Molecular architecture of human polycomb repressive complex 2
eLife, 2012 Polycomb Repressive Complex 2 (PRC2) is essential for gene silencing, establishing transcriptional repression of specific genes by tri-methylating Lysine 27 of histone H3, a process mediated by cofactors such as AEBP2.
Claudio Ciferri +5 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 1997 This document describes a scheme for labeling a program dependence graph (PDG) or control flow graph (CFG) in order to codify the hierarchical control dependence structure of a procedure. The first section describes the scheme and its features. Section 2
Chris J. Newburn, Node Labeling
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Beef Labeling After BSE: Do Consumers Care about BSE Testing and GMO Labeling? Evidence from Canada and the US [PDF]
Following the May 2003 Canadian BSE case, food safety issues have become even more prominent to policymakers and consumers. In both Canada and the US, governments and industry have responded with a variety of quality assurance, traceability and labeling ...
Yang, Jun, Steiner, Bodo E.
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
COUNTRY-OF-ORIGIN LABELING OF BEEF PRODUCTS: U.S. CONSUMERS' PERCEPTIONS [PDF]
In 2002, Chicago and Denver consumers were surveyed and participated in an experimental auction to elicit willingness to pay for country-of-origin labeling (COOL) of beef. Survey results indicate the majority of consumers (73%) were willing to pay an 11%
Umberger, Wendy J. +3 more
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Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
A note on the primal-dual method for the semi-metric labeling problem [PDF]
, 2007 Recently, Komodakis et al. [6] developed the FastPD algorithm for the semi-metric labeling problem, which extends the expansion move algorithm of Boykov et al. [2].
Kolmogorov, V.
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Editorial: In-vivo targeting of nuclear DNA with radioactive copper-64 ions
Frontiers in Medicine, 2023 Bianca Gutfilen, Adriano Duatti
doaj +1 more source