Results 41 to 50 of about 34,367,900 (254)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Regime térmico e hídrico do solo para área de floresta tropical em anos de El Niño e La Niña, Caxiuanã-PA: estudo de caso Thermal and hydrologic regime to soil at tropical forest area inyear of El Niño and La Niña, Caxiuanã-PA: a case study

Revista Brasileira de Meteorologia, 2011
Os regimes térmicos e hídricos do solo se comportam de maneiras diferentes em anos de ocorrência dos fenômenos El Niño, La niña e ano de não ocorrência de nenhum dos dois fenômenos. Para estudar estes comportamentos utilizou-se dados de totais horários e
Sergio Rodrigo Quadros dos Santos, Rommel Benicio Costa da Silva, Priscilla Nascimento Barreto, Hildo Giuseppe G. C Nunes, Ronaldo da Silva Rodrigues, Thamiris Luisa de Oliveira Bradão Campos   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Influência da La Niña na estação chuvosa da região sudeste do Brasil Influence of La Niña in the rainy season of the southeast region of Brazil

Revista Brasileira de Meteorologia, 2007
Dados diários de 203 estações pluviométricas, localizadas na região Sudeste do Brasil (SEB), foram utilizados com o propósito de analisar estatisticamente a influência do fenômeno La Niña (LN), no comportamento trimestral da precipitação durante a ...
Rosandro Boligon Minuzzi, Gilberto Chohaku Sediyama, José Maria Nogueira da Costa, Rubens Leite Vianello   +3 more
doaj   +1 more source

Geological and Archaeological Evidence of El Niño Events along the Coast of El Oro Province Ecuador: Excavations at La Emerenciana a Late Valdivia (ca. 2200 1450 B.C.) Ceremonial Center

Journal of Bioremediation & Biodegradation, 2015
El Niño es un calentamiento de las temperaturas superficiales del mar en el Océano Pacífico oriental. Tales perturbaciones climáticas y oceanográficas tienen impactos dramáticos sobre el medio ambiente y la adaptación humana. La evidencia multidisciplinaria de las excavaciones a gran escala en el centro ceremonial tardío de Valdivia de La Emerenciana ...
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Artículo Calidad del servicio y satisfacción del usuario del Programa de crecimiento y desarrollo del niño en un Centro de Salud Estatal de la Provincia de Trujillo.

EX CATHEDRA EN NEGOCIOS, 2019
El propósito de la presente investigación ha sido el de determinar si existe relación entre la calidad del servicio proporcionado por el cuidado de enfermería y la satisfacción de las madres usuarias del Programa de crecimiento y desarrollo del niño (CRED) en un Centro de Salud del Estado.
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Día Internacional de la Mujer y la Niña en la Ciencia: III Jornada organizada por el ISCIII [PDF]

, 2020
El martes 11 de febrero se celebra, un año más, el Día Internacional de la Niña y la Mujer en la Ciencia, que trata de impulsar la visibilidad y el reconocimiento de las mujeres en el ámbito científico, y de reforzar el interés de las jóvenes por la ...
Instituto de Salud Carlos III. Biblioteca Nacional de Ciencias de la Salud
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source