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Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.
Biochemical and Biophysical Research Communications, 1994L86-8275 [(-) cis-5,7-dihydroxy-2-(2-chlorophenyl)-8[4-(3-hydroxy-1- methyl)-piperidinyl]-4H-benzopyran-4-one] directly inhibits immunoprecipitated Cdc2 kinase activity from G2/M synchronized MDA-MB-468 breast carcinoma cells and is at least 250-fold more potent than either quercetin or genistein.
M. Losiewicz +4 more
semanticscholar +8 more sources
Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy.
International Journal of Oncology, 1996Flavopiridol is a new synthetic flavone, structurally related to a natural alkaloid, originally purified from Dysoxylum binectariferum, a plant indigenous to India and used in Indian folk medicine. Flavopiridol was detected by a tandem screening system consisting in inhibition of the EGF-receptor Tyrosine phosphokinase and cytotoxicity. As a cytostatic
H. Sedlacek +10 more
semanticscholar +3 more sources
Long-term outcome of L86 and L97 protocols for adult acute lymphoblastic leukemia
Leukemia & Lymphoma, 2008We analysed the long-term outcome of the L86 protocol using L-asparaginase (L-asp), vincristine (VCR) and prednisolone (PSL), collectively known as LVP or L97 protocol using LVP along with pirarubicin hydrochloride (THP-ADR) for 97 patients with acute lymphoblastic leukemia (ALL) diagnosed between 1986 and 2002.
H. Koharazawa +16 more
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Application of Modified Flavone Closure for the Preparation of Racemic L86-8275
Organic Process Research & Development, 1999The laboratory preparation of racemic L86-8275 (1a) and the salt (1b) is described in 7% overall yield. Our method eliminated a number of chromatography steps from the patent procedure and improved the flavone-forming reaction by employing a stepwise mechanism. Solvent-free conditions for the demethylation step are also described.
A. Tabaka +3 more
semanticscholar +2 more sources
Cancer Chemotherapy and Pharmacology, 1998
Flavopiridol is a flavone which inhibits several cyclin-dependent kinases, and exhibits potent growth-inhibitory activity against a number of human tumor cell lines both in vitro, and when grown as xenografts in mice. It is currently being evaluated in a phase I clinical trial at the National Cancer Institute.
S. Stinson +4 more
semanticscholar +3 more sources
Flavopiridol is a flavone which inhibits several cyclin-dependent kinases, and exhibits potent growth-inhibitory activity against a number of human tumor cell lines both in vitro, and when grown as xenografts in mice. It is currently being evaluated in a phase I clinical trial at the National Cancer Institute.
S. Stinson +4 more
semanticscholar +3 more sources
Application of Modified Flavone Closure for the Preparation of Racemic L86-8275.
ChemInform, 2010AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Tabaka, K. Murthi, K. Pal, C. Teleha
semanticscholar +2 more sources
2023
This product includes information on the manufacturer, engine, applications, testing location, certified maximum horsepower, certified maximum torque along with the certified curves of horsepower and torque over a wide range of engine RPM speeds.
openaire +1 more source
This product includes information on the manufacturer, engine, applications, testing location, certified maximum horsepower, certified maximum torque along with the certified curves of horsepower and torque over a wide range of engine RPM speeds.
openaire +1 more source
2023
This product includes information on the manufacturer, engine, application, testing location, certified maximum horsepower, certified maximum torque along with the certified curves of horsepower and torque over a wide range of engine RPM speeds.
openaire +1 more source
This product includes information on the manufacturer, engine, application, testing location, certified maximum horsepower, certified maximum torque along with the certified curves of horsepower and torque over a wide range of engine RPM speeds.
openaire +1 more source
Digitization and the Market for Physical Works: Evidence from the Google Books Project
American Economic Journal: Economic Policy, 2023The free digital distribution of creative works could cannibalize demand for physical versions, but it could also boost physical sales by enabling consumers to discover the original work.
Abhishek Nagaraj, Imke Reimers
semanticscholar +1 more source