Results 101 to 110 of about 1,572,118 (296)
Molecular architecture of human polycomb repressive complex 2
eLife, 2012 Polycomb Repressive Complex 2 (PRC2) is essential for gene silencing, establishing transcriptional repression of specific genes by tri-methylating Lysine 27 of histone H3, a process mediated by cofactors such as AEBP2.
Claudio Ciferri +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Editorial: In-vivo targeting of nuclear DNA with radioactive copper-64 ions
Frontiers in Medicine, 2023 Bianca Gutfilen, Adriano Duatti
doaj +1 more source
, 2012 In this paper we introduce a generalization of the well known concept of a graceful labeling. Given a graph G with e=dm edges, we call d-graceful labeling of G an injective function from V(G) to the set {0,1,2,..., d(m+1)-1} such that {|f(x)-f(y)| | [x,y]
Pasotti, A.
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Detection of Hacker Intention Using Deep Packet Inspection
Journal of Cybersecurity and PrivacyIdeally, in a real cyberattack, the early detection of probable hacker intent can lead to improved mitigation or prevention of exploitation. With the knowledge of basic principles of communication protocols, the reconnaissance/scanning phase intentions ...
Justin Foreman +5 more
doaj +1 more source
Market differentiation potential of country-of-origin, quality and traceability labeling [PDF]
, 2009 Product labeling has gained considerable attention recently, as a means to both provide product-specific information and reduce quality uncertainty faced by consumers, as well as from a regulatory point of view.
Roosen, Jutta, Verbeke, Wim
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