Results 81 to 90 of about 501,707 (258)
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Fab Lab Research Papers. From Experiment To Expression
, 2018 Starting with a quick and dirty trial at Fab8 in Wellington, New Zeeland, the Fab Lab community has produced a considerable body of research over the past seven years. Together with colleagues Betty Barrett, Tomas Diez and Cindy Kohtala I’ve been carefully developing this endeavour to collect and present research that has been done at FabLabs, with ...
openaire +2 more sources
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Applying a Living Lab methodology to support innovation in education at a university in South Africa
The Journal for Transdisciplinary Research in Southern Africa, 2015 The Living Lab paradigm creates open and inter-disciplinary environments where participants can interrogate challenges and co-create solutions. A successful Living Lab context incorporates a clear focus/vision, strong leadership, self-sustainability, a ...
Ronel Callaghan, Marlien Herselman
doaj +1 more source
Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source
DESIGN AND CONSTRUCTION OF A LAB-ON-A-PAPER FOR LOW-COST AND DISPOSABLE POINT-OF CARE DIAGNOSTICS
Jurnal Sains Dasar, 2017 This paper presents a low-cost and disposable paper based microfluidic analysis system for point-of-care diagnostics. Detection is achieved by using a colorimetric or visual indicator.
Afnidar Afnidar, Bambang Kuswandi
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han +8 more
wiley +1 more source
Global Social Innovation Lab: Theoretical Perspectives
Canadian Journal for New Scholars in Education, 2022 This paper examines the use of education theories in designing and implementing innovative digital education strategies at a global scale. The text overviews issues associated with research and theory-based teaching in education practice.
Tatjana Brkic, Tejal Shah
doaj
Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane +19 more
wiley +1 more source