Results 161 to 170 of about 3,155 (197)

Gene structure of the carp fish ribosomal protein L41: seasonally regulated expression [PDF]

open access: yesBiochemical and Biophysical Research Communications, 2002
The seasonal acclimatization of the carp fish demands physiological compensatory responses. The process involves profound nucleolar adjustments and remarkable changes in rRNA synthesis, which affect ribosomal biogenesis. We have documented that protein kinase CK2, whose activity is related to ribosomal protein L41 and the regulation of rRNA synthesis ...
Alfredo Molina   +2 more
exaly   +7 more sources

Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25–35 peptide administration in mice [PDF]

open access: yesEuropean Neuropsychopharmacology, 2015
Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases (CLKs) are implicated in the onset and progression of Down syndrome (DS) and Alzheimer's disease (AD). DYRK1A has emerged as a possible link between amyloid-β (Aβ) and Tau, the major pathological proteins in AD.
Gaëlle Naert   +2 more
exaly   +5 more sources

cdc-Like/Dual-Specificity Tyrosine Phosphorylation–Regulated Kinases Inhibitor Leucettine L41 Induces mTOR-Dependent Autophagy: Implication for Alzheimer’s Disease [PDF]

open access: yesMolecular Pharmacology, 2014
Leucettines, a family of pharmacological inhibitors of dual-specificity tyrosine phosphorylation regulated kinases and cdc-like kinases (CLKs), are currently under investigation for their potential therapeutic application to Down syndrome and Alzheimer's disease.
Emilie Durieu   +2 more
exaly   +4 more sources

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