Results 91 to 100 of about 759,283 (267)
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Editorial: In-vivo targeting of nuclear DNA with radioactive copper-64 ions
Frontiers in Medicine, 2023 Bianca Gutfilen, Adriano Duatti
doaj +1 more source
BMJ, 2003 How useful is it to label a set of complaints as failed back surgery syndrome or post-discotomy syndrome? My view is that, far from improving a patient's condition, such a label may even play a part in its deterioration. Even the authors of articles who use these diagnostic terms admit that they are better avoided since they do not help to identify a ...
openaire +4 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Detection of Hacker Intention Using Deep Packet Inspection
Journal of Cybersecurity and PrivacyIdeally, in a real cyberattack, the early detection of probable hacker intent can lead to improved mitigation or prevention of exploitation. With the knowledge of basic principles of communication protocols, the reconnaissance/scanning phase intentions ...
Justin Foreman +5 more
doaj +1 more source
Journal of Public Health in Africa, 2016 Labeling information and quality of marketed Moringa oleifera products were assessed. Personnel in 60 pharmacies and 11 herbal shops were interviewed about the sources, dosages, indications and counseling information of Moringa oleifera products. Content
Tsitsi Grace Monera-Penduka +5 more
doaj +1 more source
Towards Label Imbalance in Multi-label Classification with Many Labels
CoRR, 2016 In multi-label classification, an instance may be associated with a set of labels simultaneously. Recently, the research on multi-label classification has largely shifted its focus to the other end of the spectrum where the number of labels is assumed to be extremely large.
Li Li, Houfeng Wang
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source