Results 71 to 80 of about 52,192,158 (333)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

rochefort-lab/fissa: Version 0.6.1

, 2019
<p>Release date: 2019-03-11. Full commit changelog <a href="https://github.com/rochefort-lab/fissa/compare/0.6.0...0.6.1">on github</a>.</p> Fixed <ul> <li>Allow <code>deltaf.findBaselineF0</code> to run ...
nathalierochefort, Sander Keemink, Scott Lowe, Rochefort Lab, Janelle Pakan   +4 more
core   +1 more source

cooperative-computing-lab/taskvine-paper: v1.0.0

, 2023
TaskVine is a task scheduler for building large scale data intensive dynamic workflows that run on HPC clusters, GPU clusters, and commercial clouds. It provides an API to construct applications in C and Python.
Thanh Son Phung, Barry Sly-Delgado, Andrew Hennessee, Benjamin Tovar, Douglas Thain, Colin Thomas, David Simonetti   +6 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Yli stereotypioista - keinoja sukupuolittuneiden alavalintojen purkamiseen [PDF]

, 2022
Suomessa on mahdollisuuksien tasa-arvo kouluttautua, mutta silti monet alat pysyvät mies- tai naisvaltaisina ja sukupuolistereotyyppiset alavalinnat toistuvat. Tämä julkaisu keskittyy käytännön keinoihin, joilla alavalintojen sukupuolittumista voi purkaa.
Elme, Elina, Anttila, Maisa
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Towards the Mass Production of Molecularly Imprinted Polymers via Cost-Effective Photopolymerization Synthesis and Colorimetric Detection via Smartphone

Chemosensors
The need for rapid, on-site contaminant detection is becoming increasingly vital for tackling environmental and public health challenges. This study introduces an efficient method for detecting sulfamethoxazole (SMX), a widely used antibiotic with ...
Kawtar Saidi, Dounia Elfadil, Aziz Amine
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Status of chemistry lab safety in Nepal.

PLoS ONE, 2017
Chemistry labs can become a dangerous environment for students as the lab exercises involve hazardous chemicals, glassware, and equipment. Approximately one hundred thousand students take chemistry laboratory classes annually in Nepal.
Krishna Prasad Kandel, Bhanu Bhakta Neupane, Basant Giri   +2 more
doaj   +1 more source

cooperative-computing-lab/taskvine-paper: v1.1.1

, 2023
TaskVine is a task scheduler for building large scale data intensive dynamic workflows that run on HPC clusters, GPU clusters, and commercial clouds. It provides an API to construct applications in C and Python.
Thanh Son Phung, Barry Sly-Delgado, Andrew Hennessee, Benjamin Tovar, Douglas Thain, Colin Thomas, David Simonetti   +6 more
core   +1 more source