Results 111 to 120 of about 11,237,232 (250)
Human IDO2 exhibits unique binding affinities distinct to those of human IDO1
The FEBS Journal, EarlyView.Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi +8 more
wiley +1 more source
La Celestina y los poetas de la segunda mitad del siglo XX
Estudios Humanísticos. Filología, 2000 La Celestina y los poetas de la segunda mitad del siglo ...
José María Balcells
doaj +1 more source
[Don Quixote de la Mancha and the description of biphasic sleep in Spanish literature]. [PDF]
Rev Neurol, 2023 Balcarce-Bautista PE.
europepmc +1 more source
Histopathology, EarlyView.A user‐centred evaluation of four widely used WSI scanners revealed marked image quality differences but minimal impact on diagnostic sufficiency. Aim Whole slide imaging (WSI) scanners are fundamental to digital pathology, providing high‐resolution digitized histology slides.
Jonas Bäcker +14 more
wiley +1 more source
The Relations Among Prosocial Behavior, Life Satisfaction, and Hedonic Balance Among Young Adults
Journal of Personality, EarlyView.ABSTRACT Objective This study examined the intra‐individual associations between prosocial behavior and two dimensions of subjective well‐being—life satisfaction and hedonic balance—in the daily lives of young adults. Method Two samples of Italian and Spanish participants aged 18–35 completed self‐report measures at different intervals: a daily sample ...
Fulvio Gregori +13 more
wiley +1 more source
Public Administration, EarlyView.ABSTRACT New research argues that robust governance based on flexible adaptation and proactive innovation is needed in order to uphold core public functions, purposes, and values in times of societal turbulence. However, we have limited knowledge of the conditions for enhancing robust governance.
Jacob Torfing +9 more
wiley +1 more source
Dietary patterns, social determinants, and emotions during COVID-19 confinement in Panama: An online survey. [PDF]
Health Sci Rep, 2023 Rios M +5 more
europepmc +1 more source
Experimental Physiology, EarlyView.Abstract Obesity is associated with adverse changes in brain structure and function, in part, through crosstalk between adipose tissue (AT) and the brain. AT releases small extracellular vesicles (sEV) that can cross the blood–brain barrier (BBB) and modulate multiple pathophysiological pathways, including BBB function; however, this has never been ...
Shalini Mishra +6 more
wiley +1 more source
Challenges in the future of cancer screening
International Journal of Cancer, Volume 158, Issue 8, Page 2013-2022, 15 April 2026.Abstract The purpose of cancer screening is to reduce mortality, and ideally incidence, from the cancer screened for. Until recently, cancer screening has been offered to all persons in pre‐defined sex‐ and age‐groups. The exception is lung screening which is targeted to high‐risk individuals.
Elsebeth Lynge +29 more
wiley +1 more source