Results 61 to 70 of about 52,192,158 (333)

Machine-Learning-Assisted Analysis of Colorimetric Assays on Paper Analytical Devices

open access: yesACS Omega, 2021
Paper-based analytical devices (PADs) employing colorimetric detection and smartphone images have gained wider acceptance in a variety of measurement applications.
Bidur Khanal   +3 more
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Research Update on the Impact of Lactic Acid Bacteria on the Substance Metabolism, Flavor, and Quality Characteristics of Fermented Meat Products

open access: yesFoods, 2022
This paper reviews the effects of domestic and foreign influences on the substance metabolism pathways and the flavor and flora of LAB in fermented meat products to provide a new theoretical basis for developing new products for the industrial ...
Yi Wang   +6 more
doaj   +1 more source

Lab on a chip for continuous-flow magnetic cell separation [PDF]

open access: yes, 2015
Separation of cells is a key application area of lab-on-a-chip (LOC) devices. Among the various methods, magnetic separation of cells utilizing microfluidic devices offers the merits of biocompatibility, efficiency, and simplicity.
Nguyen, Nam-Trung   +6 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Reaserch Progress of Lactic Acid Baceria Synbiotics

open access: yesShipin gongye ke-ji, 2022
Synbiotics are microbial preparations composed of probiotics and prebiotics, which can play the role of probiotics and prebiotics at the same time. Synbiotics play a probiotic function, and the intestine is the target location for the intestine to play a
Jiaju XU, Lina LIU, Renpeng DU, Dan ZHAO
doaj   +1 more source

newcastle-living-lab/living-lab: Version 1.17.0

open access: yes, 2019
v1.17.0 <ul> <li>Added Layer Export/Import functionality.</li> <li>Started adding support for Audio files to Library/Design.</li> </ul> Export Layers <p>Layers and their child objects can be exported from the ...
Newcastle Living Lab, Craig A Rodway
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Lab-Sophistication: Does Repeated Participation in Laboratory Experiments Affect Pro-Social Behaviour?

open access: yesGames, 2021
Experimental social scientists working at research-intensive institutions deal inevitably with subjects who have most likely participated in previous experiments.
Tiziana Medda   +2 more
doaj   +1 more source

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