Results 171 to 180 of about 1,620 (199)

Potent Inhibition of Cdc2 Kinase Activity by the Flavonoid L86-8275

Biochemical and Biophysical Research Communications, 1994
L86-8275 [(-) cis-5,7-dihydroxy-2-(2-chlorophenyl)-8[4-(3-hydroxy-1- methyl)-piperidinyl]-4H-benzopyran-4-one] directly inhibits immunoprecipitated Cdc2 kinase activity from G2/M synchronized MDA-MB-468 breast carcinoma cells and is at least 250-fold more potent than either quercetin or genistein.
M D, Losiewicz, B A, Carlson, G, Kaur, E A, Sausville, P J, Worland   +4 more
exaly   +9 more sources

Application of Modified Flavone Closure for the Preparation of Racemic L86-8275

Organic Process Research & Development, 1999
The laboratory preparation of racemic L86-8275 (1a) and the salt (1b) is described in 7% overall yield. Our method eliminated a number of chromatography steps from the patent procedure and improved the flavone-forming reaction by employing a stepwise mechanism. Solvent-free conditions for the demethylation step are also described.
A. Christine Tabaka, Krishna K. Murthi, Kollol Pal, Christopher A. Teleha   +3 more
openaire   +3 more sources

Long-term outcome of L86 and L97 protocols for adult acute lymphoblastic leukemia

Leukemia & Lymphoma, 2008
We analysed the long-term outcome of the L86 protocol using L-asparaginase (L-asp), vincristine (VCR) and prednisolone (PSL), collectively known as LVP or L97 protocol using LVP along with pirarubicin hydrochloride (THP-ADR) for 97 patients with acute lymphoblastic leukemia (ALL) diagnosed between 1986 and 2002.
Hideyuki, Koharazawa, Heiwa, Kanamori, Rika, Sakai, Chizuko, Hashimoto, Sachiya, Takemura, Michiko, Hattori, Jun, Taguchi, Katsumichi, Fujimaki, Naoto, Tomita, Hiroyuki, Fujita, Shin, Fujisawa, Hiroshi, Harano, Koji, Ogawa, Shigeki, Motomura, Atsuo, Maruta, Yoshiaki, Ishigatsubo   +15 more
openaire   +4 more sources

Determination of flavopiridol (L86 8275; NSC 649890) in human plasma by reversed-phase liquid chromatography with electrochemical detection

Cancer Chemotherapy and Pharmacology, 1998
Flavopiridol is a flavone which inhibits several cyclin-dependent kinases, and exhibits potent growth-inhibitory activity against a number of human tumor cell lines both in vitro, and when grown as xenografts in mice. It is currently being evaluated in a phase I clinical trial at the National Cancer Institute.
S F, Stinson, K, Hill, T J, Siford, L R, Phillips, T W, Daw   +4 more
openaire   +4 more sources

The Lawn 1984–7 (lh84, la85, l86)

2006
openaire   +3 more sources

Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy

International Journal of Oncology, 1996
Flavopiridol is a new synthetic flavone, structurally related to a natural alkaloid, originally purified from Dysoxylum binectariferum, a plant indigenous to India and used in Indian folk medicine. Flavopiridol was detected by a tandem screening system consisting in inhibition of the EGF-receptor Tyrosine phosphokinase and cytotoxicity. As a cytostatic
H, Sedlacek, J, Czech, R, Naik, G, Kaur, P, Worland, M, Losiewicz, B, Parker, B, Carlson, A, Smith, A, Senderowicz, E, Sausville   +10 more
openaire   +2 more sources

ChemInform Abstract: Application of Modified Flavone Closure for the Preparation of Racemic L86‐8275.

ChemInform, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Christine Tabaka, Krishna K. Murthi, Kollol Pal, Christopher A. Teleha   +3 more
openaire   +1 more source

J1349 Certified Power Engine Data for GM L86 Small Block V8 as used in 2014 GM Pickups and 2015 SUV w/ L86 engine RPO 93 Octane PON - Level 2

2023
This product includes information on the manufacturer, engine, applications, testing location, certified maximum horsepower, certified maximum torque along with the certified curves of horsepower and torque over a wide range of engine RPM speeds.
openaire   +1 more source

J1349 Certified Power Engine Data for GM L86 Small Block V8 as used in 2014 GM Pickups and 2015 SUV w/ L86 engine RPO 93 Octane PON - Level 1

2023
This product includes information on the manufacturer, engine, application, testing location, certified maximum horsepower, certified maximum torque along with the certified curves of horsepower and torque over a wide range of engine RPM speeds.
openaire   +1 more source

J1349 Certified Power Engine Data for GM L86/L87 as used in 2019 T1xx - 93 Octane - Level 2

2023
This product includes information on the manufacturer, engine, applications, testing location, certified maximum horsepower, certified maximum torque along with the certified curves of horsepower and torque over a wide range of engine RPM speeds.
openaire   +1 more source