Results 161 to 170 of about 3,499,843 (203)
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Analytical Biochemistry, 2013
A surface plasmon resonance (SPR) array imaging method is outlined for label-free cell profiling. Red blood cells (RBCs) were injected into a flow chamber on top of a spotted sensor surface. Spots contained antibodies to various RBC membrane antigens. A typical sensorgram showed an initial response corresponding to cell sedimentation (S) followed by a ...
Schasfoort, Richard B. M. +6 more
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A surface plasmon resonance (SPR) array imaging method is outlined for label-free cell profiling. Red blood cells (RBCs) were injected into a flow chamber on top of a spotted sensor surface. Spots contained antibodies to various RBC membrane antigens. A typical sensorgram showed an initial response corresponding to cell sedimentation (S) followed by a ...
Schasfoort, Richard B. M. +6 more
openaire +3 more sources
Recent advances in label-free detection in vitro and label-free imaging in vivo
Coordination Chemistry ReviewsChun-Yang Zhang
exaly +2 more sources
Label-Free Proteomics of Serum
2008In this chapter we describe a method to analyze human serum with the goal of discovering disease-related changes in the serum proteome. The methodology is based on the removal of the six most abundant serum proteins by immunoaffinity chromatography. This step is followed by trypsin digestion and reversed-phase high-performance liquid chromatography ...
Govorukhina, N.I +2 more
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2009
Label-free biosensors are devices that use biological or chemical receptors to detect analytes (molecules) in a sample. They give detailed information on the selectivity, affinity, and, in many cases, also the binding kinetics and thermodynamics of an interaction. Although they can be powerful tools in the hands of a skilled user, there is often a lack
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Label-free biosensors are devices that use biological or chemical receptors to detect analytes (molecules) in a sample. They give detailed information on the selectivity, affinity, and, in many cases, also the binding kinetics and thermodynamics of an interaction. Although they can be powerful tools in the hands of a skilled user, there is often a lack
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2021
In this chapter, we focus on label-free biosensors. First, we look at sensors with optical detection. In this context, the Mach–Zehnder interferometer and the surface plasmon resonance offer the possibility to limit the optical examination to shallow surface layers. The second group are the gravimetric biosensors.
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In this chapter, we focus on label-free biosensors. First, we look at sensors with optical detection. In this context, the Mach–Zehnder interferometer and the surface plasmon resonance offer the possibility to limit the optical examination to shallow surface layers. The second group are the gravimetric biosensors.
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Label-Free Sensing on Microarrays
2016Microarrays of biological molecules such as DNAs, proteins, carbohydrates, and small molecules provide a high-throughput platform for screening tens of thousands of biomolecular interactions simultaneously, facilitating the functional characterization of these biomolecules in areas of genomics, proteomics, glycomics, and cytomics.
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Nature Methods, 2009
New methods to coax signals from unlabeled biological molecules may finally fulfill the promise of practical label-free microscopy with molecular specificity.
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New methods to coax signals from unlabeled biological molecules may finally fulfill the promise of practical label-free microscopy with molecular specificity.
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Label-free biodetection using a smartphone
Lab on a Chip, 2013Utilizing its integrated camera as a spectrometer, we demonstrate the use of a smartphone as the detection instrument for a label-free photonic crystal biosensor. A custom-designed cradle holds the smartphone in fixed alignment with optical components, allowing for accurate and repeatable measurements of shifts in the resonant wavelength of the sensor.
Dustin, Gallegos +7 more
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Label-free capacitance DNA sensing
2013 Seventh International Conference on Sensing Technology (ICST), 2013This paper presents the use of direct capacitance measurements for label free hybridization detection of ssDNA immobilized directly on a gold interdigitated array of microelectrodes (IDAM). Thiol modified 18 bases long Poly-dT ssDNA molecules were immobilized on the Au IDAM surface without the use of any isolative self assembled monolayer (SAM ...
Phillip M. Rivera Ortiz +3 more
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Virtual Staining of Label-free Tissue
Frontiers in Optics + Laser Science 2024 (FiO, LS)We will cover deep learning-based virtual staining techniques that can generate different types of histological stains from label-free microscopic images of unstained samples by using, e.g., autofluorescence microscopy, quantitative phase imaging and reflectance confocal microscopy.
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