Results 11 to 20 of about 186,409 (108)

Species variation in the cartilaginous endplate of the lumbar intervertebral disc. [PDF]

JOR Spine, 2022
Species variation in the CEP of lumbar IVDs was determined based on histology and SEM analysis. The integration of BEP‐CEP in humans, pigs, goats, and rabbits was mainly achieved by the collagen bundles anchoring system, while the typical BEP‐CEP interface did not exist in rats.
Li YH, Wu HL, Li Z, Li BB, Zhu M, Chen D, Ye FH, Yu BS, Huang YC.   +8 more
europepmc   +2 more sources

Design and Characterization of a Novel eEF2K Degrader with Potent Therapeutic Efficacy Against Triple-Negative Breast Cancer. [PDF]

Adv Sci (Weinh)
Dysregulated eukaryotic elongation factor 2 kinase (eEF2K) expression is implicated in the pathogenesis of triple‐negative breast cancer (TNBC). Compound C1 is designed and synthesized, which shows potent activity in degrading eEF2K protein. C1 significantly inhibits the proliferation and metastasis of TNBC.
Zhong C, Zhu R, Jiang T, Tian S, Zhao X, Wan X, Jiang S, Chen Z, Gong R, He L, Yang JM, Ye N, Cheng Y.   +12 more
europepmc   +2 more sources

Towards Platinum(II) Complexes for in cellulo Applications: Synthesis, Characterization, Biological and Catalytic Evaluation

Helvetica Chimica Acta, Volume 106, Issue 8, August 2023., 2023
Abstract With the aim of achieving bioorthogonal intracellular catalysis, a library of platinum(II) complexes was synthesized. Their non‐toxicity to living cells was demonstrated and their catalytic activity was evaluated on a cyclization reaction leading to a highly fluorescent coumarin. None of the platinum complexes showed any catalytic activity for
Lisa Gourdon‐Grünewaldt, Marija Bakija, Lara Wild, Berislav Perić, Gilles Gasser, Srećko I. Kirin, Kevin Cariou   +6 more
wiley   +1 more source

Synthesis of Geminal Bis‐ and Tetrakisphosphonate Ester Derivatives and Their Coordination Behavior Towards Ca(II) Ions

European Journal of Inorganic Chemistry, Volume 2022, Issue 17, June 17, 2022., 2022
Geminal Bisphosphonate (BP) Esters in Ca(II) Ion Coordination. A series of geminal BPs was prepared starting from their corresponding ethyl‐ or isopropyl (arylmethylene)phosphonate ester precursors. Complexation with CaCl2 yields the derived coordination compounds [Ca(H2O)2(L1–L3)2]Cl2 or [Ca(L8)Cl2]n.
Ingo Koehne, Rudolf Pietschnig
wiley   +1 more source

Mathematical Modelling of the Spatial Epidemiology of COVID‐19 with Different Diffusion Coefficients

International Journal of Differential Equations, Volume 2022, Issue 1, 2022., 2022
This paper addresses the discrepancy between model findings and field data obtained and how it is minimized using the binning smoothing techniques: means, medians, and boundaries. Employing both the quantitative and the qualitative methods to examine the complex pattern involved in COVID‐19 transmission dynamics reveals model variation and provides a ...
Benedict Barnes, Ishmael Takyi, Bright Emmanuel Owusu, Francis Ohene Boateng, Augustine Saahene, Emmanuel Saarah Baidoo, Jennifer Aduko Adombire, Giovanni P. Galdi   +7 more
wiley   +1 more source

Gifted child in kindergarten – assessment pitfalls

Forum Pedagogiczne, 2020
Issues and considerations raised in the article are related to the identification (assessment) of gifted children, often described in literature, in relation to selected theories  of ability.
Elżbieta Kwiatkowska
doaj   +1 more source

Początkujący nauczyciel przedszkola we wspólnocie zawodowej. Od niepewności ku pełnemu uczestnictwu w socjokulturowych praktykach

Forum Pedagogiczne, 2020
Celem artykułu jest przedstawienie społecznego wymiaru uczenia się profesji przez początkującego nauczyciela przedszkola, wagi, jaką w tym procesie może zajmować uczestniczenie w socjokulturowych praktykach wspólnoty.
Magdalena Grochowalska
doaj   +1 more source

A Liquid Chromatography with Tandem Mass Spectrometry‐Based Proteomic Analysis of Primary Cultured Cells and Subcultured Cells Using Mouse Adipose‐Derived Mesenchymal Stem Cells

Stem Cells International, Volume 2019, Issue 1, 2019., 2019
Adipose‐derived mesenchymal stem cells (MSC‐ATs) are representative cell sources for cell therapy. However, how cell stress resulting from passage influences the MSC‐AT protein expression has been unclear. In this study, a protein expression analysis was performed by liquid chromatography with tandem mass spectrometry (LC‐MS/MS) using mouse primary ...
Yoshiki Nakashima, Saifun Nahar, Chika Miyagi-Shiohira, Takao Kinjo, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, Jiro Fujita, Hirofumi Noguchi, Katia Mareschi   +9 more
wiley   +1 more source

Leadership in Educational Institutions: Shared Duty and Joint Responsibility

Forum Pedagogiczne, 2020
In the present world changes are inevitable and modern schools will also be presented to them. School principals should, therefore, aim at transforming the institutions into learning organizations, thus gathering people capable of self-reflection and ...
Joanna Ludwika Pękala, Wiktoria Kowalska   +1 more
doaj   +1 more source

Interface Data Modeling to Detect and Diagnose Intersystem Faults for Designing and Integrating System of Systems

Complexity, Volume 2018, Issue 1, 2018., 2018
In system of systems engineering, system integrators are in charge of compatible and reliable interfaces between subsystems. This study explains a systematic solution to identify and diagnose interface faults during designing and integrating systems of systems.
Kyung-Min Seo, Kwang-Phil Park, Zhiwei Gao   +2 more
wiley   +1 more source