TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo+11 more
wiley +1 more source
Evaluation of Allplex™ GI-Parasite Assay-A Multiplex Real Time PCR for the Diagnosis of Intestinal Protozoa: A Multicentric Italian Study. [PDF]
Oliva E+8 more
europepmc +1 more source
The States-as-Laboratories Metaphor in State Constitutional Law [PDF]
Gardner, James A.
core +2 more sources
Nitric oxide‐forming nitrite reductases in the anaerobic ammonium oxidizer Kuenenia stuttgartiensis
Anammox bacteria remove fixed nitrogen from their environment via anaerobic ammonium oxidation (anammox) with nitrite as electron acceptor and dinitrogen gas as product. The first anammox step is the conversion of nitrite to nitric oxide by nitrite reductase.
Femke J. Vermeir+4 more
wiley +1 more source
Strengthening governance and leadership of the national laboratory system in Liberia: achievements and challenges. [PDF]
Kohar TH+6 more
europepmc +1 more source
Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno+12 more
wiley +1 more source
Artificial intelligence-assisted HER2 interpretation for breast cancers in a multi-laboratory study. [PDF]
Yang L+13 more
europepmc +1 more source
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu+12 more
wiley +1 more source
Climate change and medical laboratory operations: Impacts, challenges, and adaptation strategies: A narrative review. [PDF]
Obeagu EI, Bolo B.
europepmc +1 more source