Results 91 to 100 of about 1,572,118 (296)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Weak Set-Labeling Number of Certain IASL-Graphs
, 2015 Let $\mathbb{N}_0$ be the set of all non-negative integers, let $X\subset \mathbb{N}_0$ and $\mathcal{P}(X)$ be the the power set of $X$. An integer additive set-labeling (IASL) of a graph $G$ is an injective function $f:V(G)\to \mathcal{P}(\mathbb{N}_0)$
Chithra, K. P. +2 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
PRODUCTOS AGROALIMENTARIOS DE CALIDAD COMO MECANISMO DE PROTECCIÓN DE PRODUCTORES Y DE CONSUMIDORES. [PDF]
Revista Internacional de Doctrina y Jurisprudencia, 2014 For regulation of the hallmarks of quality wine, the European Union has approved a list of rules on the protection, production, labeling and control that protect those names. This article makes an analysis on the subject.
Ángel Sánchez Hernández
doaj
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The economics of GM food labels: An evaluation of mandatory labeling proposals in India [PDF]
"Labeling of genetically modified (GM) foods is a contentious issue and internationally, there is sharp division whether such labeling ought to be mandatory. This debate has reached India where the government has proposed mandatory labeling.
Bansal, Sangeeta, Ramaswami, Bharat
core
A simple and optimal ancestry labeling scheme for trees
, 2015 We present a $\lg n + 2 \lg \lg n+3$ ancestry labeling scheme for trees. The problem was first presented by Kannan et al. [STOC 88'] along with a simple $2 \lg n$ solution. Motivated by applications to XML files, the label size was improved incrementally
A Deutsch +6 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source