A Gcn4p Homolog Is Essential for the Induction of a Ribosomal Protein L41 Variant Responsible for Cycloheximide Resistance in the Yeast Candida maltosa [PDF]
Journal of Biological Chemistry, 2004 Cycloheximide (CYH) resistance in the yeast Candida maltosa is based on the inducible expression of genes encoding a variant of ribosomal protein L41-Q, with glutamine at position 56 instead of the proline found in normal L41. The promoter of L41-Q2a, one of the L41-Q gene alleles encoding L41-Q, has an element similar to the Gcn4p-responsive element ...
Akinori Ohta
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7B6, a ubiquitous mRNA: with significant homology to L41 human ribosomal protein RNA
Nucleic Acids Research, 1993 S E, Francis, G W, Duff
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The Primary Structures of Rat Ribosomal Proteins L4 and L41
Biochemical and Biophysical Research Communications, 1995The amino acid sequences of the rat 60S ribosomal subunit proteins L4 and L41 were deduced from the sequences of nucleotides in recombinant cDNAs. Ribosomal protein L4 has 421 amino acids; the molecular weight is 47,280. L41 is the smallest ribosomal protein; it has 25 amino acids and a molecular weight of 3,454.
Y L, Chan, J, Olvera, I G, Wool
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Biochemical and Biophysical Research Communications, 1997 Protein kinase CKII (CKII) is a heterotetramer composed of two catalytic (alpha or alpha') and two regulatory (beta) subunits. Using the yeast two-hybrid system, we have identified the highly basic, ribosomal protein L41 as a cellular protein capable of interacting with the beta subunit of CKII.
Young-Seuk Bae
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Genomic structure of the human ribosomal protein L41 gene [PDF]
IUBMB Life, 1998 AbstractUsing PCR technique, genomic DNA encoding the gene of the human ribosomal protein L41 was amplified. Subsequent sequencing showed that the gene was constituted with 4 exons and 3 introns. Because the amplified gene contained introns and whole the open reading frame, we concluded the fragment corresponded to the functional gene.
H, Go, K, Miyado, S, Taniguchi
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cdc-Like/Dual-Specificity Tyrosine Phosphorylation–Regulated Kinases Inhibitor Leucettine L41 Induces mTOR-Dependent Autophagy: Implication for Alzheimer’s Disease [PDF]
Molecular Pharmacology, 2014 Leucettines, a family of pharmacological inhibitors of dual-specificity tyrosine phosphorylation regulated kinases and cdc-like kinases (CLKs), are currently under investigation for their potential therapeutic application to Down syndrome and Alzheimer's disease.
Gaetan Chicanne +2 more
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Drastic alteration of cycloheximide sensitivity by substitution of one amino acid in the L41 ribosomal protein of yeasts [PDF]
Journal of Bacteriology, 1992 Cycloheximide is one of the antibiotics that inhibit protein synthesis in most eukaryotic cells. We have found that a yeast, Candida maltosa, is resistant to the drug because it possesses a cycloheximide-resistant ribosome, and we have isolated the gene responsible for this.
S, Kawai +5 more
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Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25–35 peptide administration in mice [PDF]
European Neuropsychopharmacology, 2015 Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases (CLKs) are implicated in the onset and progression of Down syndrome (DS) and Alzheimer's disease (AD). DYRK1A has emerged as a possible link between amyloid-β (Aβ) and Tau, the major pathological proteins in AD.
Johann Meunier +2 more
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The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
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L41. Perspectives on the treatment of giant cell arteritis
Presse Medicale, 2013exaly +3 more sources