Results 11 to 20 of about 8,067 (167)
Hepatotoxicity Associated with Labetalol Use: A Case Report with Systematic Review and Disproportionality Analysis Using FAERS. [PDF]
J Clin PharmacolAbstract Labetalol is widely prescribed as a first‐line antihypertensive in pregnancy; however, rare but potentially severe idiosyncratic hepatotoxicity has been reported, with a disproportionately strong reporting signal for liver injury relative to other β‐blockers.
Hendriksen ED, Rieder M, Urbantke E.
europepmc +2 more sources
Treatment of post-coarctectomy hypertension with labetalol: a 9-year single-center experience
, 2022 Background: Although considering the pathophysiology of post-coarctectomy hypertension, beta-blockers should be effective, experience with labetalol for treatment is limited in the literature.
Siersma, C. +4 more
core +1 more source
Labetalol (Trandate, Glaxo Inc.; Normodyne, Schering Corp.)
, 1983 Labetalol is a competitive antagonist of α1-, β1-, and β2-adrenergic receptors. The hemodynamic effects of the drug include reduced blood pressure, heart rate, and peripheral resistance, with little change in resting cardiac output or stroke volume.
Barry L. Carter
core +1 more source
Labetalol-induced hepatotoxicity during pregnancy: a case report
, 2020 Background Drug-induced liver injury is a common cause of transaminitis, occurring in up to 5% of patients who are hospitalized for liver failure. In pregnancy, transaminitis is seen in conditions which may require expedited delivery.
Berkelhammer, Charles +4 more
core +1 more source
Inadvertent intrathecal injection of labetalol
, 2016 Labetalol is a combined α and β adrenergic receptor blocker. It is used to treat hypertension, especially in pregnant patients. We report a case of a female patient who was given labetalol intrathecally in place of bupivacaine due to a similar appearance
S Verma, V Sharma, P Sethi, P K Bhatia
core +1 more source
Influences of Labetalol on the Function of Mammalian Digestive System
, 1980 Influences of labetalol, an alpha and beta adrenoceptor blocking agent, on the function of mammalian digestive system were investigated. 1） Large amounts of labetalol （200 mg/kg, p.o., 10 mg/kg, i.v.） delayed gastrointestinal transit in mice.
大鹿, 英世 +3 more
core +1 more source
, 2020 Background-In pregnancy to control the severe hypertension situation, there is no record about the safety of intravenous labetalol and hydralazine. Labetalol and hydralazine both have their own disadvantage and advantages.
Muhammad Zulqarnain, Maimoona Shabbir, Muhammad Mubeen Yaseen
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf +6 more
wiley +1 more source
Effect of Labetalol on Salivation in Mice
, 1980 The effects of labetalol on salivation in mice were investigated and following results were obtained. 1） While pilocarpine-induced salivation was not affected by pretreatment with labetalol （1 mg/kg and 10 mg/kg, i.
大鹿, 英世 +2 more
core +1 more source
JCPP Advances, EarlyView.This systematic review investigated the association of prenatal exposure to antihypertensive medication with longer‐term poor neurodevelopmental outcomes by evaluating the findings from existing literature. We undertook a systematic review of previous studies looking specifically at neurodevelopmental outcomes in children.
Shrifah Alkhalaf +5 more
wiley +1 more source