Results 51 to 60 of about 2,939,424 (357)

Relabelling Algorithms for Large Dataset Mixture Models [PDF]

, 2014
Mixture models are flexible tools in density estimation and classification problems. Bayesian estimation of such models typically relies on sampling from the posterior distribution using Markov chain Monte Carlo.
Fan, Yanan, Zhu, Wanchuang
core  

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Optimizing segment routing using evolutionary computation [PDF]

, 2017
Segment Routing (SR) combines the simplicity of Link-State routing protocols with the flexibility of Multiprotocol Label Switching (MPLS). By decomposing forwarding paths into segments, identified by labels, SR improves Traffic Engineering (TE) and ...
McKeown, Mohiuddin, Moreno, Sridharan, Srivastava, Xu, Xu   +6 more
core   +1 more source

Switching to riociguat: a potential treatment strategy for the management of CTEPH and PAH

Pulmonary Circulation, 2020
Currently, five classes of drug are approved for the treatment of pulmonary arterial hypertension (PAH): phosphodiesterase 5 inhibitors (PDE5i); endothelin receptor antagonists; prostacyclin analogs; the IP receptor agonist selexipag; and the soluble ...
Raymond L. Benza, Paul A. Corris, Hossein-Ardeschir Ghofrani, Manreet Kanwar, Vallerie V. McLaughlin, Amresh Raina, Gérald Simonneau   +6 more
doaj   +1 more source

Benefits of Switching Mycophenolic Acid to Sirolimus on Serological Response after a SARS-CoV-2 Booster Dose among Kidney Transplant Recipients: A Pilot Study

Vaccines, 2022
Kidney transplant recipients (KTRs) have a suboptimal immune response to COVID-19 vaccination due to the effects of immunosuppression, mostly mycophenolic acid (MPA).
Athiphat Banjongjit, Supitchaya Phirom, Jeerath Phannajit, Watsamon Jantarabenjakul, Leilani Paitoonpong, Wonngarm Kittanamongkolchai, Salin Wattanatorn, Wisit Prasithsirikul, Somchai Eiam-Ong, Yingyos Avihingsanon, Pokrath Hansasuta, Jakapat Vanichanan, Natavudh Townamchai   +12 more
doaj   +1 more source

Efficacy and Safety of Switching from Innovator Rituximab to Biosimilar CT-P10 Compared with Continued Treatment with CT-P10: Results of a 56-Week Open-Label Study in Patients with Rheumatoid Arthritis

BioDrugs, 2017
CT-P10 is a biosimilar candidate of innovator rituximab (RTX) that demonstrated a comparable clinical profile to RTX in a phase I randomized controlled trial (RCT) in rheumatoid arthritis (RA) (ClinicalTrials.gov identifier: NCT01534884). This open-label
W. Park, C. Suh, S. Shim, F. F. C. Molina, S. Jeka, F. Medina-Rodriguez, P. Hrycaj, P. Wiland, Eun Young Lee, P. Shesternya, V. Kovalenko, L. Myasoutova, M. Stanislav, S. Radominski, M. Lim, J. Choe, Sang Joon Lee, S. Y. Lee, Sung Hwan Kim, D. Yoo   +19 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Tunable 4-channel ultra-dense WDM demultiplexer with III-V photodiodes integrated in silicon-on-insulator [PDF]

, 2012
A tunable 4-channel ultra-dense WDM demultiplexer with 0.25nm channel spacing is demonstrated with III-V photodiodes integrated on Silicon-on-Insulator using rib waveguides.
De Heyn, Peter, Keyvaninia, Shahram, Trita, Andrea, Van Thourhout, Dries, Verstuyft, Steven   +4 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source