Results 31 to 40 of about 7,444 (161)

Initiation or continuation of oral labetalol versus extended‐release nifedipine in expectant management of preeclampsia with severe features

Pregnancy, Volume 2, Issue 5, September 2026.
Abstract Introduction Preeclampsia with severe features remains a major contributor to maternal and neonatal morbidity. In select patients <34 weeks, expectant management may safely prolong pregnancy and improve neonatal outcomes. Oral labetalol and extended‐release nifedipine are commonly used for blood pressure control in this setting; however ...
Ryan Farias, Christopher Ennen
wiley   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, Volume 104, Issue 6, Page e630-e647, September 2026.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

COMPARISON OF HYDRALAZINE AND LABETALOL IN THE MANAGEMENT OF HYPERTENSIVE DISORDERS OF PREGNANCY

Pakistan Armed Forces Medical Journal, 2022
Objective: To compare the efficacy of intravenous hydralazine and intravenous labetalol for acutely lowering blood pressure in pregnancy. Study Design: Randomized control trial (RCT).
Humaira Osman Jaffery, Kausar Tasleem Bangash   +1 more
doaj   +2 more sources

Neurodevelopmental Phenotypes and Brain Anomalies in Individuals With Heterozygous SEMA6A Variants

Clinical Genetics, Volume 110, Issue 3, Page 325-335, September 2026.
SEMA6A plays a role in cell migration and axon guidance in the developing central nervous system. Phenotypes seen in eleven individuals heterozygous for SEMA6A variants included developmental delay, intellectual disability, autism/autistic behaviors, behavioral abnormalities, attention disorders, hypotonia, and brain anomalies.
Evan Burchfiel, Xiaonan Zhao, Nichole M. Owen, Tia Gordon, Mahshid S. Azamian, Eric C. Kao, Fan Xia, Xi Luo, Jill A. Rosenfeld, Seema R. Lalani, Allison P. Ortega, Steven B. Bleyl, Florence Petit, Sulekha Rajagopolan, Bénédicte Demeer, Meredith K. Gillespie, Lijia Huang, Matthew Osmond, Kym M. Boycott, Kyra E. Stuurman, Marjon A. van Slegtenhorst, Haley Soller, Céline Jost, Aurore Garde, Hana Safraou, Laurence Faivre, Victor Faundes, Daryl A. Scott   +27 more
wiley   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2764-2776, August 2026.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Safety and efficacy of continuous intravenous labetalol for blood pressure control in neurosurgical patients

Journal of International Medical Research, 2023
Objectives Current evidence supporting the use of continuous intravenous labetalol for blood pressure (BP) control in neurosurgical patients is limited. This study aims to assess the efficacy and safety of labetalol in neurosurgical patients and identify
Raywat Noiphithak , Gahn Duangprasert , Sasikan Sukhor , Pichayaphong Durongkaweroj, Vich Yindeedej   +4 more
doaj   +1 more source

A comparative study of intravenous labetalol VS intravenous nitroglycerin in the treatment of hypertensive crises

Indian Heart Journal, 2022
Hypertensive crises is still a major public health problem, causing end organ damage like myocardial infarction, stroke, and renal failure. Labetalol and nitroglycerine are among the two most commonly used medicine to control the blood pressure, but ...
Mohammad Azharuddin Malik, Rehan Ahmad, Mujahid Beg, Rizwan Ahmad   +3 more
doaj   +1 more source

The effect of antihypertensive treatment on longitudinal changes in PLGF and sFlt‐1 in women with new onset hypertension in pregnancy

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 8, Page 1515-1522, August 2026.
In pregnant women with new‐onset hypertension starting antihypertensives, some achieve tight BP control within a week (Group 1‐blue line), while others respond slower (Group 2‐red line). Group 1 showed higher Log10PLGF levels, but Log10sFlt‐1 did not differ between groups. Over time, Log10PLGF declined in both groups, while Log10sFlt‐1 remained stable.
Edward Tyrell, Katherine G. Y. Lau, Martyna Bednorz, Kypros H. Nicolaides, Nikos A. Kametas   +4 more
wiley   +1 more source

Comparison of Labetalol, Nitroglycerine and High Dose Propofol for Induced Hypotension in Functional Endoscopic Sinus Surgery in Massive Nasal Polyposis: A Randomized Trial

Archives of Anesthesia and Critical Care, 2020
Background: The aim of this study was to assess the quality of the surgical field, amount of blood loss, and duration of surgery following induced hypotension with labetalol, nitroglycerin, and high dose propofol in patients undergoing FESS under general
Seyed Mohammad Mireskandari, Jalil Makarem, Babak Saedi, Afshin Jafarzadeh, Kasra Karvandian, Negar Eftekhar, Shahram Samadi, Hossein Majedi, Amin Amali, Roja Toosi, Batool Naghavi, Fardis Vosoughi   +11 more
doaj   +1 more source

Fluorinated Aminopiperidones as Non‐Glutarimide Thalidomide Analogs: Stereodivergent Synthesis and Validation

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Fluorinated aminopiperidones, designed as non‐glutarimide thalidomide analogs, were synthesized with full regio‐ and stereocontrol. The C*–CF3 used as carbonyl surrogate improved solubility and membrane interactions while abolishing cereblon binding.
Boštjan Adamlje, Tihomir Tomašič, Christian Steinebach, Sebastian Ebeling, Alexander Herrmann, Marcus D. Hartmann, Jessica L. Horner, Kinjal Bhadresha, Cindy H. Chau, William D. Figg, Izidor Sosič, Andrej Emanuel Cotman   +11 more
wiley   +1 more source