Results 41 to 50 of about 254,026 (305)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Pengaruh El Nino Southern Oscillation (Enso) Terhadap Curah Hujan Musiman Dan Tahunan Di Indonesia [PDF]
, 2013 Variabilitas utama iklim musiman dan tahunan di Indonesia dipengaruhi ENSO. ENSO merupakan sebuah interaksi laut atmosfer yang berpusat di wilayah ekuatorial Samudra Pasifik yang menyebabkan anomali iklim global, termasuk di Indonesia.
Nurjani, E. (Emilya) +1 more
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Geophysical Research LettersAccurately predicting the El Niño–Southern Oscillation (ENSO) remains a key challenge in climate science. An evaluation of the International Research Institute for Climate and Society (IRI) real‐time ENSO forecast system reveals an asymmetry in ...
Wenchang Ge +4 more
doaj +1 more source
March 2008 La Nina Update [PDF]
, 2008 An area of warm sea surface temperature has formed off the Peru coast. Watch this to possibly “kill” La Nina. By March 3 the water north of Australia was cooling and west of Peru was warming.Two signs of a La Nina about to fade (and with it the risk of ...
Taylor, S. Elwynn
core +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
, 2012 The drought of 2012 in the Midwest was a continuation of a weather anomaly that began in 2010. The historical indicator of El Nino and La Nina is the Southern Oscillation Index (SOI). The index is based on the 90-day standardized deviation of atmospheric
Taylor, S. Elwynn
core +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source