microbiology and Infectious Disease, 2014
The aim of this study was to evaluate the effectiveness of polymerase chain reaction (PCR) using Kinetoplastid DNA (kDNA) from nasal swabs (NSs), saliva, and oral filter paper imprints (OFPI) in diagnosing mucocutaneous leishmaniasis (ML) and cutaneous leishmaniasis (CL).
Ciro M, Gomes +4 more
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The aim of this study was to evaluate the effectiveness of polymerase chain reaction (PCR) using Kinetoplastid DNA (kDNA) from nasal swabs (NSs), saliva, and oral filter paper imprints (OFPI) in diagnosing mucocutaneous leishmaniasis (ML) and cutaneous leishmaniasis (CL).
Ciro M, Gomes +4 more
openaire +2 more sources
The American Journal of Tropical Medicine and Hygiene, 1997
The growth inhibitory effect of 3-deazaneplanocin A (c3NpcA) was tested against some pathogenic members of the family of American Trypanosomatidae. Under our culture conditions, c3NpcA displayed a strongly and uniformly leishmanistatic effect on all 23 American Leishmania (L. mexicana and L.
J L, Avila +3 more
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The growth inhibitory effect of 3-deazaneplanocin A (c3NpcA) was tested against some pathogenic members of the family of American Trypanosomatidae. Under our culture conditions, c3NpcA displayed a strongly and uniformly leishmanistatic effect on all 23 American Leishmania (L. mexicana and L.
J L, Avila +3 more
openaire +2 more sources
World Journal of Microbiology and Biotechnology
The development of leishmaniasis depends on the ability of Leishmania to invade and survive within macrophages. Macrophages can either promote parasite elimination or support its survival, depending on whether they are classically (M1) or alternatively (M2) activated.
André Murilo de Souza Marques +6 more
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The development of leishmaniasis depends on the ability of Leishmania to invade and survive within macrophages. Macrophages can either promote parasite elimination or support its survival, depending on whether they are classically (M1) or alternatively (M2) activated.
André Murilo de Souza Marques +6 more
openaire +2 more sources
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1983
Kinetoplast DNA (kDNA), initially characterized by buoyant density, from ten reference isolates of the Leishmania braziliensis and L. mexicana complexes has been radio-actively labelled and used as hybridization probes. Filters containing endonuclease digested, electrophoresed, Southern transferred fragments of kDNA from reference and other isolates ...
D C, Barker, J, Butcher
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Kinetoplast DNA (kDNA), initially characterized by buoyant density, from ten reference isolates of the Leishmania braziliensis and L. mexicana complexes has been radio-actively labelled and used as hybridization probes. Filters containing endonuclease digested, electrophoresed, Southern transferred fragments of kDNA from reference and other isolates ...
D C, Barker, J, Butcher
openaire +2 more sources