Results 71 to 80 of about 127,832,786 (299)

Integrating biological vasculature into a multi-organ-chip microsystem

, 2022
S.3588-3598A chip-based system mimicking the transport function of the human cardiovascular system has been established at minute but standardized microsystem scale.
Lindner, G., Sonntag, F., Menzel, U., Marx, U., Groth, B., Horland, R., Lauster, R., Hoffmann, S., Walles, Heike, Lorenz, A., Schimek, K., Busek, M., Brincker, S.   +12 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Siphon-Induced Droplet Break-Off for Enhanced Mixing on a Centrifugal Platform

Inventions, 2019
We present a powerful and compact batch-mode mixing and dilution technique for centrifugal microfluidic platforms. Siphon structures are designed to discretize continuous flows into a sequence of droplets of volumes as low as 100 nL.
Robert Burger, David J Kinahan, Hélène Cayron, Nuno Reis, João Fonseca, Jens Ducrée   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Automated electrochemical oxygen sensing using a 3D-printed microfluidic lab-on-a-chip system [PDF]

Dissolved oxygen is crucial for metabolism, growth, and other complex physiological and pathological processes; however, standard physiological models (such as organ-on-chip systems) often use ambient oxygen levels, which do not reflect the lower levels ...
Kaufman, Daniel, Shibli, Ahed, Bahnemann, Janina, Heuer, Christopher, Ben-Yoav, Hadar, Snezhko, Alexander, Livshits, Gideon I., Livshits, Gideon I, Winkler, Steffen   +8 more
core   +1 more source

The tooth on-a-chip: a microphysiologic model system mimicking the biologic interface of the tooth with biomaterials

, 2020
The tooth has a unique configuration with respect to biomaterials that are used for its treatment. Cells inside of the dental pulp interface indirectly with biomaterials via a calcified permeable membrane, formed by the dentin matrix and several ...
Bertassoni, Luiz E., Puppin Rontani, Regina Maria, Sereda, Grigoriy, Franca, Cristiane Miranda, Rodrigues, Nara Sousa, Tahayeri, Anthony, Ferdosian, Shirin, Ferracane, Jack L.   +7 more
core   +1 more source

Advances in analytical microfluidic workflows for differential cancer diagnosis

Nano Select, 2023
Early detection and functional analysis of circulating tumor cells (CTCs) in liquid biopsy rather than counting them offer great promise as physicians can improve differential diagnosis for second‐ or third‐line treatment beyond today's genotype ...
Morteza Hasanzadeh Kafshgari, Oliver Hayden   +1 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles

, 2015
Magnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells.
Souza, Joao C. P. de, Cabrera, Flavio C., Crespilho, Frank N., Job, Aldo E. [UNESP], Cabrera, Flavio C. [UNESP], Melo, Antonio F. A. A., Job, Aldo E.   +6 more
core   +1 more source

Impedance-based real-time position sensor for lab-on-a-chip devices [PDF]

, 2018
This paper presents the theoretical and experimental development of an integrated position sensor for lab-on-a-chip devices. The interest for single cell analysis is growing.
Gauthier, M., Cottet, J., Van Lintel, H., Renaud, P., B. Brazey, P. Renaud, H. Van Lintel, M. Gauthier, Brazey, B., Bolopion, A., A. Bolopion, Cottet, Jonathan, Brazey, Benoît, J. Cottet   +13 more
core   +1 more source